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New CRISPR-based gene-editing tool could lead to better treatments for genetic disorders

A new CRISPR-based gene-editing tool has been developed which could lead to better treatments for patients with genetic disorders.

29 Sep 2023

New protein identified as substrate for histidine methylation

Proteins are subject to post-translational chemical modifications that result in functional diversity. Methylation is one such modification that is generally believed to occur on lysine and arginine residues.

29 Sep 2023

What are the pharmacological properties of black goji berries?

The pharmacological effects of the components of Lycium ruthenicum Murray fruits.

29 Sep 2023

Aerosolized ACE2 neutralizes COVID-19 variants in lab and mice tests

Researchers from the University of Texas Southwestern have developed an aerosolized, mutated form of ACE2 that effectively neutralizes various SARS-CoV-2 variants in both cell cultures and mice. The study suggests that this modified ACE2 has promising preventive and therapeutic potential against COVID-19, especially with its easy aerosolized administration.

28 Sep 2023

Small and precise CRISPR-Cas13bt3 system can be used to shred viruses

Small and precise: These are the ideal characteristics for CRISPR systems, the Nobel-prize winning technology used to edit nucleic acids like RNA and DNA.

27 Sep 2023

New technology could pave the way to rapid infection testing

New technology could pave the way to a future of rapid testing in hospitals and at home for both covid and urinary tract infection.

27 Sep 2023

Zoonotic spillover safeguarding: computationally designed antigen targets range of coronaviruses

Researchers used an interdisciplinary approach incorporating phylogenetics, 3D protein modeling, and plasmid design to identify and computationally design an antigen representing the core of most currently known sarbecoviruses.

27 Sep 2023

How do micronutrients influence neurological disorders?

The knowledge about micronutrients with regard to selected neurological diseases.

27 Sep 2023

Keck School of Medicine of USC to focus on Hispanic patients with NAFLD in multi-omics study

The Keck School of Medicine of USC has received funding from the National Institutes of Health as part of a five-year, $50.3 million "multi-omics" study of human health and disease involving six sites.

26 Sep 2023

Gene-silencer study could pave the way for novel cancer therapeutics

Deep inside our cells - each one complete with an identical set of genes - a molecular machine known as PRC2 plays a critical role in determining which cells become heart cells, versus brain or muscle or skin cells.

26 Sep 2023

Monkeypox mimics smallpox vaccine's immune response, new study reveals

The study in Nature Communications reveals that MPOX infection triggers an anti-viral antibody response akin to that from smallpox vaccination. Utilizing a comprehensive array of ELISAs, scientists found a high level of specificity and sensitivity in detecting antibodies against both MPOX and smallpox, offering a new, accurate way to measure immune responses.

26 Sep 2023

Intranasal vaccine shows promise against COVID variants in hamsters

Intranasal mRNA-LNP vaccines show promise in Syrian golden hamsters, effectively reducing SARS-CoV-2 viral loads and lung pathology. The study suggests potential efficacy against new variants, setting the stage for future research in human applications.

25 Sep 2023

Could CaMKK2 enzyme be the key to treating bipolar disorder?

Researchers explore the role of the CaMKK2 signaling pathway in bipolar disorder, suggesting it as a new treatment target. By targeting this enzyme, scientists aim to develop more effective therapies for bipolar symptoms and metabolic dysfunction.

24 Sep 2023

Machine learning speeds up virtual drug screening by 10-fold

Boosting virtual screening with machine learning allowed for a 10-fold time reduction in the processing of 1.56 billion drug-like molecules. Researchers from the University of Eastern Finland teamed up with industry and supercomputers to carry out one of the world's largest virtual drug screens.

22 Sep 2023

New anticancer treatment technology targets cancer cell lysosomes and overcomes drug resistance

A groundbreaking anticancer treatment technology that selectively targets cancer cell lysosomes and overcomes drug resistance has been developed by Professor Ja-Hyoung Ryu and his research team in the Department of Chemistry at UNIST.

22 Sep 2023

Weill Cornell Medicine receives NIH grant to lead a national contraceptive research center

Weill Cornell Medicine has received a three-year, nearly $6 million grant to lead one of three national contraceptive research centers.

21 Sep 2023

Rice engineers develop split gene-editing tool with enhanced control

To make a gene-editing tool more precise and easier to control, Rice University engineers split it into two pieces that only come back together when a third small molecule is added.

21 Sep 2023

Could a genetic biomarker predict your risk for severe food allergies?

Researchers at Ann & Robert H. Lurie Children's Hospital of Chicago have identified a genetic biomarker, α-tryptase, that may predict the severity of food allergy reactions. This discovery opens the door for new treatment strategies and offers a way to distinguish patients at risk for severe reactions.

21 Sep 2023

Is sucralose the safer sweetener for your gut health?

The study found that consuming a beverage sweetened with sucrose significantly increased bacterial endotoxin levels in the blood, a marker for inflammation and gut barrier dysfunction, while no such effect was observed with sucralose-sweetened drinks. The findings suggest that sucralose may be a safer alternative to sucrose in terms of intestinal health and inflammation.

19 Sep 2023

Researchers identify a rare cause of male infertility and discover a potential cure

Researchers investigated the genetic underpinning of asthenozoospermia, the leading cause of male fertility.

18 Sep 2023

Enzyme News and Research

New CRISPR-based gene-editing tool could lead to better treatments for genetic disorders

New protein identified as substrate for histidine methylation

What are the pharmacological properties of black goji berries?

Aerosolized ACE2 neutralizes COVID-19 variants in lab and mice tests

Small and precise CRISPR-Cas13bt3 system can be used to shred viruses

New technology could pave the way to rapid infection testing

Zoonotic spillover safeguarding: computationally designed antigen targets range of coronaviruses

How do micronutrients influence neurological disorders?

Keck School of Medicine of USC to focus on Hispanic patients with NAFLD in multi-omics study

Gene-silencer study could pave the way for novel cancer therapeutics

Monkeypox mimics smallpox vaccine's immune response, new study reveals

Intranasal vaccine shows promise against COVID variants in hamsters

Could CaMKK2 enzyme be the key to treating bipolar disorder?

Machine learning speeds up virtual drug screening by 10-fold

New anticancer treatment technology targets cancer cell lysosomes and overcomes drug resistance

Weill Cornell Medicine receives NIH grant to lead a national contraceptive research center

Rice engineers develop split gene-editing tool with enhanced control

Could a genetic biomarker predict your risk for severe food allergies?

Is sucralose the safer sweetener for your gut health?

Researchers identify a rare cause of male infertility and discover a potential cure

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