Protein C News and Research

RSS

Melanoma’s excessive mitochondrial dependence becomes a therapeutic vulnerability

Researchers have discovered that the most aggressive melanomas, the deadliest form of skin cancer, overactivate two key processes in mitochondria, the components of cells that provide energy.

23 Jun 2025

Researchers turn a deadly fungus into potent cancer-fighting compound

Penn-led researchers have turned a deadly fungus into a potent cancer-fighting compound. After isolating a new class of molecules from Aspergillus flavus, a toxic crop fungus linked to deaths in the excavations of ancient tombs, the researchers modified the chemicals and tested them against leukemia cells.

23 Jun 2025

Scientists discover on/off gene switches that could revolutionize personalized medicine

Scientists identified 473 human genes that act as genetic “on/off switches,” shaping disease risk through tissue-specific or universal patterns regulated by DNA changes and hormones. These findings could pave the way for more precise diagnostics and personalized therapies across cancers, immune, skin, and metabolic diseases.

22 Jun 2025

Men lose more weight than women on the keto diet, new study reveals why

Men lose more weight than women on a ketogenic diet, according to a comprehensive review in Frontiers in Nutrition. Sex differences in hormones, metabolism, and fat distribution influence the effectiveness of the ketogenic diet for obesity.

22 Jun 2025

Breakthrough study maps hidden protein dynamics in cancer cells

A team of international researchers led by scientists at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States, with its National Medical Center named a Top 5 "Best Hospital" in the nation for cancer care by U.S. News & World Report, provide the most thorough account yet of an elusive target for cancer treatment.

20 Jun 2025

Scientists identify novel combination therapy approach to treat pediatric acute myeloid leukemia

Scientists at St. Jude Children's Research Hospital and Dana-Farber Cancer Institute today report the identification of a novel combination therapy approach to treat pediatric acute myeloid leukemia (AML).

20 Jun 2025

New lab method accelerates diagnosis of genetic disorders of the immune system

A new laboratory method developed by researchers at Columbia University Vagelos College of Physicians and Surgeons may now help physicians more quickly diagnose patients with suspected genetic disorders of the immune system, many who have been trapped in diagnostic limbo for years.

20 Jun 2025

Researchers find unique genetic profile in childhood cancer survivors with cardiomyopathy

Scientists at St. Jude Children’s Research Hospital studied how common and rare genetic variants influence late-onset cardiomyopathy risk, highlighting the unique genetic complexity of childhood cancer survivors.

20 Jun 2025

Trial shows limited bone protection from weighted vests or resistance training in older adults

A new randomized clinical trial, led by a team of researchers from Wake Forest University School of Medicine and Wake Forest University, did not find evidence that wearing a weighted vest or engaging in resistance training prevented bone loss in older adults undergoing intentional weight loss.

20 Jun 2025

Histone modification involved in chromosome and spindle stabilization in mouse oocytes

The accurate distribution of chromosomes in an oocyte is essential for the correct transmission of genetic information to the next generation.

20 Jun 2025

Discovery of key protein reveals why exercise strengthens muscles and bones

"Exercise is good for your health" is a well-known phrase, but few people can clearly explain how and why it benefits the human body."

20 Jun 2025

Targeting ST6Gal-I shows promise in reducing Alzheimer’s disease pathology

A recent study published in Engineering has provided novel insights into the involvement of α2,6-sialylation in Alzheimer's disease (AD), revealing that the ablation of α2,6-sialyltransferase-I (ST6Gal-I), an enzyme responsible for α2,6-sialylation, can downregulate BACE1 expression and suppress the production of amyloid-β42 (Aβ42) plaques, which are hallmarks of AD.

20 Jun 2025

Targeted nanoparticles enable in vivo production of CAR T cells for cancer therapy

Researchers present a new method to safely and preferentially generate CAR T cells directly inside the body using targeted lipid nanoparticles that deliver mRNA directly to T cells.

20 Jun 2025

New nanoparticle system improves drug delivery for cancer treatment

Scientists at Xi'an Jiaotong-Liverpool University (XJTLU) and Nanjing University in China have developed a new drug delivery system that could improve how treatments of cancers and other diseases are delivered.

20 Jun 2025

AI reveals how H5N1 virus is evolving to evade human immunity

The H5N1 avian influenza virus has infected birds and mammals around the world. As of June 2025, 70 people have been infected, and 1 person has died in the United States.

20 Jun 2025

Targeting IGF2BP1 offers a new approach to cancer therapy

The RNA-binding protein IGF2BP1 has emerged as a key regulator of cancer hallmarks, influencing tumor proliferation, metastasis, immune evasion, and resistance to cell death.

20 Jun 2025

New 3D immunohistochemistry method enhances deep tissue imaging

Three dimensional immunohistochemistry (3D-IHC) has transformed our ability to visualize the spatial arrangement of cells and molecules in intact tissues.

19 Jun 2025

Autoantibodies against vinculin linked to childhood kidney disease

Idiopathic nephrotic syndrome (INS) is a serious kidney disease in children with no clear cause. In a recent study, researchers have identified a novel autoantibody targeting vinculin—a protein crucial for kidney cell structure—as a significant factor in INS.

19 Jun 2025

Herpes virus reshapes the human genome's architecture to aid its replication

Viruses are entirely dependent on their hosts to reproduce. They ransack living cells for parts and energy and hijack the host's cellular machinery to make new copies of themselves.

19 Jun 2025

Why Alzheimer’s DNA tests don’t treat all populations equally

A major global study tested whether European-derived polygenic risk scores (PGS) for Alzheimer’s disease can predict risk across diverse populations. While PGS performed well in many groups, it was less accurate in individuals of sub-Saharan African and Indian ancestry, highlighting the urgent need for more inclusive genetic data.

19 Jun 2025