Small Cell Lung Cancer News and Research

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Small cell lung cancer is a disease in which malignant (cancer) cells form in the tissues of the lung. Small cell lung cancer is an aggressive (fast-growing) cancer that can spread to other parts of the body. The cancer cells look small and oval-shaped when looked at under a microscope.

Stereotactic radiation shows promise for small cell lung cancer with brain metastases

A new study led by investigators from Mass General Brigham trialed stereotactic (targeted) brain-directed radiation in 100 patients with small cell lung cancer and brain metastases, finding they experienced positive outcomes that support use of targeted radiation in the future for such patients.

12 Jul 2025

Corticosteroids may reduce effectiveness of immunotherapy in lung cancer

Corticosteroids, a commonly prescribed medication to alleviate cancer-related symptoms for non-small cell lung cancer patients treated with immunotherapy, are the main reason certain immunotherapies may fail in treating the disease, according to new research by Keck Medicine of USC.

7 Jul 2025

Alzheimer’s protein found to drive lung cancer spread to the brain

Researchers at McMaster University, Cleveland Clinic and Case Comprehensive Cancer Center have uncovered how a protein long associated with Alzheimer's disease helps lung cancer spread to the brain – a discovery that offers hope that existing Alzheimer's drugs could be repurposed in preventing cancer's spread.

3 Jul 2025

Study maps HER2 mutations in lung cancer patients from Northeastern Brazil

A new research paper was published in Volume 16 of Oncotarget on June 17, 2025, titled "Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights."

27 Jun 2025

Insilico Medicine begins clinical trial for AI-designed cancer drug ISM3412

Insilico Medicine, a clinical-stage biotechnology company driven by generative artificial intelligence (AI), today announces that the first patient has been dosed in a global multicenter clinical trial (NCT06414460) to evaluate ISM3412, a potentially best-in-class, AI-empowered MAT2A inhibitor with novel structure, in patients with locally advanced and metastatic solid tumors.

27 Jun 2025

Fusion genes found to be pivotal players in cancer development

Fusion genes, arising from abnormal chromosomal rearrangements, are gaining recognition as pivotal players in cancer development. These genetic alterations result in the creation of hybrid genes with altered functions, often driving tumor progression.

25 Jun 2025

Bispecific antibodies offer new hope for resistant NSCLC patients

As the leading cause of cancer-related death, lung cancer remains a noteworthy hazard to human health. NSCLC is the most prevalent subtype, accounting for nearly 85% of all lung cancer cases.

23 Jun 2025

CHAF1B drives lung squamous cell carcinoma progression by repressing SETD7

CHAF1B, a histone chaperone component of the chromatin assembly factor-1 complex, is overexpressed in multiple cancers and linked to tumor progression, but its role in lung squamous-cell carcinoma (LUSC) remained unclear.

11 Jun 2025

Novel self-propelled ferroptosis nanoinducer achieves deeper penetration into tumor tissues

A novel self-propelled ferroptosis nanoinducer developed by Southern Medical University was able to achieve deeper penetration into tumor tissues to show enhanced anti-cancer effects, while remaining considerable biocompatibility.

10 Jun 2025

Study aims to demystify the immune toxicity triggered by osimertinib-ICI co-treatment

Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases and remains a leading cause of cancer mortality worldwide.

6 Jun 2025

SWOG S2302 Pragmatica-Lung study demonstrates value of streamlined clinical trials in real world settings

The SWOG S2302 Pragmatica-Lung trial, which broke new ground with its streamlined pragmatic design, unusually broad eligibility criteria, and reduced data collection, has quickly answered its primary question, finding that the investigational combination it tested did not significantly extend overall survival compared to standard of care treatments.

4 Jun 2025

Immunotherapy before surgery boosts long term survival in lung cancer, trial shows

Results from a phase 3 clinical trial published in the New England Journal of Medicine, today (June 2nd) show that patients with lung cancer who received an immunotherapy drug, nivolumab, along with standard chemotherapy before surgery had improved long term survival compared to those who received chemotherapy alone, at 5 years after completing treatment.

2 Jun 2025

TTF1 identified as key biomarker for advanced KRAS G12C-mutated non-small cell lung cancer

Researchers from The University of Texas MD Anderson Cancer Center have identified a new biomarker, TTF-1, that was predictive of survival outcomes for patients with advanced KRAS G12C-mutated non-small cell lung cancer (NSCLC), following treatment with the KRAS targeted therapy sotorasib.

30 May 2025

Mutation profiles and clinicopathological correlations in lung squamous cell carcinoma

Lung Squamous cell carcinoma (LSCC) represents the second most common non-small cell lung cancer.

26 May 2025

Immune checkpoint inhibitors linked to increased myocarditis risk in lung cancer patients

A new editorial was published in Volume 12 of Oncoscience on May 2, 2025, titled "Immune checkpoint inhibitors and myocarditis: Lessons from a nationwide cohort study."

16 May 2025

Targeted drug zongertinib shows strong results for HER2-mutant lung cancer in clinical trial

The HER2-targeted therapy zongertinib demonstrated clinical benefits for previously treated patients with advanced HER2-mutant non-small cell lung cancer – particularly those with specific HER2 mutations – with manageable side effects, according to results from the Phase Ia/Ib Beamion LUNG-1 trial led by researchers from The University of Texas MD Anderson Cancer Center.

28 Apr 2025

Small Cell Lung Cancer News and Research

Stereotactic radiation shows promise for small cell lung cancer with brain metastases

Corticosteroids may reduce effectiveness of immunotherapy in lung cancer

Alzheimer’s protein found to drive lung cancer spread to the brain

Study maps HER2 mutations in lung cancer patients from Northeastern Brazil

Insilico Medicine begins clinical trial for AI-designed cancer drug ISM3412

Fusion genes found to be pivotal players in cancer development

Bispecific antibodies offer new hope for resistant NSCLC patients

CHAF1B drives lung squamous cell carcinoma progression by repressing SETD7

Novel self-propelled ferroptosis nanoinducer achieves deeper penetration into tumor tissues

Study aims to demystify the immune toxicity triggered by osimertinib-ICI co-treatment

SWOG S2302 Pragmatica-Lung study demonstrates value of streamlined clinical trials in real world settings

Immunotherapy before surgery boosts long term survival in lung cancer, trial shows

TTF1 identified as key biomarker for advanced KRAS G12C-mutated non-small cell lung cancer

Mutation profiles and clinicopathological correlations in lung squamous cell carcinoma

Immune checkpoint inhibitors linked to increased myocarditis risk in lung cancer patients

Targeted drug zongertinib shows strong results for HER2-mutant lung cancer in clinical trial

Dana-Farber experts present innovative cancer studies at the 2025 AACR Annual Meeting

New method improves RMST analysis for clinical and epidemiological studies

The dual role of microRNAs in lung cancer progression and suppression

Some lung cancer patients maintain long-term control after stopping immunotherapy

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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