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Reversing adipose tissue fibrosis through targeted microRNA therapies

A new review published in Genes & Diseases highlights the transformative role of microRNAs (miRNAs) in regulating and potentially reversing adipose tissue fibrosis, a condition closely linked to obesity, diabetes, and cardiovascular disease.

20 Apr 2025

Mitochondrial pyruvate carrier structure solved after fifty years

Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the 'powerhouses' of our cells, allows us to make the fuel we need from sugars, a process vital to all life on Earth.

18 Apr 2025

Evaluating hydronidone for the treatment of chronic hepatitis B-associated liver fibrosis

Liver fibrosis is a key process in the progression of chronic liver diseases. However, there are currently no drugs specifically designed to treat liver fibrosis.

18 Apr 2025

Study examines how COX-2 regulates ferroptosis in chronic liver injury

Ferroptosis plays an essential role in chronic liver diseases, and cyclooxygenase-2 (COX-2) affects liver fibrosis through multiple mechanisms. +

18 Apr 2025

Researchers use algorithm to pinpoint disease risk mutations in noncoding DNA

Researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania (Penn Medicine) have successfully employed an algorithm to identify potential mutations which increase disease risk in the noncoding regions our DNA, which make up the vast majority of the human genome.

17 Apr 2025

Nontraditional risk factors linked to stroke in adults under 50

Adults younger than 50 years of age had more than double the risk of having a stroke from migraine or other nontraditional stroke risk factors rather than traditional risks such as high blood pressure, according to research published today in Stroke, the peer-reviewed scientific journal of the American Stroke Association, a division of the American Heart Association.

17 Apr 2025

RFK Jr. struggles to navigate frustrated supporters and a demanding boss

After the Senate voted to confirm Robert F. Kennedy Jr. as Health and Human Services secretary, supporters of his "Make America Healthy Again" movement cheered at having a champion in the federal government.

17 Apr 2025

Humanized liver organoids double survival rate in rodent models

One reason why our livers excel at clearing waste from our blood system is that the organ functions according to three key "zones" that perform specific major tasks.

16 Apr 2025

Breakthrough method creates functional liver organoids

While organoids aim to mimic human organs, the liver's repertoire of complex functions – and thus the energy it needs to operate – have made it challenging for researchers to grow organoids that proliferate and fully function, says Sato. When prioritizing growth and survival in laboratory settings, hepatocytes, the liver's main cells, eventually transformed into cells resembling cholangiocytes, which line the bile duct.

16 Apr 2025

Gut bacteria turn bile acids into allies against cancer

Bacteria naturally present in the human intestine, known as the gut microbiota, can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking androgen signaling, according to a preclinical study led by Weill Cornell Medicine investigators.

16 Apr 2025

Multi-omics analysis uncovers molecular drivers of non-viral liver cancer development

Researchers discover that inflammation and aging contribute to non-viral liver cancer development. Green tea's role in reversing some of the pathway dysregulation that may contribute to the cancer development and other therapies explored.

15 Apr 2025

Sleep fragmentation in diabetes triggers lasting liver damage and cardiovascular risk

This new article publication from Acta Pharmaceutica Sinica B, discusses how diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH oxidase 4.

14 Apr 2025

What really causes keto flu, and how can you prevent it?

A scoping review from the University of Bergen identifies a wide range of transient symptoms—collectively known as "keto flu"—that occur during the initiation of a ketogenic diet. The review explores their physiological basis and highlights strategies, such as MCTs and electrolyte supplementation, to ease the transition.

13 Apr 2025

Adolescent obesity in England rises by 50% over 15 years

New research to be presented at this year's European Congress on Obesity (ECO 2025, Malaga, Spain, 11-14 May) shows that the proportion of adolescents living with overweight or obesity in England has increased by 50% from 2008-2010 (22%) to 2021-2023 (33%).

12 Apr 2025