Gastrointestinal Tract News and Research

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Breakthrough discovery offers hope for more effective malaria treatment

Antimalarial drug resistance is a pressing issue in combating the spread of malaria worldwide. In a new study, researchers from Children's Hospital of Philadelphia (CHOP) discovered a key process where malarial parasites take up a human blood cell enzyme, which could provide a new approach for antimalarial treatment.

6 Mar 2025

Synthetic microbiome therapy offers new hope against C. difficile infections

A synthetic microbiome therapy, tested in mice, protects against severe symptoms of a gut infection that is notoriously difficult-to-treat and potentially life threatening in humans, according to a team of researchers at Penn State.

3 Mar 2025

Integrating video capsule endoscopy technology in probiotic research

To be decided by the editor

From Atlantia Clinical Trials 28 Feb 2025

"Normal" vitamin B12 levels may not prevent brain decline

Researchers identify associations between B12 levels currently accepted as normal and markers of neurological injury or impairment.

24 Feb 2025

Can the carnivore diet trigger kidney stones? Case study raises red flags

A case study in The American Journal of Clinical Nutrition examines how one patient’s switch to a carnivore diet increased kidney stone risk by raising calcium, uric acid, and oxalate levels while reducing protective citrate.

19 Feb 2025

Gut bacteria could one day serve as microscopic in-house pharmacists

Hundreds of different species of microbes live, laugh, and love in your gut. In the future, one of these might serve a new function: microscopic in-house pharmacist.

13 Feb 2025

Targeted polymersomes boost methotrexate efficacy for aggressive choriocarcinoma treatment

Researchers develop targeted polymersomes loaded with methotrexate for the treatment of gestational choriocarcinoma,

11 Feb 2025

New drug delivery system shows promise for treating choriocarcinoma

A new drug delivery system shows promise for treating a rare, aggressive form of cancer affecting pregnant women and new mothers, and it has potential with other cancers as well.

6 Feb 2025

Breakthrough in gene-editing with Cas12a for modeling human diseases

Australian cancer researchers are the first to establish a next-generation gene-editing tool for modeling and interrogating human disease.

31 Jan 2025

Study reveals how beneficial gut microbe breaks down mucus for health

A microbe found in the lower part of the gut that is associated with good health has been comprehensively analyzed and found to have a focused diet breaking down sugars locked away in mucus.

31 Jan 2025

Oral and gut bacteria in stroke patients associated with worse prognosis and mortality

A common bacteria usually found in the mouth and gastrointestinal tract, Streptococcus anginosis, may be abundant in the guts of people with stroke and is associated with a worse prognosis and increased risk of death, according to a preliminary study to be presented at the American Stroke Association's International Stroke Conference 2025.

30 Jan 2025

Study reveals abelacimab’s potential to improve anticoagulation safety for AFib patients

Abelacimab, a factor XI inhibitor, demonstrated a 62–69% reduction in major bleeding compared to rivaroxaban in atrial fibrillation patients at moderate-to-high stroke risk, with comparable safety and efficacy. While ischemic stroke rates were slightly higher, they were not statistically significant, warranting further phase 3 trials for confirmation.

23 Jan 2025

Scientists unveil global patterns in early-life gut microbial evolution

Scientists reveal that early-life gut microbiome development follows universal patterns, paving the way for new benchmarks in child health assessments.

15 Jan 2025

AI-designed drug shows promise for inflammatory bowel disease

Insilico Medicine ('Insilico'), a clinical-stage generative artificial intelligence (AI)-driven drug discovery and development company, today announces positive results from two Phase I studies in Australia and China of ISM5411, a novel gut-restricted and PHD specific Inhibitor designed and optimized with the support of Insilico's Chemistry42 commercially-available generative reinforcement learning platform, for Inflammatory Bowel Disease (IBD).

8 Jan 2025

Gut-targeted antidepressants: A novel approach to battling depression and anxiety

Most of us have experienced the effects of moods and emotions on our gastrointestinal tract, from "butterflies" in the stomach caused by nervousness to a loss of appetite when we're feeling blue.

11 Dec 2024

Microplastics detected in human blood linked to altered coagulation markers

Findings indicate microplastics in blood are linked to inflammation and coagulation markers, underscoring the need for reduced exposure and further research.

10 Dec 2024

Fungus found in the mouse stomach may hold a key to fungal evolution in the gut

A fungus discovered in the mouse stomach may hold a key to fungal evolution within the gastrointestinal tract, according to new research led by Weill Cornell Medicine investigators.

27 Nov 2024

Woman’s saliva could offer clues to stress and mental health during pregnancy

New research out of Michigan State University found that the number and type of microbes present in the saliva of pregnant women differ according to whether they are experiencing life stress and symptoms of anxiety, depression and post-traumatic stress disorder.

27 Nov 2024

Specific protein patterns can predict IBD up to 16 years before diagnosis

Scientists at örebro University have identified specific protein patterns in blood that can predict inflammatory bowel disease (IBD) up to 16 years before diagnosis.

26 Nov 2024

New oral peptide therapy offers hope for chronic abdominal pain

A research team at the University of Vienna, led by medicinal chemist Markus Muttenthaler, has developed a new class of oral peptide therapeutic leads for treating chronic abdominal pain.

22 Nov 2024