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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Gut microbes revealed as hidden drivers of aging and cellular decline

Gut microbiota-derived phenylacetylglutamine accelerates aging by driving cellular senescence through mitochondrial dysfunction and DNA damage, offering insights into therapeutic interventions for age-related decline.

14 Jan 2025

U.S. Department of Defense awards $11.9 million to OSU for drug delivery research

The U.S. Department of Defense has awarded up to $11.9 million to Oregon State University to invent new drug delivery technologies for protecting members of the military from a range of health threats in combat areas.

13 Jan 2025

Enhanced biosensing technology detects molecules at lower concentrations

An unplugged electric instrument may function, but it sounds much better when it is connected to an amplifier.

13 Jan 2025

Short-chain fatty acids propionate and butyrate directly modify chromatin to regulate gene expression

Short-chain fatty acids influence gene regulation and chromatin accessibility, highlighting their role in colorectal cancer and normal cellular processes.

13 Jan 2025

RNAConnect Debuts The New UltraMarathonRT® RT-qPCR Kit to Improve Reliability Of Gene Expression Analysis

UltraMarathonRT® RT-qPCR Kit offers unmatched data reliability and sensitivity for gene expression studies, streamlining workflows and preserving RNA integrity.

From RNAConnect 10 Jan 2025

New therapeutic target could boost CAR T-cell therapy success in solid tumors

Russell W. Jenkins, MD, PhD, a physician investigator in the Krantz Family Center for Cancer Research at the Mass General Cancer Center and an assistant professor of Medicine at Harvard Medical School, is senior author of a new study in Cancer Immunology Research, "TBK1 is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids".

10 Jan 2025

RNA nanoparticles offer dual action against prostate tumors

Yang Zhang, PhD, and Jinjun Shi, PhD, both of the Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women's Hospital, are co-senior authors of a paper published in ACS Nanoscience Au, "Lipid Nanoparticle Delivery of mRNA and siRNA for Concurrent Restoration of Tumor Suppressor and Inhibition of Tumorigenic Driver in Prostate Cancer."

10 Jan 2025

Researchers identify shared genes driving cancer spread

Cancer metastasis-the spread of cancer to other organs-is the leading cause of death among cancer patients. Researchers have now uncovered a "genetic signature" of 177 genes shared across multiple cancer types that drives this deadly process.

10 Jan 2025

How stress fuels allergic skin inflammation

Researchers investigate the cellular and molecular mechanisms through which stress exacerbates immunoglobulin E cutaneous allergic inflammation.

9 Jan 2025

Could camembert cheese hold the key to better memory?

Myristamide enhances cognitive function and BDNF in mice, indicating Camembert cheese's potential in combating cognitive decline and supporting brain health.

9 Jan 2025

Geneoscopy closes $105 M in Series C funding round to power next-generation of gastrointestinal diagnostic tests

Geneoscopy, Inc., a life sciences company focused on developing diagnostic tests for the advancement of gastrointestinal health, today announced the closing of a Series C funding round raising $105 million.

9 Jan 2025

New brain stem cell discovery could usher in better treatments for glioblastoma

The discovery of a new type of stem cell in the brain could usher in better treatments for the deadliest brain tumor.

8 Jan 2025

Researchers uncover molecular mechanisms driving RNA processing defects in Huntington's disease

A University of California, Irvine-led research team has discovered intricate molecular mechanisms driving the RNA processing defects that lead to Huntington's disease and link HD with other neurodegenerative disorders such as amyotrophic lateral sclerosis, frontotemporal lobar dementia and Alzheimer's disease.

8 Jan 2025