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Discovery of a receptor that appears to function as one "lock" that HSV opens to allow it to enter human cells

It's one of the most common viruses in America, and one that causes the most guilt and shame. It can get inside almost any kind of human cell, reproduce in vast numbers, and linger for years in the body, causing everything from recurrent genital blisters to sores around the mouth. Its complications can kill, and it may increase susceptibility to many nerve and brain disorders.

24 Jul 2005

Fertility drugs may be ineffective for women who lack a gene called the estrogen receptor beta

"What we found is that the beta estrogen receptor plays a role in moving the egg outside the ovary so it can be fertilized," said Kenneth Korach, Ph.D., Laboratory Chief at the National Institute of Environmental Health Sciences (NIEHS) where the research was conducted. "We never knew before what function this receptor played in reproduction."

20 Jul 2005

Potential use of NH neurotransmitters as novel source for psychiatric drugs

Physiologists and medical researchers have long recognized the important endocrine roles played by the pituitary hormones oxytocin (OT) and vasopressin (VP) on peripheral systems in lactation, uterine contraction and urine concentration.

19 Jul 2005

Spontaneous contractions suppressed in late-term rat pregnancy

A long-time aim of obstetrical research has been to find agents that could delay or diminish pre-term labor because even today pre-term birth is a leading cause of infant mortality and morbidity.

19 Jul 2005

Variant of a common protein plays a primary role in Type 2 diabetes and obesity

Scientists in France and the United States report that a variant of a common protein plays a primary role in Type 2 diabetes and obesity, key features of the "insulin resistance syndrome" that affects more than 50 million people in this country and a similar number in Europe.

19 Jul 2005

Results demonstrate the safety and tolerability of ABthrax treatment for Anthrax infection

Human Genome Sciences has announced that results published in the current issue of Clinical Infectious Diseases demonstrate that the first investigational agent against anthrax infection to be evaluated in a clinical study since the 2001 anthrax attacks in the United States, is safe, well tolerated and achieves the blood levels predicted by relevant animal models as necessary to afford significant protection from the lethal effects of the anthrax toxin

19 Jul 2005

Would boosting the oxytocin (OT) hormonal system lead to longer breast-feeding?

There's little controversy about the benefits of breastfeeding infants over giving them formula. Mother's milk is the perfect food, providing exactly the correct nourishment for newborns, while protecting them from many illnesses.

19 Jul 2005

Hormonal signaling systems and their role in sex drive

Two University of Edinburgh professors from the Centre for Integrative Physiology describe how "our understanding of how the brain processes information is undergoing a radical shift as we begin to recognize the implications of hormonal signaling systems within the brain itself," explained Gareth Leng.

19 Jul 2005

Studies explore genetic interactions between two well-known tumor suppressor proteins, PTEN and TSC2

Two papers in the August 1 issue of Genes & Development explore the genetic interactions between two well-known tumor suppressor proteins, PTEN and TSC2.

19 Jul 2005

Nerve cells can also release neurotransmitters outside of synapses

Every neurobiology textbook invariably states that nerve cells communicate with each other through synapses, the specialized cell-cell contacts found at the end of the cells' threadlike extensions. In the journal Science, researchers at the Salk Institute for Biological Sciences and the University of California at San Diego report that nerve cells, or neurons, may not have to rely on traditionally defined synapses to "talk" to each other.

18 Jul 2005

Oxytocin raises aggression, cuts anxiety during lactation

Maternal aggressive/protective behavior is recognized throughout mammalian species, especially during lactation. When hiking, we warn our kids not to approach bear cubs, or to get between a cub and the mother. While driving and you see a fawn, you know a doe can't be too far away and will run headlong to protect it.

18 Jul 2005

RNA dynamics may help in drug design

Biophysicists have developed a method for studying, in real time, a nanoscale "docking and undocking" interaction between small pieces of ribonucleic acid (RNA), a technique that may be broadly useful in studying structural changes in RNA that affect its function.

17 Jul 2005

Scientists have begun to clarify how one of the body's molecules controls the trafficking of T cells through the blood

...lymph nodes and on to tissues to fight infection -- a crucial response that sometimes goes awry, attacking the body's own tissues and causing autoimmune diseases.

17 Jul 2005

Data directly support a pathogenetic model of acute leukemia

Acute myeloid leukemia (AML) is frequently caused by genetic alterations that affect transcription factors, such as AML1-ETO and mutations affecting genes involved in signal transduction pathways, such as FLT3.

15 Jul 2005

Erlotinib increases survival in patients with advanced non-small cell lung cancer

An international clinical study led by Canadian researchers has demonstrated that a drug called erlotinib increases survival in patients with advanced non-small cell lung cancer who typically have no other treatment options.

13 Jul 2005

Researchers gain better understanding of how nerves need to be reconnected after spinal cord injury

Nerve cells relay messages at blink-of-the-eye speeds by squirting chemicals called neurotransmitters across tiny gaps called synapses to awaiting message receptors. But lots of different receptors and neurotransmitters work simultaneously. Which goes where to send the proper message?

13 Jul 2005

Biologists determine structure of a common-cold virus

Biologists at Purdue University have determined the combined structure of a common-cold virus attached to a molecule that enables the virus to infect its host, information that ultimately may help researchers develop methods for treating certain viral infections.

13 Jul 2005

Receptor News and Research

Discovery of a receptor that appears to function as one "lock" that HSV opens to allow it to enter human cells

Fertility drugs may be ineffective for women who lack a gene called the estrogen receptor beta

Potential use of NH neurotransmitters as novel source for psychiatric drugs

Spontaneous contractions suppressed in late-term rat pregnancy

Variant of a common protein plays a primary role in Type 2 diabetes and obesity

Results demonstrate the safety and tolerability of ABthrax treatment for Anthrax infection

Would boosting the oxytocin (OT) hormonal system lead to longer breast-feeding?

Hormonal signaling systems and their role in sex drive

Studies explore genetic interactions between two well-known tumor suppressor proteins, PTEN and TSC2

Nerve cells can also release neurotransmitters outside of synapses

Oxytocin raises aggression, cuts anxiety during lactation

RNA dynamics may help in drug design

Scientists have begun to clarify how one of the body's molecules controls the trafficking of T cells through the blood

Data directly support a pathogenetic model of acute leukemia

Erlotinib increases survival in patients with advanced non-small cell lung cancer

Researchers gain better understanding of how nerves need to be reconnected after spinal cord injury

Biologists determine structure of a common-cold virus

Research shows key difference between the eye's light-detecting system and the nose's odor-detecting system

Approval sought for Femara in early post-surgery use

Serotonin may play a role in maintaining circadian rhythm

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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