Apoptosis News and Research

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Apoptosis is programmed cell death, the body's normal method of disposing of damaged, unwanted, or unneeded cells.

Defect in DNA repair machinery causes underdevelopment of neural network

DNA is the computer code that programs every event in the body. Despite the importance of DNA fidelity, as the body develops, cells grow and replicate, DNA is constantly turned over. This repeated process can compromise the DNA, which is why the body has many DNA repair machineries.

30 Aug 2017

Study tests therapeutic effect of conventional and new cancer drug combinations

Cancer is one of the major causes of death worldwide affecting 8.2 million of people per year, and in the US, the number of new cases will achieve 1.6 million in 2017. The global impact of this disease costs a trillion of dollars, which makes critical the development of new drugs and treatment against it.

28 Aug 2017

Simultaneous treatment with anti-PD1 and anti-OX40 cancer therapies may have detrimental effect

Concurrent administration of the T-cell stimulating anti-OX40 antibody and the immune checkpoint inhibitor anti-PD1 antibody attenuated the effect of anti-OX40 and resulted in poor treatment outcomes in mice.

28 Aug 2017

Gut bacterium can stop chemotherapy from causing cancer cell death

Researchers at Michigan Medicine and in China showed that a type of bacterium is associated with the recurrence of colorectal cancer and poor outcomes.

27 Jul 2017

Researchers discover potential chemical 'silver bullet' to reduce risk of colon cancer

In preclinical experiments, researchers at VCU Massey Cancer Center have uncovered a new way in which colon cancer develops, as well as a potential "silver bullet" for preventing and treating it.

26 Jul 2017

Wistar scientists discover new therapeutic strategy for difficult-to-treat form of ovarian cancer

A potential new therapeutic strategy for a difficult-to-treat form of ovarian cancer has been discovered by Wistar scientists. The findings were published online in Nature Cell Biology.

24 Jul 2017

Research shows how dietary essential fatty acids can help treat Alzheimer’s, other diseases

Understanding how dietary essential fatty acids work may lead to effective treatments for diseases and conditions such as stroke, Alzheimer's disease, age-related macular degeneration, Parkinson's disease and other retinal and neurodegenerative diseases.

18 Jul 2017

Scientists gain new insights into protein network that regulates programmed cell death

Researchers use a simplified model of a protein network to explain how apoptosis is regulated, whose malfunction is linked to cancer and neurodegenerative diseases.

14 Jul 2017

Rhodanine-based compounds show inhibitory activity to prevent aggregation of Tau proteins

The design of tailored peptide-polymer conjugates as drug-specific formulation additives offers access to next generation precision additives that can render problematic small organic drugs water-soluble and improve bioavailability.

30 Jun 2017

Exposure to medical imaging radiation does not increase child’s cancer risk

In an article published in the June 2017 issue of The Journal of Nuclear Medicine, researchers assert that exposure to medical imaging radiation not only doesn't increase an adult person's risk of getting cancer, it doesn't increase a child's risk.

7 Jun 2017

Research into cellular senescence may lead to new ways of treating age-related disorders

One of the things that happens to our bodies as we age is that certain cells start to accumulate. So-called senescent cells – cells that "retire" and stop dividing but refuse to die – are always present, and they even serve some important functions, such as in wound repair.

18 May 2017

Study prompts further assessment of tomato extracts’ use in gastric cancer prevention

A new study shows that whole tomato extracts from two different Southern Italy cultivars inhibit gastric cancer cell growth and malignant features, paving the way for future studies aimed at implementing lifestyle habits not only for prevention but potentially as a support to conventional therapies.

15 May 2017

New spherical nucleic acid drug crosses blood-brain barrier to target brain tumors in animals

The first drug using spherical nucleic acids to be systemically given to humans has been developed by Northwestern University scientists and approved by the Food and Drug Administration as an investigational new drug for an early-stage clinical trial in the deadly brain cancer glioblastoma multiforme.

12 May 2017

Troponin elevations can occur in the absence of classic myocardial infarction, study shows

Elevated cardiac troponin, a diagnostic marker of damage to the heart, may occur even if a patient has not had a heart attack, according to a study published in JACC: Basic to Translational Science.

9 May 2017

Researchers develop hybrid nanomaterial for destruction of cancer cells

Most tumors contain regions of low oxygen concentration where cancer therapies based on the action of reactive oxygen species are ineffective.

4 May 2017

IDIBELL researchers reveal role of endoplasmic reticulum in cell death process due to starvation

Researchers from the Cell death group of the Bellvitge Biomedical Research Institute, led by Dr. Cristina Muñoz-Pinedo, have characterized the cell death process due to starvation, in which the endoplasmic reticulum plays a leading role.

3 May 2017

Researchers show how Epstein-Barr virus manages to persist inside immune system's B cells

Viruses are notorious for taking over their host's operations and using them to their own advantage. But few human viruses make themselves quite as cozy as the Epstein-Barr virus, which can be found in an estimated nine out of ten humans without causing any ill effects.

3 May 2017

Simple eye test can diagnose early signs of glaucoma

A SIMPLE eye test could help solve the biggest global cause of irreversible blindness, glaucoma. In clinical trials, the pioneering diagnostic -- developed by researchers at University College London and the Western Eye Hospital -- allowed doctors to see individual nerve cell death in the back of the eye.

27 Apr 2017

Johns Hopkins study shows that healthy adult gut loses and regenerates nerve cells

Johns Hopkins researchers today published new evidence refuting the long-held scientific belief that the gut nerve cells we're born with are the same ones we die with.

19 Apr 2017

TUM study shows link between zinc supply in the body and cardiac function

In addition to essential metabolic functions, the level of zinc in the body also affects the heart muscle. When oxidative stress occurs, it may be due to a shortage of zinc, which can be determined by examining the heart muscle.

18 Apr 2017