Macrophage News and Research

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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

ABIVAX reports preclinical data on first-in-class drug candidate for functional cure of HIV/AIDS patients

ABIVAX an innovative biotechnology company targeting the immune system to eliminate viral disease, announced today that the Company presented new preclinical data on ABX464, ABIVAX's first-in-class drug candidate for a functional cure of patients with HIV/AIDS, during this week's HIV DART scientific conference in Los Cabos, Mexico.

9 Dec 2016

Researchers create 2-for-1 vaccine that protects mice from MERS and rabies

In a new study, researchers have modified a rabies virus, so that it has a protein from the MERS virus; this altered virus works as a 2-for-1 vaccine that protects mice against both Middle East Respiratory Syndrome (MERS) and rabies.

7 Dec 2016

Research unlocks potential new therapies for inflammatory diseases

Macrophages are frontline cells in our immune system. They detect microbial invaders and also tissue injury and then mount an appropriate response needed to clear the infection and repair the damaged tissue.

5 Dec 2016

Reseachers identify cellular ‘off’ switch for inflammatory immune response in asthma attacks

Working with human immune cells in the laboratory, Johns Hopkins researchers report they have identified a critical cellular "off" switch for the inflammatory immune response that contributes to lung-constricting asthma attacks.

2 Dec 2016

Low-dose chemotherapy regimens may be more effective at treating certain breast and pancreatic cancer types

Conventional, high-dose chemotherapy treatments can cause the fibroblast cells surrounding tumors to secrete proteins that promote the tumors' recurrence in more aggressive forms, researchers at Taipei Medical University and the National Institute of Cancer Research in Taiwan and University of California, San Francisco, have discovered.

24 Nov 2016

Study uncovers mechanism that causes chemo resistance of pancreatic cancer cells

A pioneering University of Liverpool research team have published a study that identifies the mechanism in the human body that causes resistance of pancreatic cancer cells to chemotherapy.

21 Nov 2016

Würzburg researchers develop novel technique to provide new insight into Salmonella infection process

Technological advances are making the analysis of single bacterial infected human cells feasible, Würzburg researchers have used this technology to provide new insight into the Salmonella infection process.

18 Nov 2016

New research shows immune paralysis in sepsis patients can be reversed

Failure of the immune system during blood poisoning (sepsis) can be reversed by a specific sugar.

18 Nov 2016

Getting drugs to bugs in NTM lung infections: an interview with Dr Jakko van Ingen

The first thing that is important to stress is that this is an area that we actually know very little about. What we generally think, rather than know, is that NTM has a lot in common with pulmonary tuberculosis.

17 Nov 2016

UAB researchers show how aging and excess dietary fat lead to heart failure

In mouse experiments, University of Alabama at Birmingham researchers have shown how aging and excess dietary fat create signals that lead to heart failure after a heart attack.

17 Nov 2016

Research shows CRAC channel inhibitors decrease lesion size, brain hemorrhage, and neurological deficits in TBI model

Researchers from the San Francisco Veterans Affairs Medical Center and UCSF, and CalciMedica, Inc., are presenting a poster at the 46th annual Society for Neuroscience meeting in San Diego describing the use of calcium release-activated calcium (CRAC) channel inhibitors in traumatic brain injury (TBI).

16 Nov 2016

TSRI study suggests new approach to limit tumor growth by targeting immune system cells

A new study led by scientists at The Scripps Research Institute suggests there may be a way to limit tumor growth by targeting immune system cells called macrophages.

11 Nov 2016

Immune checkpoint cancer therapies may cause rare cardiac side effects linked to unexpected immune response

Combination therapy utilizing two approved immunotherapy drugs for cancer treatment may cause rare and sometimes fatal cardiac side effects linked to an unexpected immune response.

4 Nov 2016

TPU scientists developing bioactive coating for medical implants

A group of young scientists from Tomsk Polytechnic University are developing a bioactive coating for medical implants. Due to its properties, it will be able to "convince" the body not to reject the artificial bones and joints.

2 Nov 2016

Researchers identify possible trigger of chronic inflammation in people with diabetes

Inflammation is one of the main reasons why people with diabetes experience heart attacks, strokes, kidney problems and other, related complications. Now, in a surprise finding, researchers at Washington University School of Medicine in St. Louis have identified a possible trigger of chronic inflammation.

2 Nov 2016

Research shows way to directly target genes within specific cell type

The cornerstone of genetics is the loss-of-function experiment. In short, this means that to figure out what exactly gene X is doing in a tissue of interest—be it developing brain cells or a pancreatic tumor—you somehow cut out, switch off or otherwise destroy gene X in that tissue and then watch what happens.

1 Nov 2016

Researchers identify two new potential drug targets for treating atherosclerosis

Researchers at Brigham and Women's Hospital have found two new potential drug targets for treating arterial diseases such as atherosclerosis.

31 Oct 2016

New biological mechanism generates cells to fight against Candida albicans infections, find researchers

Researchers from the Universitat de València and the Cedar Sinai Medical Center in Los Angeles have partnered to describe a biological mechanism that generates cells which are better equipped to fight off serious infections caused by the Candida albicansfungus.

26 Oct 2016

New approach could overcome large immunosuppressive tumors

Harnessing the body's own immune system to destroy tumors is a tantalizing prospect that has yet to realize its full potential. However, a new advance from MIT may bring this strategy, known as cancer immunotherapy, closer to becoming reality.

24 Oct 2016

UCSF researchers find active HIV in tissue samples of patients treated with antiretrovirals

While successful treatment of HIV with antiretroviral medications leads to undetectable levels of virus in the blood, controls the disease and leads to much longer lifespans, scientists know that HIV continues to reside in tissues.

21 Oct 2016

Macrophage News and Research

Further Reading

ABIVAX reports preclinical data on first-in-class drug candidate for functional cure of HIV/AIDS patients

Researchers create 2-for-1 vaccine that protects mice from MERS and rabies

Research unlocks potential new therapies for inflammatory diseases

Reseachers identify cellular ‘off’ switch for inflammatory immune response in asthma attacks

Low-dose chemotherapy regimens may be more effective at treating certain breast and pancreatic cancer types

Study uncovers mechanism that causes chemo resistance of pancreatic cancer cells

Würzburg researchers develop novel technique to provide new insight into Salmonella infection process

New research shows immune paralysis in sepsis patients can be reversed

Getting drugs to bugs in NTM lung infections: an interview with Dr Jakko van Ingen

UAB researchers show how aging and excess dietary fat lead to heart failure

Research shows CRAC channel inhibitors decrease lesion size, brain hemorrhage, and neurological deficits in TBI model

TSRI study suggests new approach to limit tumor growth by targeting immune system cells

Immune checkpoint cancer therapies may cause rare cardiac side effects linked to unexpected immune response

TPU scientists developing bioactive coating for medical implants

Researchers identify possible trigger of chronic inflammation in people with diabetes

Research shows way to directly target genes within specific cell type

Researchers identify two new potential drug targets for treating atherosclerosis

New biological mechanism generates cells to fight against Candida albicans infections, find researchers

New approach could overcome large immunosuppressive tumors

UCSF researchers find active HIV in tissue samples of patients treated with antiretrovirals

Microbiology eBook

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Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

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Advancing degrader and proximity-based drug development

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Expanding access to NMR with the Fourier 80 Duo