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Johns Hopkins scientists find a way to prevent atherosclerosis

Working with mice and rabbits, Johns Hopkins scientists have found a way to block abnormal cholesterol production, transport and breakdown, successfully preventing the development of atherosclerosis, the main cause of heart attacks and strokes and the number-one cause of death among humans. The condition develops when fat builds inside blood vessels over time and renders them stiff, narrowed and hardened, greatly reducing their ability to feed oxygen-rich blood to the heart muscle and the brain.

23 Apr 2014

NeuroPhage engineers series of molecules with potential to treat most neurodegenerative diseases

Researchers from NeuroPhage Pharmaceuticals, Inc. have engineered a series of molecules with the potential to treat most neurodegenerative diseases that are characterized by misfolded proteins, such as Alzheimer's, Parkinson's and Huntington's diseases.

23 Apr 2014

Pfizer reports positive results from two tofacitinib Phase 3 trials for moderate-to-severe plaque psoriasis

Pfizer Inc. announced today top-line results from two pivotal Phase 3 trials from the Oral treatment Psoriasis Trials (OPT) Program, OPT Pivotal #1 (A3921078) and OPT Pivotal #2 (A3921079), evaluating the efficacy and safety of tofacitinib, an oral Janus kinase (JAK) inhibitor, the first in a new class of medicines being investigated for the treatment of moderate-to-severe plaque psoriasis.

23 Apr 2014

IMPAKT breast cancer conference abstracts online

Xenografts and mathematical modelling; liquid biopsy; nanotechnology; next generation genomics- Science is running fast and the impact of new technologies in the care of patients with breast cancer will be at the core of the sixth edition of the IMPAKT conference on translational research in breast cancer.

22 Apr 2014

Can-Fite BioPharma signs agreement with Smart Assays to develop A3AR predictive biomarker kit

Can-Fite BioPharma Ltd., a biotechnology company with a pipeline of proprietary small molecule drugs that address inflammatory and cancer diseases, announced today it has signed an agreement with Smart Assays to develop a commercial biomarker blood test kit for the A3 adenosine receptor (A3AR).

21 Apr 2014

Sarepta Therapeutics plans to submit eteplirsen NDA for treatment of Duchenne muscular dystrophy

Sarepta Therapeutics, Inc., a developer of innovative RNA-based therapeutics, today announced it plans to submit a New Drug Application (NDA) to the U.S. Food and Drug Administration by the end of 2014 for the approval of eteplirsen for the treatment of Duchenne muscular dystrophy (DMD).

21 Apr 2014

FDA and EC grant Orphan Drug Designation to Boehringer’s volasertib for acute myeloid leukemia

Boehringer Ingelheim Pharmaceuticals, Inc. announced today that the U.S. Food and Drug Administration (FDA) and European Commission (EC) have granted Orphan Drug Designation to volasertib for acute myeloid leukemia (AML).

21 Apr 2014

IV-administered ketamine effective in patients with chronic PTSD

For the first time, evidence that a single dose of IV-administered ketamine was associated with the rapid reduction of symptoms of post-traumatic stress disorder in patients with chronic PTSD was demonstrated in a proof-of-concept, randomized, double blind crossover study, undertaken by researchers at the Icahn School of Medicine at Mount Sinai in New York City. These findings, according to Mount Sinai researchers, could be the first step toward developing new interventions for PTSD.

21 Apr 2014

Genoa Pharmaceuticals, McMaster University report additional benefits of GP-101 for IPF patients

Genoa Pharmaceuticals, the leader in inhaled medicines for pulmonary fibrosis, and collaborators Drs. Martin Kolb and Kjetil Ask at McMaster University announced today additional measured advantages of inhaled GP-101 (aerosol pirfenidone) in the treatment of idiopathic pulmonary fibrosis (IPF).

21 Apr 2014

Researchers receive $3.7M NIH grant to develop anti-smoking program for HIV-infected smoker

Montefiore Medical Center researchers have received a $3.7 million grant from the National Institute on Drug Abuse at the National Institutes of Health (NIH) to develop an anti-smoking program for HIV-infected smokers.

21 Apr 2014

Researchers devise new approach to treatment of Alzheimer's disease

A team of researchers from Columbia University Medical Center, Weill Cornell Medical College, and Brandeis University has devised a wholly new approach to the treatment of Alzheimer's disease involving the so-called retromer protein complex. Retromer plays a vital role in neurons, steering amyloid precursor protein (APP) away from a region of the cell where APP is cleaved, creating the potentially toxic byproduct amyloid-beta, which is thought to contribute to the development of Alzheimer's.

