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Diabetes drug holds promise of being developed into new treatment for Alzheimer's

A drug developed for diabetes could be used to treat Alzheimer's after scientists found it "significantly reversed memory loss" in mice through a triple method of action.

2 Jan 2018

Study suggests new target to treat prostate cancer

Hokkaido University researchers have uncovered a cellular protein that stabilizes a tumor promoting signaling pathway, suggesting a new target to treat prostate cancer.

22 Dec 2017

Tumor growth traits can influence response to cancer drugs, study finds

Individual tumors respond differently to cancer drugs, if at all. Until now, it remained a mystery why tumors have different reactions to the exact same therapy. But a new study at the USC Viterbi School of Engineering finds that tumor growth properties can influence response to cancer drugs.

21 Dec 2017

Researchers identify novel mechanism that protects from brain tumor

A group of researchers at the Spanish National Cancer Research Centre have identified a protein called RanBP6 as a new regulator of EGFR. In a paper published in Nature Communications they show how silencing of RanBP6 promoted glioma growth, by upregulating EGFR expression.

18 Dec 2017

Researchers identify mechanism that regulates signaling events leading to cancer metastasis

Understanding how cancer cells are able to metastasize -- migrate from the primary tumor to distant sites in the body -- and developing therapies to inhibit this process are the focus of many laboratories around the country.

18 Dec 2017

Excessive copper in diabetes impedes ability to make new blood vessels

It's a metal we worry thieves will steal from our air conditioners or power lines, but inside our bodies too much copper can result in a much larger loss.

18 Dec 2017

Extracellular vesicles can be used to effectively delay progression of kidney damage

Researchers have demonstrated for the first time that extracellular vesicles - tiny protein-filled structures - isolated from amniotic fluid stem cells (AFSCs) can be used to effectively slow the progression of kidney damage in mice with a type of chronic kidney disease.

15 Dec 2017

Fusion gene may be found in cSCC lesions on skin exposed frequently to the sun

A fusion gene is a single composite gene that is the result of the combination of two formerly independent genes. Researchers from Kumamoto University, Japan have determined that a particular fusion gene has a tendency to be found in cutaneous squamous cell carcinoma (cSCC) lesions on skin exposed frequently to the sun.

14 Dec 2017

Researchers use RNA nanotechnology to program exosomes for delivering effective cancer therapies

A new study shows that attaching antibody-like RNA nanoparticles to microvesicles can deliver effective RNA therapeutics such as small interfering RNA specifically to cancer cells.

13 Dec 2017

Study reveals novel molecular targets to improve chemotherapy’s efficiency against leukemia

Researchers from Instituto de Medicina Molecular João Lobo Antunes have found a mechanism through which certain types of leukemia resist chemotherapy, thus revealing novel molecular targets that may be used to improve the efficiency of this type of treatment.

12 Dec 2017

Study indicates decline in use of chemotherapy for early stage breast cancer patients

A study of nearly 3,000 women with early stage breast cancer indicates a recent, significant decline in the use of chemotherapy despite the lack of any change in national treatment recommendations or guidelines, according to researchers at the Stanford University School of Medicine and the University of Michigan.

11 Dec 2017

New first line combination therapy shows promising results in patients with advanced NSCLC

A new combination therapy for the first line treatment of advanced non-squamous non-small-cell lung cancer (NSCLC) improves progression-free survival (PFS), according to results of phase III IMpower150 trial presented at the ESMO Immuno Oncology Congress 2017.

7 Dec 2017

Brazilian researchers identify genes linked to melanoma progression

When researchers at the University of São Paulo in Brazil treated human melanoma cell lines with a synthetic compound similar to curcumin, one of the pigments that give turmeric its orange color, they identified genes with altered expression in potentially invasive tumors and malignant cells resistant to chemotherapy.

6 Dec 2017

Overcoming Challenges of Assays of Complex Cellular Models with Real-Time Live-Cell Analysis

There's a continued drive towards making in vitro assays ever more translational towards in vivo models and ultimately the clinic. This ties in with the resurgence of phenotypic screening and is a response to the perceived poor translation of the traditional simple cell-based assays, often developed to study just single protein targets.

From Sartorius 5 Dec 2017

New study tests pain treatment in humans

Nerve growth factor signals through receptors of the tropomyosin-related kinase (Trk) family, and research in animals has shown that inhibitors of Trks A, B, and C can reduce pain.

27 Nov 2017

Study identifies signaling pathway essential for growth of new blood vessels

A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies a signaling pathway that is essential for angiogenesis, the growth of new blood vessels from pre-existing vessels.

23 Nov 2017

Small protein modification can trigger invasive properties of prostate cancer cells, research finds

A small protein modification can trigger the aggressive migratory and invasive properties of prostate cancer cells, according to new research published on the cover of Oncotarget. The findings give greater insight into how cancers can move from one location in the body to another, and could help develop more effective therapies in the future.

22 Nov 2017

Genetic diversity of tumor tissues can be barrier to precision medicine in gastric and esophageal cancers

A new study focused on describing genetic variations within a primary tumor, differences between the primary and a metastatic branch of that tumor, and additional diversity found in tumor DNA in the blood stream could help physicians make better treatment choices for patients with gastric and esophageal adenocarcinoma.

15 Nov 2017

Absence of VEGF-A in cancer-killing T cells accelerates tumor development

Contrary to what was previously believed, the immune system's cancer-killing T cells are more effective in a tumour's anoxic environment when they have access to growth factor VEGF-A.

13 Nov 2017

Largest clinical specialty database powers studies that yield key insights

The American Academy of Ophthalmology today announced key milestones and clinical insights from studies powered by its clinical database.

13 Nov 2017

Growth Factor News and Research

Diabetes drug holds promise of being developed into new treatment for Alzheimer's

Study suggests new target to treat prostate cancer

Tumor growth traits can influence response to cancer drugs, study finds

Researchers identify novel mechanism that protects from brain tumor

Researchers identify mechanism that regulates signaling events leading to cancer metastasis

Excessive copper in diabetes impedes ability to make new blood vessels

Extracellular vesicles can be used to effectively delay progression of kidney damage

Fusion gene may be found in cSCC lesions on skin exposed frequently to the sun

Researchers use RNA nanotechnology to program exosomes for delivering effective cancer therapies

Study reveals novel molecular targets to improve chemotherapy’s efficiency against leukemia

Study indicates decline in use of chemotherapy for early stage breast cancer patients

New first line combination therapy shows promising results in patients with advanced NSCLC

Brazilian researchers identify genes linked to melanoma progression

Overcoming Challenges of Assays of Complex Cellular Models with Real-Time Live-Cell Analysis

New study tests pain treatment in humans

Study identifies signaling pathway essential for growth of new blood vessels

Small protein modification can trigger invasive properties of prostate cancer cells, research finds

Genetic diversity of tumor tissues can be barrier to precision medicine in gastric and esophageal cancers

Absence of VEGF-A in cancer-killing T cells accelerates tumor development

Largest clinical specialty database powers studies that yield key insights

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

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