MicroRNA News and Research

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In genetics, microRNAs (miRNA) are single-stranded RNA molecules of 21-23 nucleotides in length, which regulate gene expression. miRNAs are encoded by genes from whose DNA they are transcribed but miRNAs are not translated into protein (i.e. they are non-coding RNAs); instead each primary transcript (a pri-miRNA) is processed into a short stem-loop structure called a pre-miRNA and finally into a functional miRNA. Mature miRNA molecules are partially complementary to one or more messenger RNA (mRNA) molecules, and their main function is to down-regulate gene expression.

The beneficial effects of regular physical activity on the cardiovascular profile in the elderly

The effect of regular physical activity (PA) on the microcirculatory functions and plasma antioxidant capacity in older athletes.

20 Oct 2023

Gestational dexamethasone exposure impairs learning and memory function across generations

This new article publication from Acta Pharmaceutica Sinica B, discusses how gestational dexamethasone exposure impacts hippocampal excitatory synaptic transmission and learning and memory function with transgenerational effects.

15 Oct 2023

Study uncovers novel therapeutic target for osteoblastic lesions in prostate cancer bone metastasis

In a study published in the journal Genes & Diseases, researchers from Army Medical University and Shenzhen University investigated the pivotal role of miR-18a-5p, a microRNA, in the development and progression of osteoblastic lesions resulting from prostate cancer (PCa) bone metastasis.

9 Oct 2023

Unlocking the code: BigRNA's deep learning model predicts RNA behavior

Researchers have developed BigRNA, a groundbreaking deep learning model capable of predicting RNA behavior, including tissue-specific expression and splicing, directly from genomic DNA sequences. The model excels in identifying pathogenic variants and could be a game-changer in the development of personalized RNA-based therapies for treating genetic diseases.

28 Sep 2023

Researchers discover how Zika virus persists in the placenta

Before SARS-CoV-2 and the COVID-19 pandemic, there was the Zika virus epidemic, lasting from 2015 to 2016. The Zika virus can cause serious birth defects and abnormalities.

26 Sep 2023

Key player in ovarian cancer may have implications for PCOS

Researchers explore the involvement and altered expression of BBOX1-AS1 and microRNA-19b in polycystic ovary syndrome.

26 Sep 2023

Study reveals how a tiny strand of RNA controls T-cell memory to recognize tumors

A team of researchers at the University of Massachusetts Amherst has shown that a single, small strand of microRNA, or miRNA, known as let-7, governs the ability of T-cells to recognize and remember tumor cells.

25 Sep 2023

New method detects microRNA targets at the level of single cells

MicroRNAs are small molecules that regulate gene activity by binding to and destroying RNAs produced by the genes.

21 Sep 2023

New device can help test treatments in patients with gliomas

The shape and size of a grain of rice, the new device can conduct dozens of experiments at once to study the effects of new treatments on some of the hardest-to-treat brain cancers.

7 Sep 2023

New cancer therapy shows promise in mouse models, slows or reverses tumor growth

A new cancer therapy developed by Purdue University researchers attacks tumors by tricking cancer cells into absorbing a snippet of RNA that naturally blocks cell division.

4 Sep 2023

New insights into the role of liver progenitor cells in liver cancer initiation

Primary liver cancers ranked as the sixth most commonly diagnosed cancers and the third leading cause of cancer-related death in 2020. Among all primary liver cancers, HCC is the most common cancer, accounting for more than 80% of cases with a 5-year survival rate of less than 10% in Western countries.

17 Aug 2023

The role of self-extracellular nucleic acids in neuroinflammation

Researchers explore the role of self-extracellular nucleic acids in diseases like stroke, multiple sclerosis, Alzheimer’s disease, and Parkinson’s disease.

14 Aug 2023

SARS-CoV-2 induces mitochondrial dysfunction in multiple organs

Since the beginning of the COVID-19 pandemic caused by the SARS-CoV-2 virus, researchers have been trying to determine why this virus creates such negative long-term effects compared with most coronaviruses.

9 Aug 2023

How effective is physical activity in alleviating obesity-related inflammation in diabetes?

Scientists determine whether physical activity can be used as an effective intervention to mitigate obesity-related inflammation in diabetes.

1 Aug 2023

Single target, multiple possibilities: microRNA holds promise for epilepsy treatment

Study investigated the role of micro-ribonucleic acid (miRNA) miR-335-5p as a potential therapeutic target for epilepsy.

25 Jul 2023

Study finds cell-free RNA can be used to predict preeclampsia

Preeclampsia is a serious pregnancy disorder, marked by high blood pressure and the presence of proteins in urine, affecting between 2% and 4% of pregnant women worldwide, leading to about 46,000 maternal deaths and about 500,000 fetal and newborn deaths each year.

20 Jul 2023

MicroRNA News and Research

Further Reading

The beneficial effects of regular physical activity on the cardiovascular profile in the elderly

Gestational dexamethasone exposure impairs learning and memory function across generations

Study uncovers novel therapeutic target for osteoblastic lesions in prostate cancer bone metastasis

Unlocking the code: BigRNA's deep learning model predicts RNA behavior

Researchers discover how Zika virus persists in the placenta

Key player in ovarian cancer may have implications for PCOS

Study reveals how a tiny strand of RNA controls T-cell memory to recognize tumors

New method detects microRNA targets at the level of single cells

New device can help test treatments in patients with gliomas

New cancer therapy shows promise in mouse models, slows or reverses tumor growth

New insights into the role of liver progenitor cells in liver cancer initiation

The role of self-extracellular nucleic acids in neuroinflammation

SARS-CoV-2 induces mitochondrial dysfunction in multiple organs

How effective is physical activity in alleviating obesity-related inflammation in diabetes?

Single target, multiple possibilities: microRNA holds promise for epilepsy treatment

Study finds cell-free RNA can be used to predict preeclampsia

Researchers create a multiclass cancer diagnostic model using miRNA expression profiles and AI

Study reveals potential target for repairing beta-cell dysfunction in Type 2 diabetes

Zebrafish study reveals how blood stem cells affect health

Children with mitochondrial disorders have weaker antibody response to viral infections, study finds

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