Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Integration of genomics, epigenomics, and transcriptomics in understanding Alzheimer's pathogenesis

With the advent of new omics technologies in recent years, there has been a deluge of complex, high-dimensional data on Alzheimer's disease (AD).

12 Jun 2024

New AARF-D award supports Temple researchers to explore synapse function in the aging brain

Late-life depression is a major risk factor for Alzheimer's disease, in particular because it accelerates progression from mild cognitive impairment to dementia.

12 Jun 2024

Long-read RNA sequencing reveals novel insights into alternative splicing and disease genetics

Tokyo Medical and Dental University (TMDU) researchers harness long-read RNA sequencing to decode genetic intricacies and disease links.

12 Jun 2024

Few UK Alzheimer's patients suitable for new disease-modifying drugs, study finds

Few people in the UK with early stage Alzheimer's disease are likely to be suitable for the latest drugs which aim to halt progress of the condition, yet many are nevertheless likely to be referred for these treatments, finds research published online in the Journal of Neurology Neurosurgery & Psychiatry.

11 Jun 2024

Patient perspectives highlight urgent need for research on smell and taste disorders

Researchers and patient advocates from the Monell Chemical Senses Center, Smell and Taste Association of North America (STANA), and Thomas Jefferson University came together during the COVID-19 pandemic to incorporate patient voices in efforts to prioritize research areas focused on improving care for people with smell and taste disorders.

10 Jun 2024

Can lifestyles changes reduce Alzheimer’s risk?

Intensive lifestyle changes significantly improve cognition and function in patients with mild cognitive impairment or early dementia due to Alzheimer’s disease over a 20-week period, showing promising results for non-pharmacological interventions.

10 Jun 2024

Johns Hopkins researchers discover how epilepsy drug modulates brain activity

By super cooling a molecule on the surface of brain cells down to about minus 180 degrees Celsius - nearly twice as cold as the coldest places in Antarctica - scientists at Johns Hopkins Medicine say they have determined how a widely-used epilepsy drug works to dampen the excitability of brain cells and help to control, although not cure, seizures.

10 Jun 2024

Transplanted gut microbes from aged mice trigger inflammation in young germ-free mice

When scientists transplanted the gut microbes of aged mice into young "germ-free" mice - raised to have no gut microbes of their own - the recipient mice experienced an increase in inflammation that parallels inflammatory processes associated with aging in humans.

10 Jun 2024

New brain connectivity model predicts dementia years before diagnosis

Whether the default-mode network (DMN) effective connectivity can predict future dementia diagnosis at the individual level.

10 Jun 2024

Surprising link between a diverse oral microbiome and better cognitive function in aging

Study found that higher oral microbiome diversity is linked to better cognitive function and fewer memory issues in older US adults, highlighting the "oral-brain axis."

9 Jun 2024

Changes in exploration behavior suggest early signs of cognitive decline in middle age

Spatial navigation – the ability to select and follow a route from one place to another – is a skill we use every day. Depending on practice, general cognitive ability, and childhood environment, some people are naturally better at this than others. But research has also shown that people’s skill in spatial navigation tends to decrease with increasing age.

8 Jun 2024

Developing pre-symptomatic diagnostic tools for Alzheimer's disease using long-read RNA sequencing

Researchers at the University of Kentucky Sanders-Brown Center on Aging are working to develop a pre-symptomatic disease diagnostic tool for Alzheimer's disease.

6 Jun 2024

Ohio State creates user-friendly repository to help study Alzheimer's disease

A searchable database is now ready to help study Alzheimer's disease.

6 Jun 2024

New method provides a more accurate way to predict dementia up to nine years before diagnosis

Researchers at Queen Mary University of London have developed a new method for predicting dementia with over 80% accuracy and up to nine years before a diagnosis.

6 Jun 2024

5-Cog paradigm: A breakthrough in dementia diagnosis and care

The underdiagnosis of dementia, especially among Black and Hispanic patients, is a long-standing challenge in medicine.

4 Jun 2024

Researchers discover age-related changes in the lipid metabolism of mice

Researchers at the RIKEN Center for Integrative Medical Sciences (IMS) have discovered numerous age-related changes in the lipid metabolism of mice, across both organs and sexes.

4 Jun 2024

Young bone marrow transplants show promise in reversing Alzheimer's symptoms in mice

Researchers found that young bone marrow transplants rejuvenate aging immune cells, reducing Alzheimer's symptoms in mice models, suggesting a potential therapeutic approach for the disease.

4 Jun 2024

Weakening credit scores and rising delinquency may be warning signs of undiagnosed memory disorders

In the years prior to an Alzheimer's disease or other memory disorder diagnosis, credit scores begin to weaken and payment delinquency begins to increase, concludes new research led by Georgetown University.

31 May 2024

Study reveals sex-specific cognitive effects of astrocytic receptors

Weill Cornell Medicine scientists have uncovered the first evidence that astrocyte receptors can trigger opposite effects on cognitive function in male and female preclinical models.

30 May 2024

Older adults with a criminal background found to have higher risk of developing dementia

Using national registry data, Carmen Solares Canal identified individuals over fifty and collected data on their criminal convictions and health.

30 May 2024

Alzheimer's Disease News and Research

Further Reading

Integration of genomics, epigenomics, and transcriptomics in understanding Alzheimer's pathogenesis

New AARF-D award supports Temple researchers to explore synapse function in the aging brain

Long-read RNA sequencing reveals novel insights into alternative splicing and disease genetics

Few UK Alzheimer's patients suitable for new disease-modifying drugs, study finds

Patient perspectives highlight urgent need for research on smell and taste disorders

Can lifestyles changes reduce Alzheimer’s risk?

Johns Hopkins researchers discover how epilepsy drug modulates brain activity

Transplanted gut microbes from aged mice trigger inflammation in young germ-free mice

New brain connectivity model predicts dementia years before diagnosis

Surprising link between a diverse oral microbiome and better cognitive function in aging

Changes in exploration behavior suggest early signs of cognitive decline in middle age

Developing pre-symptomatic diagnostic tools for Alzheimer's disease using long-read RNA sequencing

Ohio State creates user-friendly repository to help study Alzheimer's disease

New method provides a more accurate way to predict dementia up to nine years before diagnosis

5-Cog paradigm: A breakthrough in dementia diagnosis and care

Researchers discover age-related changes in the lipid metabolism of mice

Young bone marrow transplants show promise in reversing Alzheimer's symptoms in mice

Weakening credit scores and rising delinquency may be warning signs of undiagnosed memory disorders

Study reveals sex-specific cognitive effects of astrocytic receptors

Older adults with a criminal background found to have higher risk of developing dementia

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