Molecule News and Research

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Vaccine candidate? Researchers synthesize oligosaccharide from anthrax pathogen

For weeks a white powder caused fear and shock for the American population: a few days after the attacks on September 11th, 2001, four innocent people became the victims of letters that contained the powder - spores of the anthrax pathogen. German researchers have now synthesized a molecule characteristic of anthrax in the laboratory which may be the basis for a new anthrax vaccine.

26 Sep 2005

Aquaporin-4 is the first specific molecule to be defined as a target for the autoimmune response in any form of MS

Researchers have identified a molecular suspect in a disorder similar to multiple sclerosis (MS) that attacks the optic nerve and spinal cord, according to a report presented at the 130th annual meeting of the American Neurological Association in San Diego. The protein, called aquaporin-4, is a channel protein that allows water to move in and out of cells.

26 Sep 2005

Scientists eventually may be able to determine the structure of proteins from their genomic sequences

Computers can predict the detailed structure of small proteins nearly as well as experimental methods, at least some of the time, according to new studies by Howard Hughes Medical Institute researchers.

26 Sep 2005

Possible molecular origin of at least nine human diseases of nervous system degeneration

These neurodegenerative diseases, including Huntington's disease, share an abnormal deposit of proteins inside nerve cells. This deposition of protein results from a kind of genetic stutter within the cell's nucleus asking for multiple copies of the amino acid glutamine, a building block of protein structure.

26 Sep 2005

Raf Kinase Inhibitor Protein plays a role in controlling the active movement of cells

University of Illinois at Chicago researchers report that a protein that regulates key signaling pathways in cells also plays a role in controlling the active movement or migration of cells. The finding may suggest new pharmaceutical therapies for treating a variety of diseases, including cancer.

26 Sep 2005

Prediction of new polymorph of the Alzheimer's drug, piracetam

A challenge, presented at last year's e-Science All Hands meeting, has resulted in an e-Science project achieving one of the holy grails of the pharmaceutical industry - the computational prediction of a previously unidentified crystal structure, or polymorph, of a drug molecule.

22 Sep 2005

Snail, a molecule normally important in embryonic development, can promote breast cancer recurrence

Using a recently developed mouse model of breast cancer, a team from the University of Pennsylvania School of Medicine has shown that Snail, a molecule normally important in embryonic development, can promote breast cancer recurrence.

20 Sep 2005

Salicylate an active metabolite of aspirin - weakens lipid membranes

It's well known that high doses of aspirin can cause ulcers and temporary deafness, but the biochemical mechanism responsible for these phenomena has never been deciphered.

19 Sep 2005

Possible new target for treating obesity and diabetes

The new target, a molecule called hVps34, is activated by amino acids (nutrients) entering the cell. This molecule triggers the activation of an enzyme, S6 Kinase 1 (S6K1), whose function UC researchers linked last year to obesity and insulin resistance.

19 Sep 2005

Carbon nanotubes as transport agents for antimycotics (antifungal agents)

Putting pharmaceutical agents into the body isn't hard, but getting them into targeted areas can be problematic. If drugs aren't taken up by a large enough proportion of cells, a suitable "transport agent" must be used.

19 Sep 2005

Human fat cells produce a protein that is linked to both inflammation and an increased risk of heart disease and stroke

Researchers at The University of Texas M. D. Anderson Cancer Center and The University of Texas Health Science Center at Houston have found that human fat cells produce a protein that is linked to both inflammation and an increased risk of heart disease and stroke.

19 Sep 2005

Tarceva should be tested as front-line therapy for older lung cancer patients

The tyrosine kinase inhibitor erlotinib (Tarceva) showed encouraging activity with relatively tolerable side effects in elderly, previously untreated patients with advanced non-small cell lung cancer (NSCLC), reports a team led by investigators from Dana-Farber Cancer Institute in Boston.

19 Sep 2005

Drug AMD-3100 may help cancer patients who need stem cell transplants

A new drug may help cancer patients mobilize the cells necessary to restore their blood-forming system after high-dose chemotherapy, according to results from a clinical trial at the Kimmel Cancer Center at Thomas Jefferson University Hospital in Philadelphia and at other centers across the nation.

19 Sep 2005

Researchers selectively knock out memory associations connected with receiving cocaine

Addicts crave drugs and suffer relapse not just because of the alluring high of drugs, but also because they are compelled by the powerful, haunting memory associations with the environment surrounding their drug taking. Thus, treatments that could eliminate those memory associations could prove effective in treating addiction, researchers believe.

19 Sep 2005

Generex Biotechnology granted Canadian patent

Generex Biotechnology Corporation has announced that it has been granted a patent by the Canadian Intellectual Property Office titled "Mixed Micellar Delivery System and Method of Preparation."

12 Sep 2005

Nuclear receptor proteins could change anti-inflammatory treatments

Several nuclear receptor proteins appear to overlap in their ability to exert anti-inflammatory effects, according to new research by scientists at the University of California, San Diego (UCSD).

12 Sep 2005

Scientists characterize the most infectious prion protein particles

A new study of prions - apparently malformed proteins that initiate deadly brain diseases such as Creutzfeldt-Jakob disease in humans - has yielded surprising information about how the size of prions relates to their infectivity.

10 Sep 2005

Nitric oxide could one day help women in their 30s and 40s remain fertile longer

Researchers have found that an important chemical compound, nitric oxide, appears to slow or reverse the aging of eggs in mouse ovaries. The finding suggests nitric oxide could one day help women in their 30s and 40s remain fertile longer and increase their chances of having healthy babies, the scientists say.

7 Sep 2005

Anorexia may be caused by change in brain chemical

A new study has found that women who have had a certain type of anorexia nervosa show a change in the activity of a chemical in their brain that is widely associated with anxiety and other affective disorders, for as long as one year after recovery.

7 Sep 2005

Anorexia nervosa linked with alteration of the activity of serotonin in their brain

Women who have had a certain type of anorexia nervosa show an alteration of the activity of a chemical in their brain that is widely associated with anxiety and other affective disorders more than one year after recovery, according to a study in the September issue of Archives of General Psychiatry.

6 Sep 2005

Molecule News and Research

Vaccine candidate? Researchers synthesize oligosaccharide from anthrax pathogen

Aquaporin-4 is the first specific molecule to be defined as a target for the autoimmune response in any form of MS

Scientists eventually may be able to determine the structure of proteins from their genomic sequences

Possible molecular origin of at least nine human diseases of nervous system degeneration

Raf Kinase Inhibitor Protein plays a role in controlling the active movement of cells

Prediction of new polymorph of the Alzheimer's drug, piracetam

Snail, a molecule normally important in embryonic development, can promote breast cancer recurrence

Salicylate an active metabolite of aspirin - weakens lipid membranes

Possible new target for treating obesity and diabetes

Carbon nanotubes as transport agents for antimycotics (antifungal agents)

Human fat cells produce a protein that is linked to both inflammation and an increased risk of heart disease and stroke

Tarceva should be tested as front-line therapy for older lung cancer patients

Drug AMD-3100 may help cancer patients who need stem cell transplants

Researchers selectively knock out memory associations connected with receiving cocaine

Generex Biotechnology granted Canadian patent

Nuclear receptor proteins could change anti-inflammatory treatments

Scientists characterize the most infectious prion protein particles

Nitric oxide could one day help women in their 30s and 40s remain fertile longer

Anorexia may be caused by change in brain chemical

Anorexia nervosa linked with alteration of the activity of serotonin in their brain

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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