Genetic News and Research

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Restoring brain energy balance reverses Alzheimer’s disease in mouse models

For over a century, Alzheimer's disease (AD) has been considered irreversible. Consequently, research has focused on disease prevention or slowing, rather than recovery.

23 Dec 2025

Discovery of fat-regulating enzyme points to a new obesity therapy

Obesity is a global epidemic and a major cause of morbidity and mortality because it increases the risk for comorbidities, including heart disease and fatty liver disease (MASLD).

23 Dec 2025

Study validates OVCAR3 as a model for high-grade serous ovarian cancer

A new research paper was published in Volume 12 of Oncoscience on October 14, 2025, titled "Bridging clinical insight and laboratory model in high-grade serous ovarian carcinoma (HGSOC) using DNA sequencing-based profiling of TP53."

23 Dec 2025

Antimicrobial resistance emerges as a slow-moving global pandemic

Once a medical miracle, antibiotics are now losing their power. Across the world, common infections are becoming harder-and sometimes impossible-to treat.

23 Dec 2025

High-fat cheese and cream consumption links to lower dementia risk over 25 years

Higher intake of high-fat cheese and cream was associated with a lower risk of all-cause dementia over 25 years in a large Swedish cohort, while low-fat dairy showed no association. Associations were strongest for vascular dementia and among APOE ε4 non-carriers, with findings remaining observational.

23 Dec 2025

Researchers create the most detailed 3D maps of the human genome

In a landmark effort to understand how the physical structure of our DNA influences human biology, Northwestern investigators and the 4D Nucleome Project have unveiled the most detailed maps to date of the genome's three‑dimensional organization across time and space, according to a new study published in Nature.

22 Dec 2025

Reframing the role of MCL1 in cancer signaling and metabolism

A study by the Mildred Scheel Early Career Center group led by Dr. Mohamed Elgendy at the TUD Faculty of Medicine provides fundamental insights into cancer biology.

22 Dec 2025

A senescence-based therapeutic approach for temporal lobe epilepsy

Temporal lobe epilepsy, which results in recurring seizures and cognitive dysfunction, is associated with premature aging of brain cells.

22 Dec 2025

Nascent polypeptide-associated complex regulates early stages of protein formation

To ensure that protein production in our cells runs smoothly, the protein complex NAC slows down the rate of protein synthesis right at the start.

22 Dec 2025

Precision immunotherapy for TRBC2-positive T-cell malignancies

Researchers at the Johns Hopkins Kimmel Cancer Center's Ludwig Center developed a new treatment that selectively targets TRBC2-positive T-cell cancers, expanding a precision approach they established in 2024 for TRBC1-positive tumors.

22 Dec 2025

Rethinking Mendelian assumptions in inherited retinal degenerations

A new study challenges what's long been assumed about genetic variants thought to always cause inherited blindness.

22 Dec 2025

Remodeling the tumor microenvironment to unlock CAR-T cell potential

Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized hematologic cancer treatment, but its efficacy in solid tumors remains limited by poor infiltration into the complex tumor microenvironment (TME).

22 Dec 2025

Homer1 gene plays a critical role in shaping attention

Attention disorders such as ADHD involve a breakdown in our ability to separate signal from noise. The brain is constantly bombarded with information, and focus depends on its ability to filter out distractions and detect what matters.

22 Dec 2025

Splicing regulator U2AF1 promotes angiogenesis in cardiac injury

A study published in Engineering shows that a protein called U2 small nuclear RNA auxiliary factor 1 (U2AF1), released by immune cells known as macrophages, helps grow new blood vessels in the heart after a myocardial infarction (MI) by altering how the gene Yap1 is spliced.

22 Dec 2025

Study charts the escalating spread of resistant bacteria and fungi

The success of modern medicine rests on the ability to control infections. But decades of antibiotic overuse—in hospitals, communities, and farms—have fueled a global surge in resistant microbes.

22 Dec 2025

Wasatch Biolabs announces co-marketing agreement with Agilent to advance native-read targeted sequencing

Wasatch BioLabs (WBL), a leader in native, long-read sequencing and epigenomic analysis, today announced a co-marketing agreement with Agilent Technologies to support the adoption of its Direct Targeted Methylation Sequencing (dTMS) platform.

From Wasatch BioLabs 22 Dec 2025

Simple blood test maps hidden Alzheimer’s disease changes

This population-based study used plasma pTau217 to estimate how common Alzheimer’s disease neuropathological changes are across age and cognitive status in a Norwegian community cohort. Prevalence rose steeply with age and was strongly associated with APOE ε4 genotype, education level, and kidney function, with implications for future use of blood biomarkers in clinical practice.

21 Dec 2025

Genes influence the gut microbiome beyond the individual

The gut microbiome - made up of trillions of microbes in the digestive tract - is vital for digestion and overall health. Diet and medication shape these microbial ecosystems, but the contribution of genetics has been more difficult to ascertain.

19 Dec 2025

New open-source tool maps gene regulation networks in cancer

University of Navarra (Spain) researchers have developed RNACOREX, a new open-source software capable of identifying gene regulation networks with applications in cancer survival analysis.

19 Dec 2025

New AI model brings precision medicine to multiple myeloma care

C. Ola Landgren, M.D., Ph.D., received HealthTree Foundation's prestigious 2025 Innovation Award for his work in developing CORAL, a new research tool that leverages AI to predict individual outcomes and guide treatment decisions in patients with multiple myeloma.

19 Dec 2025