Therapeutics News and Research

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Scientists awarded $7.7 million grant to develop treatment for rare brain disorder

Children born with a damaged gene needed for healthy brain development, SYNGAP1, experience seizures, sensory processing disorders, difficulty speaking, intellectual disability, and autism-like behaviors.

13 Aug 2024

Generative AI in genetics: Effective but needs monitoring for consistency

Samuel (Sandy) Aronson, ALM, MA, executive director of IT and AI Solutions for Mass General Brigham Personalized Medicine and senior director of IT and AI Solutions for the Accelerator for Clinical Transformation, is the corresponding author of a paper published in NEJM AI that looked at whether generative AI could hold promise for improving scientific literature review of variants in clinical genetic testing.

13 Aug 2024

Researchers develop new method to study critical type of protein modification process

Human proteins undergo a variety of chemical modifications following their synthesis. These modifications regulate their structure, function, and stability.

12 Aug 2024

New perspectives on targeting BRAF alterations in cancer

A new research perspective was published in Oncotarget's Volume 15 on July 16, 2024, entitled, "Targeting the multifaceted BRAF in cancer: New directions."

12 Aug 2024

New genomic predictors of relapse in childhood B-cell acute lymphoblastic leukemia uncovered

Scientists from St. Jude Children's Research Hospital, Seattle Children's and the Children's Oncology Group (COG) have identified novel genetic variations that influence relapse risk in children with standard risk B-cell acute lymphoblastic leukemia (SR B-ALL), the most common childhood cancer.

12 Aug 2024

Study reveals how NPAS4 regulates drug-context associations and impacts relapse

Most people wouldn't think twice after seeing sugar spilled on a counter. But for someone with a history of cocaine use, this visual cue could trigger powerful associations with their past drug use and a compulsive urge to seek the drug.

9 Aug 2024

Novel molecular signaling pathway found to play a crucial role in maintaining the skin barrier

Our skin–the body's largest organ–provides the first line of defense against infections and many other threats to our health.

9 Aug 2024

Machine learning revolutionizes gene delivery

Gene therapy could potentially cure genetic diseases but it remains a challenge to package and deliver new genes to specific cells safely and effectively. Existing methods of engineering one of the most commonly used gene-delivery vehicles, adeno-associated viruses (AAV), are often slow and inefficient.

9 Aug 2024

AI unlocks secrets of gastric cancer development

Gastric cancer, a significant global health challenge, is characterized by a complex transition from inflammation-induced premalignant lesions to malignancy. The quest for early diagnosis and prevention is impeded by the intricate biological shifts that mark this journey, highlighting an urgent need for a deeper dive into the underlying the multi-level and dynamic features.

8 Aug 2024

Houston Methodist pioneers new technique for targeted drug delivery to the brain

Houston Methodist researchers have discovered a more accurate and timely way to deliver life-saving drug therapies to the brain, laying the groundwork for more effective treatment of brain tumors and other neurological diseases.

8 Aug 2024

Study links renalase-1 and T-cell receptor interaction to increased melanoma survival

A new research paper was published in Oncotarget's Volume 15 on August 5, 2024, entitled, "Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival."

8 Aug 2024

NIH awards $3.5M grant to study link between traumatic brain injury and Alzheimer's

A traumatic brain injury, or TBI, is caused by a contusion to the head that may result in injury to the brain.

8 Aug 2024

Drug shows new promise in treating breast cancer with brain metastases or recurrent glioblastoma

A drug effective in treating breast cancer shows new promise in addressing breast cancer with brain metastases or recurrent glioblastoma, as reported by results of a prospective window-of-opportunity trial at the University of Texas Health Science Center at San Antonio (UT Health San Antonio).

8 Aug 2024

C-Path supports innovative ALS, neurodegenerative disease research with new grant

Critical Path Institute's (C-Path) Translational Therapeutics Accelerator (TRxA) announced today a new research grant awarded to Daniela C. Zarnescu, Ph.D., Professor of Cellular and Molecular Physiology at Penn State University College of Medicine, in collaboration with Jon Njardarson, Ph.D., Professor at the University of Arizona.

8 Aug 2024

Gene activity can predict severe side effects from melanoma treatment

An activity pattern in certain genes responsible for building proteins known as spleen tyrosine kinases can predict which melanoma patients are likely to have severe side effects from immunotherapy designed to treat the most deadly skin cancer, a new study shows.

8 Aug 2024

Consuming foods with erythritol increases risk of cardiovascular events, study shows

New Cleveland Clinic research shows that consuming foods with erythritol, a popular artificial sweetener, increases risk of cardiovascular events such as heart attack and stroke.

8 Aug 2024

How little Denmark got homegrown giant Novo Nordisk to lower ozempic prices

On May 13, Sen. Bernie Sanders (I-Vt.) published an open letter to Novo Nordisk on the front page of a leading Danish newspaper, urging the hometown company to live up to its altruistic standards by lowering U.S. prices for its blockbuster diabetes and weight loss drugs.

8 Aug 2024

Decoding glioblastoma: New insights into molecular subtypes and mesenchymal transition mechanisms

Glioblastoma multiforme (GBM) stands as a formidable adversary in oncology, characterized by its molecular complexity and relentless progression.

7 Aug 2024

METRNL protein identified as key player in cancer progression

A protein called Meteorin-like (METRNL) in the tumor microenvironment saps energy from T cells, thereby severely limiting their ability to fight cancer, according to new research directed by investigators at the Johns Hopkins University School of Medicine and the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy. Finding ways to block the effects of METRNL signaling on tumor-infiltrating T cells may allow these immune cells to regain the energy necessary to eliminate tumors.

7 Aug 2024

Innovative nasal spray and vaccine for respiratory virus protection

A team of researchers, led by the University of Houston, has discovered two new ways of preventing and treating respiratory viruses.

6 Aug 2024

Therapeutics News and Research

Scientists awarded $7.7 million grant to develop treatment for rare brain disorder

Generative AI in genetics: Effective but needs monitoring for consistency

Researchers develop new method to study critical type of protein modification process

New perspectives on targeting BRAF alterations in cancer

New genomic predictors of relapse in childhood B-cell acute lymphoblastic leukemia uncovered

Study reveals how NPAS4 regulates drug-context associations and impacts relapse

Novel molecular signaling pathway found to play a crucial role in maintaining the skin barrier

Machine learning revolutionizes gene delivery

AI unlocks secrets of gastric cancer development

Houston Methodist pioneers new technique for targeted drug delivery to the brain

Study links renalase-1 and T-cell receptor interaction to increased melanoma survival

NIH awards $3.5M grant to study link between traumatic brain injury and Alzheimer's

Drug shows new promise in treating breast cancer with brain metastases or recurrent glioblastoma

C-Path supports innovative ALS, neurodegenerative disease research with new grant

Gene activity can predict severe side effects from melanoma treatment

Consuming foods with erythritol increases risk of cardiovascular events, study shows

How little Denmark got homegrown giant Novo Nordisk to lower ozempic prices

Decoding glioblastoma: New insights into molecular subtypes and mesenchymal transition mechanisms

METRNL protein identified as key player in cancer progression

Innovative nasal spray and vaccine for respiratory virus protection

Advancing therapeutic biopolymer development eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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