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Early scans reveal prostate radiotherapy toxicity risk

Daily scans taken during prostate cancer radiotherapy could be repurposed to guide changes to treatment, reducing the risk of side effects, a study suggests.

11 Dec 2025

Study reveals stepwise formation of cerebellar projections in the developing brain

A team of researchers at the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and Miguel Hernández University of Elche (UMH), has reconstructed for the first time how the cerebellum establishes its connections with the rest of the brain during the earliest stages of life.

11 Dec 2025

Researchers discover the enzyme responsible for chromothripsis in cancer

University of California San Diego researchers have discovered the enzyme responsible for chromothripsis, a process in which a single chromosome is shattered into pieces and rearranged in a scrambled order, allowing cancer cells to rapidly evolve and become resistant to treatment.

11 Dec 2025

AI-based tool may help personalize the treatment of patients with reduced coronary blood flow

Reduced coronary blood flow, measured with an artificial intelligence-based imaging tool, predicted future cardiovascular events in patients with suspected stable coronary artery disease.

11 Dec 2025

Researchers identify a distinct immuno-inflammatory biomarker across major psychiatric disorders

Individuals with psychiatric disorders exhibiting seemingly similar symptoms often respond very differently to the same treatment, suggesting that distinct biological processes are at work beneath the surface of similar clinical presentations.

11 Dec 2025

Interventions to treat valvular heart disease in cancer patients significantly improve survival

Valvular heart disease, identified through cardiovascular imaging, is common in cancer patients. Interventions to treat valvular heart disease significantly improved survival.

11 Dec 2025

AI model improves recurrence risk stratification in HR-positive, HER2-negative breast cancer

An artificial intelligence (AI) model created by integrating clinical, molecular, and histopathological data significantly improved recurrence risk stratification in hormone receptor (HR)-positive, HER2-negative breast cancer, according to results presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

10 Dec 2025

Study provides new insights into brain signaling during sleep and wakefulness

An international team led by the University of Michigan has introduced new methods that reveal which regions of the brain were active throughout the day with single-cell resolution.

10 Dec 2025

Addition of tucatinib to the standard of care delays disease progression in HER2-positive metastatic breast cancer

Adding tucatinib (Tukysa) to first-line maintenance therapy with trastuzumab (Herceptin) and pertuzumab (Perjeta) delayed disease progression in patients with HER2-positive metastatic breast cancer, potentially extending time off chemotherapy, according to results from the phase III clinical trial HER2CLIMB-05 presented at the San Antonio Breast Cancer Symposium (SABCS), held December 9-12, 2025.

10 Dec 2025

Study shines new light on how cancer avoids the mitotic stopwatch pathway

When cell division (mitosis) takes too long, it can be a sign that something is wrong with the cells, for example DNA damage or chromosomal instability.

10 Dec 2025

Researchers map how brain networks differ in individuals at high clinical risk for psychosis

Researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), and NHG Health's Institute of Mental Health (IMH) have mapped how brain networks differ in individuals at Clinical High Risk (CHR) for psychosis, providing a new perspective on the mechanisms underlying the disease onset.

10 Dec 2025

SIRT3 deficiency worsens eustachian tube dysfunction during middle-ear infection

Middle-ear infections caused by Gram-negative bacteria remain among the most common pediatric illnesses worldwide.

9 Dec 2025

Supportive marriages may shape appetite control through oxytocin and the brain–gut axis

Supportive marital relationships are associated with lower BMI, fewer food addiction symptoms, higher oxytocin, stronger frontal brain responses to food cues, and favorable gut tryptophan metabolites. These coordinated social, neural, hormonal, and gut pathways suggest a plausible biological link between emotional support and healthier eating regulation.

8 Dec 2025

Unified EEG imaging method improves accuracy in identifying epileptogenic zones

A new advance from Carnegie Mellon University researchers could reshape how clinicians identify the brain regions responsible for drug-resistant epilepsy.

8 Dec 2025

Lubiprostone shows signs of slowing kidney function decline in chronic kidney disease

In adults with stage IIIb–IV chronic kidney disease, the constipation drug lubiprostone did not reduce gut-derived uremic toxins but preserved creatinine-based kidney function over 24 weeks. The benefit was linked to microbiome remodeling, increased polyamine production, and improved mitochondrial function rather than toxin lowering.

8 Dec 2025

AI method could help clinicians accurately identify brain tumors and radiation necrosis

While targeted radiation can be an effective treatment for brain tumors, subsequent potential necrosis of the treated areas can be hard to distinguish from the tumors on a standard MRI.

8 Dec 2025

PTSD may be linked to accelerated brain aging among World Trade Center responders

Researchers from the Icahn School of Medicine at Mount Sinai have found that post-traumatic stress disorder (PTSD) may be linked to accelerated brain aging among World Trade Center (WTC) responders involved in rescue and recovery operations after the 9/11 terrorist attacks.

8 Dec 2025

JAX wins $30 million contract to create computational "digital twins" of the human heart

Developing new drugs is one of the riskiest and most expensive endeavors in science. Today, The Jackson Laboratory (JAX) announced a bold initiative to improve that trajectory, powered by an up to $30 million contract from the Advanced Research Projects Agency for Health (ARPA-H) Computational ADME-Tox and Physiology Analysis for Safer Therapeutics (CATALYST) program.

8 Dec 2025

Smartphone motor tests can predict dopamine deficiency in Parkinson’s disease without brain scans

Researchers explore the use of smartphones coupled with clinical scores to evaluate motor function and predict dopamine deficiency.

7 Dec 2025

$New targeted alpha therapy shows promise for patients with radioiodine-refractory thyroid cancer$

New targeted alpha therapy shows promise for patients with radioiodine-refractory thyroid cancer

A new targeted alpha therapy is showing promise for patients whose thyroid cancer no longer responds to radioactive iodine, the standard beta-emitting treatment. In a first-in-human study, investigators found that a single dose of the alpha-emitting radionuclide 211At (astatine) was both well-tolerated and effective, achieving disease control without molecularly targeted drugs.

5 Dec 2025

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Imaging News and Research

Early scans reveal prostate radiotherapy toxicity risk

Study reveals stepwise formation of cerebellar projections in the developing brain

Researchers discover the enzyme responsible for chromothripsis in cancer

AI-based tool may help personalize the treatment of patients with reduced coronary blood flow

Researchers identify a distinct immuno-inflammatory biomarker across major psychiatric disorders

Interventions to treat valvular heart disease in cancer patients significantly improve survival

AI model improves recurrence risk stratification in HR-positive, HER2-negative breast cancer

Study provides new insights into brain signaling during sleep and wakefulness

Addition of tucatinib to the standard of care delays disease progression in HER2-positive metastatic breast cancer

Study shines new light on how cancer avoids the mitotic stopwatch pathway

Researchers map how brain networks differ in individuals at high clinical risk for psychosis

SIRT3 deficiency worsens eustachian tube dysfunction during middle-ear infection

Supportive marriages may shape appetite control through oxytocin and the brain–gut axis

Unified EEG imaging method improves accuracy in identifying epileptogenic zones

Lubiprostone shows signs of slowing kidney function decline in chronic kidney disease

AI method could help clinicians accurately identify brain tumors and radiation necrosis

PTSD may be linked to accelerated brain aging among World Trade Center responders

JAX wins $30 million contract to create computational "digital twins" of the human heart

Smartphone motor tests can predict dopamine deficiency in Parkinson’s disease without brain scans

New targeted alpha therapy shows promise for patients with radioiodine-refractory thyroid cancer

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