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New peptide triggers domino effect to suppress bladder cancer

Recently, a research team led by Professors Dahong Zhang and Qi Zhang from the Urology Department and the Institute of Urology at Zhejiang Provincial People's Hospital and the Translational Medicine Center discovered that a bladder tumor-targeting polyarginine peptide, R11, can directly bind to actin, destabilize the G-actin tetramer, and trigger the cascade breakdown of the actin-plectin-vimentin/ITGβ4 axis (referred to as the "cytoskeletal domino effect").

25 May 2026

RNA regulator RBM15 linked to immunity, metabolism, and cancer progression

A newly published review article brings attention to the expanding role of RBM15, a critical regulator of RNA m6A methylation, in the development and progression of a wide range of diseases, including cancer, metabolic disorders, and cardiovascular conditions.

24 May 2026

RNA regulator YTHDF2 plays key role in controlling inflammation

A new review highlights the emerging importance of YTHDF2, a key regulator of RNA activity, in shaping the body's inflammatory responses and influencing a wide range of diseases.

24 May 2026

Gum disease pathogen may drive Alzheimer’s through microglial ferroptosis pathway

Alzheimer's disease (AD), the leading cause of dementia, is projected to affect 152 million individuals worldwide by 2050; yet its pathogenesis remains poorly understood and effective treatments are lacking.

24 May 2026

AI-engineered p53 superproteins may reshape future cancer therapies

The Oncodarwinian Hypothesis (OdH) proposes a paradigm shift: cancer is not merely a disease but a potential macro‑immunoadaptive response – a self‑replicating algorithm that can be reprogrammed via AI‑based 3D printed p53 superproteins.

22 May 2026

Gene-based therapies could transform future pancreatitis treatment

Pancreatitis is a complex inflammatory disease driven by both genetic and environmental factors. It poses substantial clinical challenges due to a lack of disease-modifying therapies.

22 May 2026

Scientists map genetic variants behind prostate cancer therapy failure

Recently, the research group led by Dr. Dechao Feng, Lecturer at University College London (UCL) and Distinguished Research Fellow at Zhejiang Provincial People's Hospital, published a review entitled "Intratumoral Androgens and Genetic Variants Driving Therapy Resistance in Prostate Cancer".

22 May 2026

Optimized extended PCLS culture system extends tissue viability up to two weeks

Precision-cut liver slice (PCLS) technology has long been regarded as a promising ex vivo platform because it preserves the native multicellular architecture of liver tissue.

22 May 2026

Explainable AI could make breast cancer drug predictions safer and clearer

AI-driven genomic analysis could help researchers identify existing drugs that may be repurposed for subtype-specific breast cancer treatment. The review proposes an interpretability-driven framework that links multi-omics data, mechanistic validation, and clinical translation to make AI predictions more transparent and clinically useful.

22 May 2026

Study supports routine childhood screening for type 1 diabetes

For ten years, the Fr1da study, coordinated by Helmholtz Munich, has been investigating whether early stages of type 1 diabetes in children can be detected in routine pediatric care.

21 May 2026

Machine learning lifestyle coaching helps reduce major depressive symptoms

More than 21% of U.S. adults experience depression, greatly impacting their quality of life. Many people with mild‑to‑moderate depression can improve their symptoms by adjusting daily habits like sleep, exercise, diet and social interaction, according to Jyoti Mishra, PhD, associate professor of psychiatry at University of California San Diego School of Medicine.

21 May 2026

Polymer-based immunotherapies enhance tumor targeting and immune activation

Conventional immune checkpoint inhibitors, such as anti-PD-1/PD-L1 and anti-CTLA-4 antibodies, can reinvigorate T cells but typically benefit less than 30% of patients.

21 May 2026

Scientists link schizophrenia risk gene to early cortical neuron changes

Researchers at King's College London have identified the biological nature and timing of changes in human cortical neurons caused by altering activity of a schizophrenia-associated gene in developing human neurons.

20 May 2026

New AI framework maps systemic obesity damage at cellular resolution

Researchers at Helmholtz Munich, the Ludwig Maximilians University Munich (LMU) and collaborating institutions have developed an artificial intelligence (AI) framework that maps disease-related changes throughout the entire mouse body at cellular resolution.

20 May 2026

Plant-based eye drops harness photosynthesis to heal dry eyes

What if your eyes could use light to heal themselves? Drawing inspiration from how plants harness sunlight, researchers at the National University of Singapore (NUS) are pioneering a revolutionary treatment for dry eye disease.

20 May 2026

Engineered nanomaterials optimize delivery barriers in cancer immunotherapy

Cancer immunotherapy works by mobilizing the body's own immune system to recognize and destroy malignant cells.

20 May 2026

Spatial modeling of tissue compartments predicts breast cancer treatment response

HER2-positive breast cancer accounts for about 20% of breast cancer cases and is generally associated with more aggressive behavior and a higher risk of distant metastasis, while pathologic complete response (pCR) after neoadjuvant chemotherapy is strongly linked to better survival outcomes.

20 May 2026

Sino Biological launches XPressMAX™ Cell-Free Protein Synthesis Kit, accelerating AI-powered high-throughput antibody drug discovery

Sino Biological, Inc., a global leader in recombinant technology, is proud to announce the launch of its innovative XPressMAX™ Cell-Free Protein Synthesis Kit (Cat#: CFKIT02) , a cutting-edge solution designed to supercharge artificial intelligence (AI)-driven high-throughput screening pipelines for antibody drug discovery.

From Sino Biological Inc. 20 May 2026

Researchers uncover new genetic links influencing blood lipid composition

DZNE researchers have generated new insights into how the human genome shapes the chemical composition and concentration of blood lipids.

20 May 2026

Biomimetic nanocomposite hydrogel promotes tendon healing and tissue regeneration

The new system, termed KGN@PB@CM, combines several advanced elements. Prussian blue (PB) nanozymes act as potent reactive oxygen species (ROS) scavengers, while kartogenin (KGN)-a small molecule that promotes stem cell migration and tenogenic differentiation-is loaded onto the PB core.

20 May 2026