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Additional inhibitor could be key to helping anti-VEGF therapies overcome resistance in glioblastoma

Adding another inhibitor to therapies that cut off a tumor's access to blood vessels could be the key to helping those therapies overcome resistance in glioblastoma, a deadly form of brain cancer.

27 Aug 2018

'Plastic antibodies' effectively target and eliminate tumor cells

A joint research team from Russia and the U.K. has demonstrated the possibility of developing a new type of anti-neoplastic drugs based on nanoMIPs, or "plastic antibodies." NanoMIPs are synthetic polymers that can function as antibodies, selectively binding to target proteins on the surface of cancer cells.

23 Aug 2018

Scientists design biomaterial that stimulates growth of blood vessels in teeth after root canal

A root canal ranks high on most people's list of dreaded dental procedures. Although the lengthy and sometimes painful surgery relieves the agony of an infection, a root canal results in a dead tooth with no living soft tissue, or dental pulp, inside.

22 Aug 2018

Researchers identify genes responsible for inherited breast cancer in Nigerian women

For the first time, DNA contributed by Sub-Saharan African women has been thoroughly evaluated with innovative genomics technology in an effort to understand the genetic bases for breast cancer in African populations.

22 Aug 2018

Study unravels cellular and molecular mechanisms behind dermal condensate formation

Hair growth is regulated by a small cluster of hair-specific fibroblasts, the dermal papilla. But exactly how dermal papilla forms has remained elusive until now.

20 Aug 2018

Immune cell found to play important role in photosensitivity

Researchers at Hospital for Special Surgery have discovered that a type of immune cell known as Langerhans appears to play an important role in photosensitivity, an immune system reaction to sunlight that can trigger severe skin rashes.

16 Aug 2018

UIC researchers receive NIH funding to develop a better way to regenerate bone or tissues

University of Illinois at Chicago researchers have received approximately $2 million in funding from the National Institutes of Health to develop a better way to regenerate bone or tissues that have been lost to disease or injury.

14 Aug 2018

Scientists discover key vulnerability of mixed lineage leukemia

Childhood leukemia is a diagnosis that no family ever wants to endure. While the treatment of most types of leukemia has improved steadily over the years, a few specific types remain very difficult to treat.

13 Aug 2018

Study: HDAC1 enzyme modifies molecular motor that drives neuron death

A biochemistry instructor curious about an enzyme discovered in the damaged neurons of people with multiple sclerosis made a leap toward a potential cure for countless neurodegenerative ills.

7 Aug 2018

Researchers uncover new mechanisms underlying common kidney cancer in children

Connecting two previously unrelated insights about the formation of pediatric kidney cancer, researchers at UT Southwestern Medical Center have uncovered the means by which the cancer continues to grow, providing potential targets for more effective treatments in the future.

2 Aug 2018

European Commission approves Pfizer’s first oncology biosimilar

Pfizer Inc. today announced the European Commission has approved TRAZIMERA, a biosimilar to Herceptin (trastuzumab), for the treatment of human epidermal growth factor overexpressing breast cancer and HER2 overexpressing metastatic gastric or gastroesophageal junction adenocarcinoma.

31 Jul 2018

Researchers investigate new treatment that is effective against recurrent breast cancers

What do one in five breast cancers have in common? Large amounts of a protein called HER2 (or human epidermal growth factor receptor 2).

30 Jul 2018

Scientists discover gene that predicts arthritis severity

Scientists have discovered a new gene that is associated with disease severity in rheumatoid arthritis. HIP1 produces an inflammatory molecule which drives RA.

26 Jul 2018

New combination approach may help crush resistance to treatment in lung cancer patients

New-generation lung cancer drugs have been effective in a large number of patients, but within about a year, the patients tend to develop resistance to the therapy.

26 Jul 2018

Phase 3 study of tanezumab in patients with osteoarthritis pain meets all three co-primary endpoints

Pfizer Inc. and Eli Lilly and Company today announced that a 16-week Phase 3 study in patients with osteoarthritis pain evaluating subcutaneous administration of tanezumab, an investigational humanized monoclonal antibody, met all three co-primary endpoints.

19 Jul 2018

Gene regulator associated with protein pileup in exfoliation glaucoma

In exfoliation glaucoma, a protein dandruff clogs the outflow pathway for the fluid in our eyes.

19 Jul 2018

FDA grants approval for first breast cancer drug through 'Real-Time Oncology Review'

The U.S. Food and Drug Administration today approved Kisqali (ribociclib) in combination with an aromatase inhibitor for the treatment of pre/perimenopausal or postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer, as initial endocrine-based therapy.

19 Jul 2018

Why men may recover more quickly from influenza infections than women

Men may recover more quickly from influenza infections because they produce more of a key lung-healing protein, a study from scientists at Johns Hopkins Bloomberg School of Public Health suggests.

17 Jul 2018

Clinical trial results of tucatinib with T-DM1 shows promise in treating HER2+ breast cancer

Phase 1b clinical trial results published in JAMA Oncology show promise for the combination of tucatinib with T-DM1 against heavily pretreated HER2-positive breast cancer.

11 Jul 2018

Ludwig-developed antibody drug for deadly brain cancer may have broader applications

A Ludwig Cancer Research study explains why a particular mutation in the epidermal growth factor receptor, a cell surface protein, results in more aggressive tumors and poorer overall survival of patients diagnosed with the brain cancer glioblastoma multiforme.

10 Jul 2018

Growth Factor News and Research

Additional inhibitor could be key to helping anti-VEGF therapies overcome resistance in glioblastoma

'Plastic antibodies' effectively target and eliminate tumor cells

Scientists design biomaterial that stimulates growth of blood vessels in teeth after root canal

Researchers identify genes responsible for inherited breast cancer in Nigerian women

Study unravels cellular and molecular mechanisms behind dermal condensate formation

Immune cell found to play important role in photosensitivity

UIC researchers receive NIH funding to develop a better way to regenerate bone or tissues

Scientists discover key vulnerability of mixed lineage leukemia

Study: HDAC1 enzyme modifies molecular motor that drives neuron death

Researchers uncover new mechanisms underlying common kidney cancer in children

European Commission approves Pfizer’s first oncology biosimilar

Researchers investigate new treatment that is effective against recurrent breast cancers

Scientists discover gene that predicts arthritis severity

New combination approach may help crush resistance to treatment in lung cancer patients

Phase 3 study of tanezumab in patients with osteoarthritis pain meets all three co-primary endpoints

Gene regulator associated with protein pileup in exfoliation glaucoma

FDA grants approval for first breast cancer drug through 'Real-Time Oncology Review'

Why men may recover more quickly from influenza infections than women

Clinical trial results of tucatinib with T-DM1 shows promise in treating HER2+ breast cancer

Ludwig-developed antibody drug for deadly brain cancer may have broader applications

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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