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Research suggests link between epilepsy and bipolar disorder

Research at Royal Holloway University of London, has suggested a link between patients with epilepsy and patients with bipolar disorder, through investigating a medicine used to treat both disorders.

21 Aug 2018

Researchers discover new promising target point for cancer and diabetes therapies

If certain signaling cascades are misregulated, diseases like cancer, obesity and diabetes may occur. A mechanism recently discovered by scientists at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie in Berlin and at the University of Geneva has a crucial influence on such signaling cascades and may be an important key for the future development of therapies against these diseases.

15 Aug 2018

Scientists discover key vulnerability of mixed lineage leukemia

Childhood leukemia is a diagnosis that no family ever wants to endure. While the treatment of most types of leukemia has improved steadily over the years, a few specific types remain very difficult to treat.

13 Aug 2018

Researchers shed new light on how bacteria sense nutrients in their environment

University of Leicester researchers have shed new light on how bacteria sense nutrients in their environment - which could provide important knowledge in the development of drugs and antibiotics to combat a range of diseases including tuberculosis.

3 Aug 2018

Tumor suppressor gene PTEN may be potential Achilles heel for breast cancer cells

In an article published July 17, 2018 by Nature Communications, a highly collaborative team of researchers at the Medical University of South Carolina and Ohio State University report that normal breast cells can prevent successful radiation treatment of breast cancer due to dysregulation between tumor suppressors and oncogenes.

2 Aug 2018

Scientists uncover molecular 'switch' that may control the benefits of exercise

Some people respond well to both aerobic exercise and strength training, while others don't. And some of us respond well to only one of those things, but not both. Scientists at Joslin Diabetes Center now have uncovered a surprising molecular "switch" that may help to explain why this happens.

2 Aug 2018

Protein known to drive nerve cell survival may protect children from Duchenne cardiomyopathy

A protein known to drive nerve cell survival in the brain and spinal cord might also protect failing hearts in children and young adults with Duchenne muscular dystrophy, according to preliminary research presented at the American Heart Association's Basic Cardiovascular Sciences Scientific Sessions, a premier global exchange of the latest advances in basic cardiovascular science.

2 Aug 2018

New drug discovery system allows scientists to target ‘undruggable’ enzymes

A new drug discovery system allows scientists to specifically target members of an important family of enzymes, called phosphatases, which were previously considered mostly "undruggable".

27 Jul 2018

Newly identified target may lead to discovery of treatments for chronic inflammatory diseases

Inflammation is part of the body's natural healing process. But when it becomes chronic, inflammation can lead to cancer, Alzheimer's disease and other conditions.

26 Jul 2018

New combination approach may help crush resistance to treatment in lung cancer patients

New-generation lung cancer drugs have been effective in a large number of patients, but within about a year, the patients tend to develop resistance to the therapy.

26 Jul 2018

Researchers identify enzyme as potential new drug target for blood disorders

Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to treat sickle cell disease.

20 Jul 2018

New proteomics studies help gain more insights into Alzheimer's, cancer and listeriosis

The brains of people with Alzheimer's disease contain many protein aggregates outside of cells, known as plaques. These are mainly made of the peptide amyloid-beta, which is released from the plasma membrane when the protease BACE1 cleaves its membrane-anchored precursor protein.

19 Jul 2018

Inflection Biosciences' dual mechanism inhibitor shows promise as treatment for CLL

Inflection Biosciences Ltd, a private company developing innovative therapeutics for cancer, today announced the publication of preclinical data showing the company's dual mechanism PIM/PI3 kinase inhibitor IBL-202 has promise as a treatment for chronic lymphocytic leukemia.

17 Jul 2018

Homogenous BTK occupancy assay used in tirabrutinib clinical studies

In a new SLAS Discovery article, Helen Yu and a team of researchers at Gilead Sciences, Inc. present a time-resolved fluorescence resonance energy transfer-based Bruton's tyrosine kinase occupancy assay that can measure target engagement in peripheral blood mononuclear cells and in lymph-node and bone-marrow samples.

17 Jul 2018

Study delves into the role played by Protein Kinase C in synaptic plasticity

Inside the brain, is a complex symphony of perfectly coordinated signaling. Hundreds of different molecules amplify, modify and carry information from tiny synaptic compartments all the way through the entire length of a neuron.

17 Jul 2018

Researchers describe key role of enzyme in regulating immune response against Chagas disease parasite

In an article published recently in the journal Nature Communications, researchers affiliated with the University of São Paulo in Brazil describe the central role played by an enzyme called phosphatidylinositol 3-kinase gamma in regulating the immune response against Trypanosoma cruzi, the protozoan parasite that causes Chagas disease.

16 Jul 2018

New drug strategy can alleviate multiple behavioral, cellular deficiencies in FXS mouse model

Research in mice shows that a pharmacological strategy can alleviate multiple behavioral and cellular deficiencies in a mouse model of fragile X syndrome, the most common inherited form of intellectual disability and a major single-gene cause of autism spectrum disorders.

13 Jul 2018

UZH scientists identify enzyme that controls cell division

When a cell divides, its constituents are usually evenly distributed among the daughter cells. UZH researchers have now identified an enzyme that guarantees that cell constituents that are concentrated in organelles without a membrane are properly distributed.

12 Jul 2018

Research reveals new gears in the circadian clock

A long-studied factor controlling human sleep cycles actually has two forms, one that keeps a key protein stable and another that promotes its degradation.

12 Jul 2018

Researchers uncover molecular drivers of a deadly pediatric cancer

Researchers have made important discoveries about the molecular mechanisms driving acute myeloid leukemia (AML), a deadly pediatric cancer.

11 Jul 2018

Kinase News and Research

Research suggests link between epilepsy and bipolar disorder

Researchers discover new promising target point for cancer and diabetes therapies

Scientists discover key vulnerability of mixed lineage leukemia

Researchers shed new light on how bacteria sense nutrients in their environment

Tumor suppressor gene PTEN may be potential Achilles heel for breast cancer cells

Scientists uncover molecular 'switch' that may control the benefits of exercise

Protein known to drive nerve cell survival may protect children from Duchenne cardiomyopathy

New drug discovery system allows scientists to target ‘undruggable’ enzymes

Newly identified target may lead to discovery of treatments for chronic inflammatory diseases

New combination approach may help crush resistance to treatment in lung cancer patients

Researchers identify enzyme as potential new drug target for blood disorders

New proteomics studies help gain more insights into Alzheimer's, cancer and listeriosis

Inflection Biosciences' dual mechanism inhibitor shows promise as treatment for CLL

Homogenous BTK occupancy assay used in tirabrutinib clinical studies

Study delves into the role played by Protein Kinase C in synaptic plasticity

Researchers describe key role of enzyme in regulating immune response against Chagas disease parasite

New drug strategy can alleviate multiple behavioral, cellular deficiencies in FXS mouse model

UZH scientists identify enzyme that controls cell division

Research reveals new gears in the circadian clock

Researchers uncover molecular drivers of a deadly pediatric cancer

Measuring Drug-Target Residence Times with Biochemical Assays eBook

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