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Drug combination shows promise for treating aggressive T-cell lymphomas

Relapsed/refractory peripheral and cutaneous T-cell lymphomas (R/R PTCL and CTCL) are aggressive blood cancers that often resist standard therapy. Patients with these lymphomas may require stem cell transplants, but the disease needs to be brought under control before patients can undergo this treatment.

2 Jul 2025

Advancing treatment for urothelial cancer with enfortumab vedotin and pembrolizumab

A new review was published in Volume 16 of Oncotarget on June 17, 2025, titled "Optimizing enfortumab vedotin plus pembrolizumab therapy."

2 Jul 2025

Danish trial reveals how structured exercise and guidance affect life with chronic conditions

A large multicenter trial found that a 12-week personalized exercise therapy and self-management support program produced a small but statistically significant improvement in health-related quality of life for adults with multimorbidity. The intervention was safe, but its clinical relevance remains uncertain, as only self-rated health showed a significant benefit over usual care.

1 Jul 2025

Spaceflight exposes astronauts to hidden threats in their gut

This review highlights how the unique stressors of space travel, radiation, microgravity, and circadian disruption impact astronauts’ gut microbiomes, with potential consequences for their mood, cognition, and immunity. The authors call for targeted microbiome monitoring and dietary interventions to protect astronaut mental health on future missions.

1 Jul 2025

Two-week social media news habits boost knowledge and trust

Following news on social media can enhance knowledge, belief accuracy, and trust, suggesting a path to a more informed society through verified content.

1 Jul 2025

Improving RNA drug delivery through intracellular traffic control

A recent study involving researchers from the University of Basel reveals that slowing down the intracellular transport of RNA-based drugs can significantly enhance their effectiveness.

1 Jul 2025

Shingles and RSV vaccines with AS01 adjuvant reduce dementia risk

Researchers found that older adults who received AS01-adjuvanted shingles or RSV vaccines had a significantly lower risk of developing dementia within 18 months compared to flu vaccine recipients. The protective effect is likely linked to the AS01 adjuvant itself, highlighting new avenues for dementia prevention.

30 Jun 2025

Study provides insights into the immune response following pig-to-human kidney xenotransplants

A pioneering study has provided unprecedented insights into the immune response following pig-to-human kidney xenotransplantation.

30 Jun 2025

Gene therapy shows promise for reducing stroke risk in patients with sickle cell disease

Gene therapy for sickle cell disease may help improve a major contributing factor to stroke risk in patients, reports a new study from St. Jude Children's Research Hospital.

30 Jun 2025

Coffee’s hidden compounds could help fight type 2 diabetes

A comprehensive review of nearly 150 studies reveals that coffee polyphenols may help regulate blood sugar and reduce inflammation linked to type 2 diabetes. However, most evidence comes from preclinical research, and robust clinical trials are needed to confirm benefits.

29 Jun 2025

Early therapy for preschool depression shows long lasting benefits

Depression affects 1%-2% of children younger than 13 in the U.S. and can arise as early as age 3, but a specialized therapeutic intervention can help preschool-aged children find relief from this condition - with benefits lasting at least four years, according to a new study led by researchers at Washington University School of Medicine in St. Louis.

27 Jun 2025

New study supports non-surgical approach for select cases of acute subdural hematoma

Acute subdural hematoma (ASDH) is a common brain lesion resulting from traumatic brain injuries and is associated with high mortality and morbidity.

27 Jun 2025

Advancing transdermal insulin delivery through innovative formulation strategies

Announcing a new publication for Acta Materia Medica journal. The prevalence of diabetes is increasing and expected to become a major global health burden.

27 Jun 2025

Study maps HER2 mutations in lung cancer patients from Northeastern Brazil

A new research paper was published in Volume 16 of Oncotarget on June 17, 2025, titled "Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights."

27 Jun 2025

Insilico Medicine begins clinical trial for AI-designed cancer drug ISM3412

Insilico Medicine, a clinical-stage biotechnology company driven by generative artificial intelligence (AI), today announces that the first patient has been dosed in a global multicenter clinical trial (NCT06414460) to evaluate ISM3412, a potentially best-in-class, AI-empowered MAT2A inhibitor with novel structure, in patients with locally advanced and metastatic solid tumors.

27 Jun 2025

Kennedy’s vaccine advisers sow doubts as scientists protest US pivot on shots

As fired and retired scientists rallied outside in the Atlanta heat, an advisory panel that Robert F. Kennedy Jr. handpicked to replace experts he'd fired earlier met inside the Centers for Disease Control and Prevention's headquarters to plan a more skeptical vaccine future.

27 Jun 2025

Study explores how a familiar spice tackles the toughest cancer cells

Researchers found that clinically achievable doses of curcumin, the active compound in turmeric, target and suppress colorectal cancer stem-like cells, especially in early adenomas. Curcumin shifts these cells toward differentiation, delays tumor growth in mice, and may offer a safe preventive strategy.

27 Jun 2025

Methylene blue emerges as an adjunct in septic shock

Recent evidence suggests methylene blue may help reduce vasopressor needs and ICU stays in septic shock, but current data do not support replacing standard therapies. Further research is needed to clarify its optimal dosing, timing, and patient selection for best outcomes.

26 Jun 2025

NANOSPRESSO device brings precision medicine to hospital pharmacies

A new gene therapy delivery device could let hospital pharmacies make personalized nanomedicines to order.

26 Jun 2025

Gut microbe emerges as a promising tool in the fight against COVID-19

Researchers found that Akkermansia muciniphila boosts lung-specific antiviral immunity against SARS-CoV-2 in mice by modulating the gut–lung axis. This commensal gut bacterium shows promise as a potential biomarker and biotherapeutic candidate for COVID-19 and other respiratory infections.

25 Jun 2025