21 Apr 2014

Survey finds counterfeit and defective emergency contraceptives in Peru

A survey of emergency contraceptive pills in Peru found that 28 percent of the batches studied were either of substandard quality or falsified. Many pills released the active ingredient too slowly. Others had the wrong active ingredient. One batch had no active ingredient at all.

20 Apr 2014

Sprifermin reduces cartilage loss in patients with knee osteoarthritis

In a new study in patients with osteoarthritis (OA) of the knee, at 12 months, total femorotibial cartilage thickness loss was reduced in sprifermin (recombinant human fibroblast growth factor 18)-treated knees compared to placebo-treated knees, with effects being significant in the lateral femorotibial compartment but not in the central femorotibial compartment.

18 Apr 2014

LSTM researchers to conduct extensive research on HIV and schistosomiasis coinfection in African children

Researchers from LSTM have called for more research to be carried out into HIV and schistosomiasis coinfection in children in sub-Saharan Africa.

18 Apr 2014

Probiotics usage proves ineffective for infant colic symptoms

Colic affects about one in five infants in the United States annually and accounts for numerous pediatric visits during the first several months after birth.

18 Apr 2014

Scientists develop microbicide gel that prevents transmission of multiple STIs in vagina/rectum in animals

Population Council scientists and their partners have found that their proprietary microbicide gel is safe, stable, and can prevent the transmission of multiple sexually transmitted infections (STIs) in both the vagina and rectum in animals: HIV, herpes simplex virus 2 (HSV-2), and human papillomavirus (HPV).

18 Apr 2014

Skin docs prescribe costlier drugs after free samples

In other news, panels recommend a costly hepatitis C drug for the sickest patients, and cancer doctors will compare the value of costly cancer drugs.

18 Apr 2014

OPKO Health enters into definitive agreement to acquire Inspiro Medical

OPKO Health, Inc. has entered into a definitive agreement to acquire Inspiro Medical Ltd., an Israeli medical device company developing a new platform to deliver small molecule drugs such as corticosteroids and beta agonists or larger molecules to treat respiratory diseases. Inspiro's Inspiromatic is a "smart" easy-to-use dry powder inhaler with several advantages over existing devices.

17 Apr 2014

Research on HIV and schistosomiasis coinfection in sub-Saharan Africa children

Paper shows that more work is needed to fully understand the consequences of coinfection. Researchers from LSTM have called for more research to be carried out into HIV and schistosomiasis coinfection in children in sub-Saharan Africa.

17 Apr 2014

Neurovive presents new breakthrough on energy regulation at cellular level

NeuroVive, a leading mitochondrial medicine company, is presenting a breakthrough in the company's work on energy regulation at the cellular level.

17 Apr 2014

Efficacy News and Research

Johns Hopkins scientists find a way to prevent atherosclerosis

NeuroPhage engineers series of molecules with potential to treat most neurodegenerative diseases

Pfizer reports positive results from two tofacitinib Phase 3 trials for moderate-to-severe plaque psoriasis

IMPAKT breast cancer conference abstracts online

Can-Fite BioPharma signs agreement with Smart Assays to develop A3AR predictive biomarker kit

Sarepta Therapeutics plans to submit eteplirsen NDA for treatment of Duchenne muscular dystrophy

FDA and EC grant Orphan Drug Designation to Boehringer’s volasertib for acute myeloid leukemia

IV-administered ketamine effective in patients with chronic PTSD

Genoa Pharmaceuticals, McMaster University report additional benefits of GP-101 for IPF patients

Researchers receive $3.7M NIH grant to develop anti-smoking program for HIV-infected smoker

Researchers devise new approach to treatment of Alzheimer's disease

Survey finds counterfeit and defective emergency contraceptives in Peru

Sprifermin reduces cartilage loss in patients with knee osteoarthritis

LSTM researchers to conduct extensive research on HIV and schistosomiasis coinfection in African children

Probiotics usage proves ineffective for infant colic symptoms

Scientists develop microbicide gel that prevents transmission of multiple STIs in vagina/rectum in animals

Skin docs prescribe costlier drugs after free samples

OPKO Health enters into definitive agreement to acquire Inspiro Medical

Research on HIV and schistosomiasis coinfection in sub-Saharan Africa children

Neurovive presents new breakthrough on energy regulation at cellular level

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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