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Unleashing the potential of biological timekeeping

Living organisms monitor time – and react to it – in many different ways, from detecting light and sound in microseconds to responding physiologically in pre-programmed ways, via their daily sleep cycle, monthly menstrual cycle, or to changes in the seasons.

19 Dec 2024

New design could make seasonal influenza vaccinations more broadly effective

Stanford Medicine scientists have designed a way to make our seasonal influenza vaccinations more broadly effective and possibly to protect us from new flu variants with pandemic potential.

19 Dec 2024

Chemogenetic activation reveals male-female differences in stress resistance neural circuits

Subtle activation of a small subset of neurons in one region of the brain can make male mice resilient to, and even reverse, the detrimental effects of chronic stress. The same is true for female mice, but in a totally different region of the brain.

19 Dec 2024

Light and moderate wine consumption linked to lower risk of cardiovascular complications

Light and moderate consumption of wine is associated with a lower risk of cardiovascular complications, according to a multicenter study led by researchers from the University of Barcelona, the Hospital Clínic and the August Pi i Sunyer Biomedical Research Institute (IDIBAPS), the Physiopathology of Obesity and Nutrition Networking Biomedical Research Centre (CIBEROBN) and the University of Navarra (UNAV).

19 Dec 2024

Modified lipid nanoparticles for targeted mRNA delivery to the brain

Penn Engineers have modified lipid nanoparticles (LNPs) - the revolutionary technology behind the COVID-19 mRNA vaccines - to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons.

18 Dec 2024

Chemical compound lights up treatment-resistant cancers on imaging scans

Researchers have used a chemical compound to light up treatment-resistant cancers on imaging scans, in a breakthrough that could help medical professionals better target and treat cancer.

17 Dec 2024

Breakthrough in understanding influenza's protective coat opens path to new treatments

To fight the virus that causes influenza, one of the avenues being explored by scientists is the development of drugs capable of destabilizing its genome, made up of eight RNA molecules.

17 Dec 2024

Pioneering study shows promising results for cognitive treatment in Down syndrome

The ICOD (Improving Condition in Down syndrome) project, a pioneering study in addressing the cognitive difficulties associated with Down syndrome, has demonstrated the safety of treatment with the molecule AEF0217, developed by the French biotech Aelis Farma, as well as its effectiveness in improving cognitive function in these people.

17 Dec 2024

Targeting brain enzyme may offer new treatment for obesity

Endocannabinoids in the brain play a key role in food intake and energy use. Modulating the action of these molecules could help fight obesity, say researchers at Université de Montréal's affiliated hospital research center.

16 Dec 2024

Australian research unlocks new path for cancer immunotherapy

Australian-led research is unlocking new ways for immunotherapy to better target cancer.

14 Dec 2024

Promising combination therapy could improve liver cancer outcomes

Dan G. Duda, DMD, PhD, of the Edwin L. Steele Laboratories for Tumor Biology and Department of Radiation Oncology at Massachusetts General Hospital, is the corresponding author of a paper published in Cancer Immunology Research, "Combination CXCR4 and PD1 Blockade Enhances Intratumoral Dendritic Cell Activation and Immune Responses Against Hepatocellular Carcinoma."

14 Dec 2024

Insilico Medicine gets first clinical milestone payment of $10 million for XL309

Insilico Medicine ('Insilico'), a clinical-stage generative artificial intelligence (AI)-driven drug discovery and development company, today announced that it has received the first clinical milestone payment of $10 million for XL309 (previously known as ISM3091) from Exelixis.

12 Dec 2024

Fatty acids disrupt glutamate transporter function in brain cells

Glutamate transporters pump glutamate from the synaptic cleft back into brain cells after its release during neurotransmission.

12 Dec 2024

NIH funding supports innovative lupus research using DNA mimic molecules

Lupus causes chronic pain, fatigue, and potentially organ damage for 1.5 million Americans and is a challenge for researchers trying to find better treatments.

12 Dec 2024

Study uncovers brain mechanism behind empathetic responses

A specific brain mechanism modulates how animals respond empathetically to others' emotions. This is the latest finding from the research unit Genetics of Cognition, led by Francesco Papaleo, Principal Investigator at the Istituto Italiano di Tecnologia (IIT - Italian Institute of Technology) and affiliated with IRCCS Ospedale Policlinico San Martino in Genova.

12 Dec 2024

Implantable sensors aid in optimizing bone injury recovery

Tiny implantable sensors are helping University of Oregon researchers optimize the process of recovery from severe bone injuries.

12 Dec 2024

Skin-friendly bacteria could revolutionize vaccination

Imagine a world in which a vaccine is a cream you rub onto your skin instead of a needle a health care worker pushes into your one of your muscles.

11 Dec 2024

Study offers a potential pathway for safer, non-addictive pain management

Researchers from the National University of Singapore (NUS), in collaboration with Peking University, China, have made a discovery regarding the TRPV1 (transient receptor potential vanilloid 1) ion channel and its role in pain perception.

11 Dec 2024

New class of antivirals shows promise against multiple viruses

The arrival of Paxlovid in December 2021 marked another turning point in the COVID-19 pandemic - an effective antiviral that has since successfully treated millions.

11 Dec 2024

Elevated PGE2 levels drive age-related skin changes and cancer risk

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 21 on November 18, 2024, entitled, "Prostaglandin E2 regulates senescence and post-senescence neoplastic escape in primary human keratinocytes."

11 Dec 2024