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Sex-specific mitochondrial marker deficiencies linked to early cognitive dysfunction in Alzheimer’s disease

Research reveals sex-specific free-carnitine deficiency in women with cognitive impairment, linking mitochondrial metabolism to Alzheimer's disease progression.

10 Jan 2025

Mussel-inspired nanoparticles for targeted lung cancer therapy

Researchers from POSTECH and Kyungpook National University have developed a novel inhalable therapeutic delivery system for lung cancer, leveraging mucoadhesive protein nanoparticles inspired by the adhesive properties of marine mussels.

9 Jan 2025

World’s largest proteomics study launched by UK Biobank

UK Biobank has today announced the launch of the world's most comprehensive study of the proteins circulating in our bodies, which will transform the study of diseases and their treatments.

9 Jan 2025

Comorbid atopic diseases affect prognosis of alopecia areata

Asthma, atopic dermatitis or Hashimoto's thyroiditis as concomitant diseases are risk factors for clinical features associated with a poor prognosis in circular hair loss, also known as alopecia areata (AA).

9 Jan 2025

Groundbreaking G6PD diagnostic test prequalified by WHO to ensure safe malaria treatment

On 18 December 2024, the World Health Organization (WHO) prequalified the first diagnostic test for glucose-6-phosphate dehydrogenase (G6PD) deficiency which can help to safely deliver WHO-recommended treatments to prevent relapse of Plasmodium vivax (P. vivax) infection.

9 Jan 2025

Research from second pig heart transplant provides new directions for xenotransplantation

Continuing significant advancements in the field of xenotransplantation, surgeon-scientists from the University of Maryland School of Medicine provided an extensive analysis on the second patient in the world to receive a genetically-modified pig organ.

9 Jan 2025

Ingenza partners with HydRegen to advance sustainable biomanufacturing

Ingenza's collaboration with HydRegen focuses on optimizing enzyme expression, paving the way for greener, cost-effective manufacturing of amine chemicals.

From Ingenza Ltd 9 Jan 2025

New brain stem cell discovery could usher in better treatments for glioblastoma

The discovery of a new type of stem cell in the brain could usher in better treatments for the deadliest brain tumor.

8 Jan 2025

AI-designed drug shows promise for inflammatory bowel disease

Insilico Medicine ('Insilico'), a clinical-stage generative artificial intelligence (AI)-driven drug discovery and development company, today announces positive results from two Phase I studies in Australia and China of ISM5411, a novel gut-restricted and PHD specific Inhibitor designed and optimized with the support of Insilico's Chemistry42 commercially-available generative reinforcement learning platform, for Inflammatory Bowel Disease (IBD).

8 Jan 2025

Key actions identified to improve post-acute care for TBI patients

A new systematic literature search identified the highest priority clinical actions aimed at improving post-acute care for non-hospitalized traumatic brain injury (TBI). The study is published in the peer-reviewed Journal of Neurotrauma.

7 Jan 2025

AI-based method predicts progression of autoimmune diseases

Autoimmune diseases, where the immune system mistakenly attacks the body's own healthy cells and tissues, often have a preclinical stage before diagnosis that's characterized by mild symptoms or certain antibodies in the blood.

7 Jan 2025

Does smoking increase chronic kidney disease risk?

Researchers determine whether smoking increases the risk of chronic kidney disease.

7 Jan 2025

NIH funding supports research into chronic pain following surgery

After surgery, pain is expected and often subsides within a few weeks. But for around 20% of patients, persistent pain may continue for months or even years after a procedure, impacting quality of life and putting patients at risk for opioid overuse.

6 Jan 2025

Glucarpidase shows promise in treating kidney toxicity from methotrexate

An FDA-approved medication called glucarpidase could serve as an antidote to kidney toxicity in patients receiving the chemotherapy drug methotrexate (MTX), according to a new study by investigators at Mass General Brigham.

6 Jan 2025

New biomarkers may offer a more sensitive approach for monitoring kidney health

Drug-induced kidney injury, or nephrotoxicity, is a common complication in clinical medicine that happens when drugs damage the kidneys.

6 Jan 2025

Non-opioid pain relief proven more effective after wisdom teeth removal

A combination of acetaminophen (Tylenol) and ibuprofen (Advil, Motrin) controls pain after wisdom tooth removal better than opioids, according to a Rutgers Health study that could change how dentists treat post-surgical pain.

6 Jan 2025

Study reveals major differences between human and mouse PD-1 in cancer research

Since its discovery in the 1990s, "programmed cell death protein 1," or PD-1, has been regarded as a leading target in cancer treatments.

3 Jan 2025

Unveiling the role of gene inactivation in human disease

New work by Columbia researchers has turned a textbook principle of genetics on its head and revealed why some people who carry disease-causing genes experience no symptoms.

2 Jan 2025

Predicting H5N1 disease severity based on T cell responses

New research led by scientists at La Jolla Institute for Immunology (LJI) suggests that many people already have immune cells on "stand by" to fight the H5N1 virus, also known as highly pathogenic avian influenza.

2 Jan 2025

AI models struggle in real-world medical conversations

Artificial intelligence tools such as ChatGPT have been touted for their promise to alleviate clinician workload by triaging patients, taking medical histories and even providing preliminary diagnoses.

2 Jan 2025