Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Johns Hopkins researchers design tiny, star-shaped microdevices to deliver drugs

Inspired by a parasitic worm that digs its sharp teeth into its host's intestines, Johns Hopkins researchers have designed tiny, star-shaped microdevices that can latch onto intestinal mucosa and release drugs into the body.

3 Nov 2020

Thermo Fisher Scientific and Symphogen extend collaboration to boost drug discovery and development

Thermo Fisher Scientific, the world leader in serving science, and Symphogen, an affiliate of and the antibody center of excellence within the international pharmaceutical company, Servier, announce the extension of a strategic collaboration to deliver industry-proven, innovative characterization and quality control workflows for the simplified analysis of complex therapeutic proteins to advance biopharmaceutical discovery and development.

From Thermo Fisher Scientific Inc. 2 Nov 2020

Researchers develop new, improved human-skin equivalent

Researchers at the RIKEN Center for Biosystems Dynamics Research (BDR) have developed an improved human-skin equivalent that reproduces traction-force balance in the lateral direction, a property that controls the structure and physiological function of skin.

30 Oct 2020

Research projects receive BTCA grants to develop novel drugs for various diseases

Five research projects with exceptional promise to deliver new life-changing and health-altering therapies have received the inaugural Blavatnik Therapeutics Challenge Awards (BTCA) at Harvard Medical School.

30 Oct 2020

Time machine suggests a drug testing approach for pancreatic cancer

Many patients with pancreatic cancer have only about a 10% chance of survival within five years of their diagnosis because they tend to become resistant to chemotherapy, past studies have indicated.

30 Oct 2020

Research program aims to thwart prion-like spread of tau pathology in Alzheimer’s disease

Tangles of misfolded tau proteins in the brain are closely associated with memory loss in patients with Alzheimer's disease. In order for this tau pathology to spread, the protein must interact with heparan sulfate, a sugar molecule found on the surface of neurons.

28 Oct 2020

Deep learning models help hunt for COVID-19 drugs

Michigan State University Foundation Professor Guowei Wei wasn't preparing machine learning techniques for a global health crisis. Still, when one broke out, he and his team were ready to help.

28 Oct 2020

CN Bio announces launch of drug metabolism and safety toxicity testing services

CN Bio, a leading 3D cell culture company, that has developed single and multi-organ microphysiological systems to improve the accuracy and efficiency of drug discovery, today announced the commercial launch of its Drug Metabolism and Safety Toxicity Testing Services.

28 Oct 2020

Stewart Kay joins Adaptate Biotherapeutics as Chief Business Officer

Adaptate Biotherapeutics, a company focused on developing antibody-based therapeutics for modulation of gamma delta T cells, today announced the appointment of Stewart Kay as Chief Business Officer.

28 Oct 2020

Advancements in research on cancer signal transduction and treatment

Cancer is driven by numerous genetic and epigenetic changes occurring at the cellular level. These changes drive normal cells to proliferate and escape processes that usually regulate their survival and migration.

27 Oct 2020

Cleveland Clinic-led study identifies features associated with pathogenic and benign variants

An international team of researchers led by Cleveland Clinic's Lerner Research Institute has performed for the first time a wide-scale characterization of missense variants from 1,330 disease-associated genes.

27 Oct 2020

Novel machine learning algorithm helps find drug binding sites

Scientists from the iMolecule group at Skoltech Center for Computational and Data-Intensive Science and Engineering developed BiteNet, a machine learning algorithm that helps find drug binding sites, i.e. potential drug targets, in proteins.

27 Oct 2020

New peptide derivatives that target the SARS-CoV-2 spike protein

In a new study published in the journal Cellular and Molecular Bioengineering, researchers report peptide derivatives, or peptidomimetics, based on the circle residues involved in the interaction of the spike protein and ACE2.

26 Oct 2020

Deep Longevity collaborates with Longenesis on federated learning and consent management

Regent Pacific Group Limited ("Regent Pacific" or the "Company" and together with its subsidiaries, the "Group"; SEHK:0575.HK) today announced that Deep Longevity, Inc, a company recently acquired by the Group which mainly engaged in the development of explainable artificial intelligence systems to track the rate of aging at the molecular, cellular, tissue, organ, system, physiological, and psychological levels, has entered into a partnership with Longenesis, a leader in consent-enabled safe data curation for research.

23 Oct 2020

Dexamethasone drug may not benefit COVID-19 patients with diabetes or low albumin levels

A new discovery about how the body transports dexamethasone, a drug that can increase the survival chances of patients with severe COVID-19, suggests diabetes and other factors may reduce its potentially lifesaving effectiveness.

23 Oct 2020

New technique uses light to modify disease signaling

Most diseases are caused by aberrant cell signaling processes and basic research in cell signaling is needed to identify targets for future therapeutic approaches, especially in cases where no cures or effective treatments are currently available.

22 Oct 2020

Monoclonal Antibodies: Discovery, Characterization and Challenges

In this interview, News-Medical talks to David Apiyo, a senior manager of applications at Sartorius AG, about monoclonal antibody development and characterization.

22 Oct 2020

Researchers identify new mechanism that modulates cell division

Collaborative work of research groups at the University of Würzburg and the TU Dresden has provided important new insights for cancer research.

22 Oct 2020

Scientists discover key enzyme involved in the development of autoimmune diseases

Scientists affiliated with the Center for Research on Inflammatory Diseases (CRID http://crid.fmrp.usp.br), hosted by the University of São Paulo (USP) in Brazil, have discovered that an enzyme involved in key metabolic processes also plays a role in immune cell differentiation and hence in the development of autoimmune diseases.

19 Oct 2020

NAM announces winners of the inaugural round of Healthy Longevity Catalyst Awards

The National Academy of Medicine, together with seven global collaborators representing nearly 50 countries and territories, today announced the winners of the inaugural round of Healthy Longevity Catalyst Awards.

16 Oct 2020

Drug Discovery News and Research

Further Reading

Johns Hopkins researchers design tiny, star-shaped microdevices to deliver drugs

Thermo Fisher Scientific and Symphogen extend collaboration to boost drug discovery and development

Researchers develop new, improved human-skin equivalent

Research projects receive BTCA grants to develop novel drugs for various diseases

Time machine suggests a drug testing approach for pancreatic cancer

Research program aims to thwart prion-like spread of tau pathology in Alzheimer’s disease

Deep learning models help hunt for COVID-19 drugs

CN Bio announces launch of drug metabolism and safety toxicity testing services

Stewart Kay joins Adaptate Biotherapeutics as Chief Business Officer

Advancements in research on cancer signal transduction and treatment

Cleveland Clinic-led study identifies features associated with pathogenic and benign variants

Novel machine learning algorithm helps find drug binding sites

New peptide derivatives that target the SARS-CoV-2 spike protein

Deep Longevity collaborates with Longenesis on federated learning and consent management

Dexamethasone drug may not benefit COVID-19 patients with diabetes or low albumin levels

New technique uses light to modify disease signaling

Monoclonal Antibodies: Discovery, Characterization and Challenges

Researchers identify new mechanism that modulates cell division

Scientists discover key enzyme involved in the development of autoimmune diseases

NAM announces winners of the inaugural round of Healthy Longevity Catalyst Awards

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