Calcification News and Research

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Mizzou researchers explore first drug treatment for aortic valve calcification

University of Missouri researchers are advancing a promising new approach to treating a serious heart condition that affects millions of older adults worldwide.

1 Sep 2026

REACT study maps widespread silent atherosclerosis across adult lifespan

Silent atherosclerosis was detectable from early adulthood and showed sex-specific patterns of growth with age, according to results from the REACT study presented in a Hot Line session today at ESC Congress 2026 and published simultaneously in the New England Journal of Medicine.

29 Aug 2026

New heart assembloid model mimics complex valve disorders

A multi-disciplinary, multi-institution group of researchers focused their expertise in genetics, mechanics, chemistry and biology on a chip the size of a postage stamp in order to model a particular class of heart conditions.

11 Aug 2026

Cellular senescence drives progression of spinal disc degeneration and pain

A growing body of scientific insight is drawing attention to cellular senescence as a central force in the progression of intervertebral disc degeneration (IDD), a leading contributor to chronic low back pain worldwide.

5 Aug 2026

New ARPA-H grant aims to advance genomic medicines for rare vascular diseases

Massachusetts General Hospital, a founding member of the Mass General Brigham healthcare system, has been awarded an Advanced Research Projects Agency for Health (ARPA-H) contract to develop advanced personalized genomic medicines to treat rare genetic vascular diseases.

21 Jul 2026

Gum disease bacteria linked to calcific aortic valve stenosis

Gum disease bacteria may spur calcium buildup in the heart's aortic valve, leading to a common and serious heart valve disease, according to preliminary, independent research presented at the American Heart Association's Basic Cardiovascular Sciences Scientific Sessions 2026.

12 Jul 2026

New drug candidate treats severe fatty liver disease by improving gut health

Researchers discovered that a potential drug developed at Michigan Medicine treats severe fatty liver disease by improving gut health, according to a study published in The Journal of Clinical Investigation.

7 Jul 2026

Unexplained skin darkening leads to life-saving Addison's disease diagnosis

A 24-year-old woman presented with two years of unexplained darkening of her hands, feet, gums, and tongue.

26 Jun 2026

Interactive AI model improves explainable lung cancer diagnosis from CT scans

Lung cancer remains one of the leading causes of cancer-related deaths worldwide, making early and accurate diagnosis essential for improving patient outcomes.

12 May 2026

Molecular switch in mice links energy burning and bone health

Scientists' discovery of a molecular "switch" that activates an energy‑burning pathway in mice has the potential to lead to new treatments for bone disease.

11 May 2026

AI and CRISPR technologies drive proactive health monitoring

JMIR Publications today featured two new stories in its News and Perspectives section, highlighting a shift toward proactive, tech-integrated health monitoring.

30 Apr 2026

M-TEER procedure effectively treats mitral regurgitation in patients with calcification

Results from a new analysis show that patients with mitral annular calcification (MAC) who undergo minimally invasive mitral transcatheter edge-to-edge repair (M-TEER) experience similar reductions in mitral regurgitation (MR) and improvement in quality of life compared to those seen in patients without calcification.

24 Apr 2026

Specific intestinal fungi play role in the pathogenesis of MASLD and cardiovascular disease

Metabolic dysfunction-associated steatotic liver disease (MASLD) is an independent risk factor for cardiovascular disease (CVD). While gut bacteria have been linked to CVD, the role of intestinal fungi in subclinical coronary atherosclerosis (SCA) remains unclear.

23 Apr 2026

Study reveals limitations of large language models in medical diagnostics

Artificial intelligence (AI) is rapidly transforming healthcare. AI systems can now detect diabetic eye disease from retinal photos and analyze CT images for signs of early-stage lung cancers and stroke.

16 Mar 2026

Case report describes treatment of rare calcified solid pseudopapillary pancreatic tumor

A new case report was published in Volume 13 of Oncoscienceon February 7, 2026, titled "Massive calcified solid pseudopapillary neoplasm of the pancreatic head."

6 Mar 2026

BCAT2 enzyme identified as a target for diabetic foot recovery

Diabetic macrovascular complications are the main cause of death and disability in diabetes patients, of which vascular calcification is one of the key pathological mechanisms. Calcification in atherosclerotic plaque can cause stiffness and decreased compliance of the vascular wall, and induce atherosclerotic plaque rupture, which increases the risk of acute cardiovascular events.

6 Mar 2026

Study explores how reversible RNA editing could transform future cardiovascular medicine

This mini-review synthesises evidence showing that adenosine-to-inosine RNA editing plays an important regulatory role in cardiovascular development, cellular homeostasis, and disease biology. It highlights emerging links between dysregulated RNA editing and cardiovascular conditions while outlining biomarker potential and reversible RNA-editing therapeutic strategies that remain under investigation.

15 Feb 2026

Osteoprotegerin links bone metabolism to cardiovascular disease

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Osteoprotegerin (OPG), a glycoprotein in the tumor necrosis factor superfamily, regulates bone metabolism by suppressing the formation and activation of osteoclasts.

13 Feb 2026

FIU establishes hub for cardiovascular innovation

With cardiovascular disease remaining the leading cause of death in the United States, this Heart Month (February), FIU is establishing an interdisciplinary center designed to accelerate breakthroughs in heart disease research, education, and innovation.

30 Jan 2026

Breast arterial calcification on mammograms predicts future heart risk

Routine mammograms are a critical tool for breast cancer screening. However, they may also hold crucial, potentially untapped information about a person's risk for cardiovascular disease, the number one cause of death among adults.

11 Dec 2025