Macrophage News and Research

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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

Study unravels novel cellular and molecular pathway that regulates innate, adaptive immunity

Researchers at Brigham and Women's Hospital have discovered a new cellular and molecular pathway that regulates CD4+ T cell response--a finding that may lead to new ways to treat diseases that result from alterations in these cells.

24 Feb 2018

Scientists discover new treatment approach to curb severe myocarditis

The outcome of viral myocarditis is closely associated with the immune response of the affected individual. An inhibitor of the immunoproteasome, a protein degradation complex in immunocompetent cells, reduces the extent of the inflammation and thus also the damage to the heart during myocarditis.

22 Feb 2018

Research opens up new avenue to minimize risks of transplants

A bone marrow transplant is often the only therapy available to save leukemia patients, but the risk of complications is high. In spite of devoting considerable time and effort to finding a suitable donor, nearly half of all patients experience an unwanted reaction of their immune system, which often attacks their skin and liver and in up to 50% of cases the intestines.

21 Feb 2018

Bioactive compound limits collateral damage in the kidneys after heart attack

A heart attack triggers an acute inflammatory response at the damaged portion of the heart's left ventricle. If this acute inflammation lingers, it can lead to stretching of the ventricle and heart failure. The inflammation can claim another victim -- the kidneys.

21 Feb 2018

MGH researchers discover that macrophages contribute to untreatable type of heart failure

A team of Massachusetts General Hospital investigators has discovered, for the first time, that the immune cells called macrophages contribute to a type of heart failure for which there currently is no effective treatment.

14 Feb 2018

New tool measures cell strength 100 times faster than current technologies

Engineers, doctors and scientists at UCLA and Rutgers University have developed a tool that measures the physical strength of individual cells 100 times faster than current technologies.

12 Feb 2018

Findings reveal dramatic landscape of genetic changes in the brain in response to visual stimulation

"Nature and nurture is a convenient jingle of words, for it separates under two distinct heads the innumerable elements of which personality is composed.

9 Feb 2018

Special protein improves survival and lung function of mice with influenza, study shows

GM-CSF, a protein that modifies the immune response to the flu, may also help reduce lung inflammation and improve survival during influenza, according to Penn State researchers.

8 Feb 2018

Endogenous peptide improves glucose and insulin tolerance and reduces body weight in mice

Treating obese mice with catestatin, a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight, report University of California San Diego School of Medicine researchers.

7 Feb 2018

Novel grape-derived compounds could be developed as therapeutic agents for treatment of depression

In a study to be published online February 2 in Nature Communications, scientists from the Icahn School of Medicine at Mount Sinai describe an extensive analysis of novel grape-derived compounds, dihydrocaffeic acid (DHCA) and malvidin-3'-O-glucoside (Mal-gluc),which might be developed as therapeutic agents for the treatment of depression.

2 Feb 2018

New modular platform offers robust biological approach that targets endless number of diseases

The biological complexity of cancer and other diseases demands a more formidable arsenal of therapies than currently available. Most therapeutic approaches ignore the dynamic molecular network of genes, targeting instead only very few selected disease-related genes.

1 Feb 2018

Role of genetics behind immune disease risk could be missed, scientists suggest

The role of genetics in the risk of having an immune disease could be missed in research, scientists suggest.

29 Jan 2018

Study finds specific protein that plays role in breast cancer metastasis

Researchers from the University of Liverpool have found an explanation for how breast cancer spreads to the lungs, which could potentially hold the key to preventing the progression of the disease.

25 Jan 2018

Study reveals key role of macrophages in systemic sclerosis

A new international study has made an important discovery about the key role of macrophages, a type of immune cell, in systemic sclerosis (SSc), a chronic autoimmune disease which currently has no cure.

19 Jan 2018

Scientists discover new enzyme that could help in the battle against obesity

Scientists have discovered a new enzyme in adipose tissue that helps regulate inflammation. The discovery could help in the battle against obesity.

15 Jan 2018

Researchers discover new weapon to combat tuberculosis

Tuberculosis (TB), an infectious disease which attacks the lungs, claims someone's life every 20 seconds and 1.5 million lives worldwide every year.

11 Jan 2018

Study identifies enzyme that regulates inflammation and metabolism in fat tissue

The human body has two primary kinds of fat--white fat, which stores excess calories and is associated with obesity, and brown fat, which burns calories in order to produce heat and has garnered interest as a potential means of combating obesity.

11 Jan 2018

Macrophage nanosponges offer promising solution for effectively managing sepsis

A team of researchers at the University of California San Diego has developed macrophage "nanosponges" that can safely absorb and remove molecules from the bloodstream that are known to trigger sepsis.

4 Jan 2018

Arterial stiffness improves with high doses of vitamin D supplementation, study finds

In just four months, high-doses of vitamin D reduce arterial stiffness in young, overweight/obese, vitamin-deficient, but otherwise still healthy African-Americans, researchers say.

2 Jan 2018

Macrophages play major role in helping early breast cancer cells spread even before tumor develops

Mount Sinai researchers have discovered that normal immune cells called macrophages, which reside in healthy breast tissue surrounding milk ducts, play a major role in helping early breast cancer cells leave the breast for other parts of the body, potentially creating metastasis before a tumor has even developed, according to a study published in Nature Communications.

2 Jan 2018

Macrophage News and Research

Further Reading

Study unravels novel cellular and molecular pathway that regulates innate, adaptive immunity

Scientists discover new treatment approach to curb severe myocarditis

Research opens up new avenue to minimize risks of transplants

Bioactive compound limits collateral damage in the kidneys after heart attack

MGH researchers discover that macrophages contribute to untreatable type of heart failure

New tool measures cell strength 100 times faster than current technologies

Findings reveal dramatic landscape of genetic changes in the brain in response to visual stimulation

Special protein improves survival and lung function of mice with influenza, study shows

Endogenous peptide improves glucose and insulin tolerance and reduces body weight in mice

Novel grape-derived compounds could be developed as therapeutic agents for treatment of depression

New modular platform offers robust biological approach that targets endless number of diseases

Role of genetics behind immune disease risk could be missed, scientists suggest

Study finds specific protein that plays role in breast cancer metastasis

Study reveals key role of macrophages in systemic sclerosis

Scientists discover new enzyme that could help in the battle against obesity

Researchers discover new weapon to combat tuberculosis

Study identifies enzyme that regulates inflammation and metabolism in fat tissue

Macrophage nanosponges offer promising solution for effectively managing sepsis

Arterial stiffness improves with high doses of vitamin D supplementation, study finds

Macrophages play major role in helping early breast cancer cells spread even before tumor develops

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