Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

A new deep learning approach to predict disease-associated mutations

During the past years, artificial intelligence (AI) -- the capability of a machine to mimic human behavior -- has become a key player in high-techs like drug development projects.

28 Dec 2019

Recommended amounts of physical activity associated with reduced risk for seven cancers

A pooled analysis of nine prospective studies involving more than 750,000 adults finds that recommended amounts of leisure-time physical activity were linked to a lower risk for seven cancers, with several cancer types having a 'dose/response' relationship.

27 Dec 2019

Inserting end-modified DNA fragments with CRISPR-Cas9 yields highest efficiency

University of Illinois researchers achieved the highest reported rates of inserting genes into human cells with the CRISPR-Cas9 gene-editing system, a necessary step for harnessing CRISPR for clinical gene-therapy applications.

23 Dec 2019

Immunosupressant combination therapy for glioblastoma shows promise

Researchers from the University of Texas have found an immunosuppressing target for the treatment of glioblastoma. In mice studies the team has identified CD73 macrophages which could be used to treat the cancers. The team also performed studies on human tumours to arrive at their conclusions. The study was published in the latest issue of the journal Nature Medicine this week.

23 Dec 2019

Texas law highlights dilemma over care for patients with no hope of survival

Critically ill Tinslee Lewis - a Fort Worth baby embroiled in a dispute between her family and a hospital over whether to continue life-sustaining treatment - is the most recent public face of the heartbreaking and intractable dilemmas often confronted quietly in intensive care units.

23 Dec 2019

New software helps prevent ICU delirium and improve patient outcomes

Intensive care unit delirium, a fertile area of clinical research and patient care innovation associated with Vanderbilt University Medical Center, is beginning to reshape how commercial electronic health record systems are engineered with regard to intensive care.

22 Dec 2019

Using hearts from hepatitis C-positive donors presents an opportunity to expand donor pool

Patients who were transplanted with hearts from hepatitis C-positive donors had comparable outcomes after one year to patients who received hearts from donors that didn't have the disease, according to a Vanderbilt University Medical Center study published in JAMA Cardiology.

22 Dec 2019

UTHealth scientist receives NIH grants for liver injury research

Tiny solutions are being sought for big liver problems by a scientist at McGovern Medical School at The University of Texas Health Science Center at Houston.

21 Dec 2019

Sphingotec's penKid is a reliable marker for detection and monitoring of acute kidney injury

Diagnostics company SphingoTec GmbH today reported on the publication of novel study results of its proprietary kidney function biomarker penKid® in BMC Emergency Medicine.

21 Dec 2019

p53 may play a more important role in kidney cancer than previously thought

The p53 gene, which researchers had thought was less relevant in kidney cancer, may play an important role after all – a discovery that could lead to new treatments.

20 Dec 2019

Jefferson researcher probes kidney cancer's genes for interactions with p53 pathway

p53 is the most famous cancer gene, not least because it's involved in causing over 50% of all cancers. When a cell loses its p53 gene -- when the gene becomes mutated -- it unleashes many processes that lead to the uncontrolled cell growth and refusal to die, which are hallmarks of cancer growth.

20 Dec 2019

Triple transplant patients encourage people to register as organ and tissue donors

Four University of Chicago Medicine patients who received rare triple-organ transplants came together publicly for the first time to encourage people to register as organ and tissue donors, hoping to raise awareness about giving the gift of life during a holiday season focused on giving.

20 Dec 2019

Researchers examine safety-net care for patients initiating maintenance dialysis in the U.S.

New research indicates that non-profit/independently-owned and hospital-based dialysis facilities care disproportionately for uninsured patients with kidney failure and those who quality only for Medicaid. The findings appear in an upcoming issue of JASN.

19 Dec 2019

Study finds differences in dialysis mortality for racial/ethnic groups in U.S. territories and states

A recent analysis found differences in mortality rates for various racial/ethnic groups among patients undergoing dialysis in the U.S. territories vs. the 50 U.S. states. The findings, which appear in an upcoming issue of CJASN, point to the need for research into the causes of these disparities.

19 Dec 2019

New antibody shows promise in active lupus

A new trial involving the use of an antibody called anifrolumab reports improvement in patients with systemic lupus erythematosus (SLE) after 52 weeks of treatment. The research, titled 'Trial of Anifrolumab in Active Systemic Lupus Erythematosus', is published in the New England Journal of Medicine.

19 Dec 2019

The number of people who need renal replacement therapy is increasing

The ERA-EDTA Registry collects data on renal replacement therapy from the national and regional renal registries in Europe and from countries bordering the Mediterranean. For the 2017 Annual Report, data sets from 53 national or regional renal registries in 37 countries were compiled. A total population of 694,024,000 people was analyzed.

19 Dec 2019

Scientists create new classification system for tumors

Based on the largest study of cancer patients of its kind, scientists have created a new way of classifying tumors.

19 Dec 2019

Routine cardiac stress test turns into lifesaving gift

Erika Hosey, a cardiovascular technician at University Hospitals Ahuja Medical Center, ended the year by giving a life-changing gift to a patient in need. While performing a routine cardiac stress test, she drummed up a conversation. She learned that her patient, Denise Butvin, had kidney disease and needed transplant surgery.

19 Dec 2019

Researchers discover a way to move precision immunotherapy forward for multiple myeloma

Researchers at the Icahn School of Medicine at Mount Sinai have discovered a way to move precision immunotherapy forward by using genomics to inform immunotherapy for multiple myeloma, a blood cancer, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research, in December.

19 Dec 2019

New review provides guidance to address gaps in transgender health care

One of the biggest barriers to care for transgender individuals is a lack of knowledgeable providers.

19 Dec 2019

Nephrology News and Research

Further Reading

A new deep learning approach to predict disease-associated mutations

Recommended amounts of physical activity associated with reduced risk for seven cancers

Inserting end-modified DNA fragments with CRISPR-Cas9 yields highest efficiency

Immunosupressant combination therapy for glioblastoma shows promise

Texas law highlights dilemma over care for patients with no hope of survival

New software helps prevent ICU delirium and improve patient outcomes

Using hearts from hepatitis C-positive donors presents an opportunity to expand donor pool

UTHealth scientist receives NIH grants for liver injury research

Sphingotec's penKid is a reliable marker for detection and monitoring of acute kidney injury

p53 may play a more important role in kidney cancer than previously thought

Jefferson researcher probes kidney cancer's genes for interactions with p53 pathway

Triple transplant patients encourage people to register as organ and tissue donors

Researchers examine safety-net care for patients initiating maintenance dialysis in the U.S.

Study finds differences in dialysis mortality for racial/ethnic groups in U.S. territories and states

New antibody shows promise in active lupus

The number of people who need renal replacement therapy is increasing

Scientists create new classification system for tumors

Routine cardiac stress test turns into lifesaving gift

Researchers discover a way to move precision immunotherapy forward for multiple myeloma

New review provides guidance to address gaps in transgender health care

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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