Tumor Necrosis Factor News and Research

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Muscle fat infiltration predicts heart disease risk better than BMI, study finds

Skeletal muscle fat infiltration (IMAT) is linked to coronary microvascular dysfunction and increased cardiovascular risk, independent of BMI and traditional risk factors.

21 Jan 2025

Key biomarkers linked to obesity-induced heart failure

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Many studies have reported that obesity causes heart failure (HF) pathogenesis.

17 Jan 2025

Qigong shows promise in reducing chronic back pain in veterans

Chronic pain is widespread in the United States, particularly among military veterans, affecting between 40 to 70% of this population and serving as a leading cause of disability.

17 Jan 2025

Inflammasome proteins found to prevent cancer by regulating stem cells

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, according to a preclinical study by Weill Cornell Medicine investigators.

17 Jan 2025

Inflammasome protects stem cells from becoming cancerous

13 Jan 2025

Study finds certain H5N1 strains in cattle linked to milder human illness; other variants remain a concern

Study reveals that contemporary HPAI H5N1 viruses show reduced replication and immune activation in human lung organoids, potentially explaining milder disease in humans compared to historic strains.

13 Jan 2025

Single-dose malaria vaccine offers unprecedented 90% protection

Results from the malaria vaccine trial indicate that GA2 immunization provides significant protection, paving the way for more effective vaccination strategies.

8 Jan 2025

Anti-TNF drugs proven to prevent perianal fistulas in Crohn's Disease

Early treatment of pediatric Crohn's disease with anti-tumor necrosis factor medications can substantially reduce the risk of perianal fistulas, a particularly debilitating complication of Crohn's disease.

23 Dec 2024

Annona squamosa extracts show promise in treating pain and arthritis

In Brazil, researchers have identified substances with analgesic, anti-inflammatory, anti-hyperalgesic (against persistent pain) and anti-arthritic activity in the leaves of Annona squamosa, a tree popularly known in the country as fruta-do-conde or pinha.

20 Dec 2024

Mouse study links glyphosate to Alzheimer's-like brain changes and anxiety

Glyphosate exposure in mice exacerbates Alzheimer's-like neuropathologies, increases neuroinflammation, and leaves lasting effects, even after prolonged recovery.

9 Dec 2024

Filgotinib offers new promise for managing Crohn’s disease

Filgotinib, a JAK1 preferential inhibitor, shows promise as an effective and well-tolerated maintenance therapy for Crohn's disease, achieving clinical and endoscopic remission in phase 3 trials. The findings highlight its potential as a novel therapeutic option for difficult-to-treat patients.

8 Dec 2024

Extracellular vesicle DNA regulates immune responses and suppresses liver metastasis

The study highlights how EV-DNA packaging influences immune responses and its promise as a biomarker for assessing colorectal cancer metastasis risk.

6 Dec 2024

Exploring the potential of MSCs in cancer therapy

A new review was published in Oncotarget's Volume 15 on November 22, 2024, entitled "Mesenchymal stem cells – the secret agents of cancer immunotherapy: Promises, challenges, and surprising twists."

4 Dec 2024

How carrageenan affects insulin resistance

A randomized controlled trial found that carrageenan, a common food additive, may cause subclinical inflammation and insulin resistance in overweight individuals, mediated by gut permeability and inflammation. Effects were linked to BMI but not observed in non-overweight participants during short-term exposure.

3 Dec 2024

Understanding the pathophysiological relationship between OSA and metabolic syndrome

Cardiovascular diseases remain a leading cause of mortality globally, particularly among individuals with both obstructive sleep apnea (OSA) and metabolic syndrome (MetS).

27 Nov 2024

Late-liver-stage malaria vaccine delivers 89% protection and boosts cellular immunity

Genetically attenuated malaria parasites with extended liver-stage arrest (GA2) showed 89% protection in a clinical trial, surpassing earlier vaccine candidates and highlighting the potential of cellular immunity.

26 Nov 2024

Atlas maps plasma proteins to transform disease diagnosis and treatment

Researchers have developed the most comprehensive atlas linking plasma proteins to diseases and traits in over 53,000 individuals, offering groundbreaking insights for precision medicine. This resource uncovers 168,100 protein-disease associations and identifies new therapeutic targets.

25 Nov 2024