Protein Folding News and Research

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Study: ANGEL2 enzyme performs unique chemical reaction at the end of RNA molecules

Scientists led by Javier Martinez from the Max Perutz Labs, a joint venture of the Medical University of Vienna and the University of Vienna, have identified a unique chemical reaction at the end of RNA molecules for the first time in human cells.

31 Jul 2020

Researchers stabilize the closed SARS-CoV-2 spike trimer

Now, a new study by researchers at Janssen Vaccines & Prevention BV and Leiden University and published on the preprint server bioRxiv uses cryoEM to reveal the structure of this trimer, in order to support both vaccine development and diagnostic testing based on antibody production.

14 Jul 2020

X-ray scattering technique reveals mechanisms of protein folding

KAIST researchers have used an X-ray method to track how proteins fold, which could improve computer simulations of this process, with implications for understanding diseases and improving drug discovery.

9 Jul 2020

New approach holds incredible potential for developing new therapeutics

Nearly every drug that is, or has ever been, used was derived from nature -- harnessing compounds created by organisms over eons to fight diseases. But decades ago, biochemists postulated that it might be possible to design a new drug from scratch by linking up amino acids in precise ways.

30 Jun 2020

Mutational targets of SARS-CoV-2 receptor-binding domain for vaccine-antiviral development

The COVID-19 pandemic has spread throughout the whole world within six months, causing millions of infections and hundreds of thousands of deaths. Yet there is no effective vaccine or antiviral to deal with it.

18 Jun 2020

Scientists discover unexpected role of heat shock proteins during neuronal differentiation

A research team led by Dr Chaogu Zheng from the School of Biological Sciences at the University of Hong Kong, in collaboration with a team led by Professor Martin Chalfie (2008 Nobel Laureate in Chemistry) from the Department of Biological Sciences at Columbia University, recently discovered an unexpected role of the heat shock proteins, also known as the molecular chaperones, during neuronal differentiation, which refers to the process a neuron takes to acquire its shape and function.

16 Jun 2020

Using nanotheranostics approach to treat cancer

The concept of theranostics revolves around the stratification of patients into specific groups based on their response to different treatments and their disease risks.

10 Jun 2020

A new therapeutic approach to improve the health of diabetic patients

Scientists at Sanford Burnham Prebys Medical Discovery Institute have mapped for the first time the vast network of proteins that interact with proinsulin, the protein the body normally processes into insulin.

27 May 2020

Researchers identify a natural amino acid as potential treatment for polyQ diseases

Familial spinocerebellar ataxia (SCA), Huntington disease, and spinal and bulbar muscular atrophy are inherited neurodegenerative diseases.

25 May 2020

Researchers discover hidden symmetry in chemical kinetic equations

Rice University researchers have discovered a hidden symmetry in the chemical kinetic equations scientists have long used to model and study many of the chemical processes essential for life.

4 May 2020

Temple researchers receive NIAID grant to study immunological synapse formation

Switching immune cells on is a critical step in combating infection. In the case of T cells, which are key players in immunity, this happens when dormant T cells circulating in the blood encounter a suspicious agent on the surface of specialized antigen-presenting cells.

14 Apr 2020

Russian Science Foundation funds eleven Kazan University projects

Eleven Kazan University projects receive funding from the Russian Science Foundation. The results were published on 1st April 2020.

2 Apr 2020

OXGENE and The Native Antigen Company Announce Collaboration to Increase COVID-19 Antigen Production for Diagnostic Kits and Vaccine Development

OXGENE™ and The Native Antigen Company today announced a collaboration to scale up production of SARS-CoV-2 (COVID-19) reagents.

2 Apr 2020

A simple, straightforward approach to protein modification

Proteins are essential parts of organisms; thus, they are widely used in medicine, biology and chemistry. Enhancing their inherent properties by adding functional molecules to their structures is a common and important step in many fields.

14 Feb 2020

Parkinson’s disease could be prevented by gut microbes

One common gut organism that helps us digest food better could also be a powerful instrument in preventing or reversing the symptoms of Parkinson’s disease (PD), according to a recent study. The changes are due to the ability of this bacterium to delay the build-up of a toxic protein involved in this in the disease condition, or even to eliminate the toxin altogether.

14 Jan 2020