Amyotrophic Lateral Sclerosis News and Research

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REM sleep suppression linked to longer survival in ALS patients

During REM sleep, the body enters a state of paralysis. This can pose a danger for patients with weakened diaphragms due to neuromuscular diseases.

21 May 2025

New Alzheimer's drug candidate reduces toxic protein and improves memory in mice models

As researchers work to improve treatment of Alzheimer's disease, new research by UCLA Health identified a candidate drug that reduces levels of a toxic form of a protein in the brain caused by the disease and improved memory in mice by boosting production of a protective protein.

20 May 2025

Peptide nanostructures block amyloid buildup and boost neuron survival in lab tests

Researchers developed trehalose-functionalized peptide amphiphiles (TPAs) that self-assemble into supramolecular nanostructures and demonstrated these TPAs can inhibit amyloid beta aggregation. In vitro, TPAs significantly improved survival of human neurons exposed to amyloid-induced neurotoxicity, suggesting therapeutic potential for neurodegenerative diseases.

15 May 2025

New approach directly combats the progression of Alzheimer’s and ALS

Scientists at Northwestern University have developed a new approach that directly combats the progression of neurodegenerative diseases like Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

14 May 2025

Mitochondrial DNA editing offers new hope for neurodegenerative disease treatment

Mitochondrial DNA (mtDNA) editing has emerged as a revolutionary approach in the fight against neurodegenerative diseases (NDDs).

12 May 2025

TDP-43 dysfunction in brain blood vessels may drive Alzheimer's and ALS progression

Reduced levels of a critical protein are linked to devastating brain diseases like Alzheimer's, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS). Surprisingly, the protein shortage primarily affects the brain's blood vessels.

30 Apr 2025

Computational biology uncovers RNA changes in ALS patients

Amyotrophic lateral sclerosis (ALS) is a disease that destroys the nerves necessary for movement. About 30,000 people in the United States are affected, and doctors still don't know what causes it.

25 Apr 2025

New approach may prevent neurotoxic protein aggregates in ALS

Researchers at Goethe University, Johannes Gutenberg University Mainz and Kiel University discover possible method for preventing protein aggregates – Cluster4Future PROXIDRUGS research project.

23 Apr 2025

Using AI to understand how the brain processes language during real-life conversations

We investigated how our brains process language during real-life conversations. Specifically, we wanted to understand which brain regions become active when we're speaking and listening, and how these patterns relate to the specific words and context of the conversation.

18 Apr 2025

Experimental drug NU-9 shows promise for Alzheimer's and ALS treatment

Experimental drug NU-9 - a small molecule compound approved by the U.S. Food and Drug Administration (FDA) for clinical trials for the treatment of amyotrophic lateral sclerosis (ALS) - improves neuron health in animal models of Alzheimer's disease, according to a new Northwestern University study.

8 Apr 2025

Proteins linked to Parkinson's and ALS found to protect mitochondria

Scientists at Johns Hopkins Medicine say they have discovered how a group of proteins linked to Parkinson's disease and amyotrophic lateral sclerosis act as "guardians" of mitochondria, small organelles, or subunits, within a cell that make and store energy and are found in almost all plants and animals.

8 Apr 2025

Scientists discover cellular mechanism to protect and repair mitochondria

Damage to the genetic material of mitochondria – the mitochondrial DNA or mtDNA for short – can lead to diseases such as Parkinson's, Alzheimer's, amyotrophic lateral sclerosis (ALS), cardiovascular diseases and type 2 diabetes.

4 Apr 2025

NUZ-001 shows positive results in human 3D brain model

Neurizon Therapeutics Limited (“Neurizon”), a clinical-stage biotech company dedicated to advancing treatments for neurodegenerative diseases, is pleased to advise that results from an independent study undertaken in collaboration with Tessara Therapeutics (“Tessara”) will be presented by the group’s Principal Scientist and Alzheimer’s Disease expert, Dr Mark Greenough at the AD/PD 2025 Advances in Sciences & Therapy conference on April 2nd to 3rd.

3 Apr 2025

ALL ALS Consortium creates a central information hub to accelerate ALS research

The Access for All in ALS (ALL ALS) Consortium announced the launch of its official website, creating a central hub for information about its initiatives and clinical research studies. ALL-ALS.org is designed to inform and engage researchers, clinicians, and current and prospective study participants.

31 Mar 2025

Cell's stress response is more nuanced and compartmentalized than previously thought

The body's cells respond to stress-toxins, mutations, starvation or other assaults-by pausing normal functions to focus on conserving energy, repairing damaged components and boosting defenses.

26 Mar 2025

Advanced imaging technique reveals how nuclear pores regulate molecular movement

Just as cities must carefully manage the flow of cars in and out of downtown, cells regulate the movement of molecules into and out of the nucleus.

22 Mar 2025

Advanced software improves cerebellum analysis for disease diagnosis

A team of researchers from the Universitat Politècnica de València (UPV) and the French National Centre for Scientific Research (CNRS) has developed the world's most advanced software to study the human cerebellum using high-resolution NMR images.

20 Mar 2025

New scientific clue could unlock key cellular pathway leading to neurodegenerative diseases

In Nature Neuroscience, UConn School of Medicine researchers have revealed a new scientific clue that could unlock the key cellular pathway leading to devastating neurodegenerative diseases like Alzheimer's disease, and the progressive damage to the brain's frontal and temporal lobes in frontotemporal degeneration (FTD) and the associated disease amyotrophic lateral sclerosis (ALS).

14 Mar 2025

Understanding the role of LSD1 in cellular processes and disease

A new review highlights the pivotal role of LSD1 (lysine-specific demethylase 1) in regulating critical cellular processes and its implications for human diseases.

8 Mar 2025

Evaluating the combined effect of electroacupuncture and Chinese herbal medicine on gut microbiota in ALS patients

Recent studies have highlighted a link between amyotrophic lateral sclerosis (ALS) and gut microbiota. This prospective study aimed to evaluate the effects of electroacupuncture combined with Chinese herbal medicine on gut microbiota and metabolomics in ALS patients.

7 Mar 2025