Estradiol News and Research

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Estradiol is a sex hormone. Mislabelled the "female" hormone, it is also present in males; it represents the major estrogen in humans. Estradiol has not only a critical impact on reproductive and sexual functioning, but also affects other organs including the bones.

Menopause leaves a blood protein signature linked to brain aging and Alzheimer’s risk

Researchers identified a 16-protein blood signature associated with menopause that tracked more strongly with reproductive hormones than chronological age and was largely replicated in an independent UK Biobank cohort. Higher menopause proteomic scores were also associated with less favorable proteomic aging estimates and poorer cognitive outcomes in older women, including incident Alzheimer’s dementia, although the observational evidence does not establish causality.

23 Sep 2026

Hormonal shifts alter brain patterns linked to female mood

During the menstrual cycle, when progesterone levels are higher, patterns of brain activity emerge that make it more difficult to distinguish between less and more emotionally demanding situations.

23 Sep 2026

New indicators could accelerate development of anti-aging drugs

Twelve candidate indicators, based on studies in mice, could make developing anti-aging interventions faster-while offering new insights into age-related diseases.

17 Sep 2026

Shatavari may affect more than hormones, and the gut could help explain why

A review in Nutrients examined how bioactive compounds in Asparagus racemosus (Shatavari) may influence cognitive health through the microbiota-gut-brain axis, estrogen-related signaling, neuroinflammation, oxidative stress, and neurotransmitter regulation. Evidence from computational, cellular, animal, and limited human studies suggests several plausible biological pathways, but key questions remain about bioavailability, brain exposure, dosing, and clinical efficacy.

16 Sep 2026

Progesterone levels linked to brain patterns underlying mood changes

The influence of the hormone progesterone on mood is well known. Now researchers from the University of Barcelona have shown how higher levels of progesterone during the menstrual cycle are linked to less distinct patterns of activity in areas of the brain involved in controlling emotions.

2 Sep 2026

Estrogen hormone combination may help relieve menopausal brain fog

Many women going through menopause report struggling with memory lapses, trouble concentrating and slower thinking, a set of symptoms often described as "brain fog."

1 Sep 2026

Study links higher body fat to lower sperm counts despite normal BMI

Among 1,058 Danish men, higher body fat percentage was associated with lower total sperm count and altered reproductive hormone levels, but not testicular volume. Body fat percentage showed stronger links with several semen measures than BMI or waist-to-height ratio, with the sperm-count association strengthening among men with normal BMI.

2 Aug 2026

Waters launches industry's most sensitive and robust clinical IVD System with Xevo TQ Absolute XR IVD Mass Spectrometer

The Association for Diagnostics & Laboratory Medicine (ADLM) 2026 Annual Meeting – Waters Corporation today announced the launch of the Xevo TQ Absolute XR IVD Mass Spectrometer, expanding its MassTrak™ IVD System portfolio of LC-MS/MS Systems with a solution that combines class-leading sensitivity and enhanced robustness for clinical applications.

31 Jul 2026

Active birth control pills may increase emotional eating

Combined oral contraceptives are associated with increased emotional eating, suggesting hormonal effects on eating behaviors and potential binge eating risks.

9 Jul 2026

Could IVF affect heart health after pregnancy?

Women with IVF-conceived pregnancies exhibit higher large artery stiffness, indicating potential cardiovascular risks that warrant further investigation.

7 Jul 2026

Gut microbes emerge as potential players in estrogen-driven cancers

A new review maps how the endocrine-microbiome axis expands the estrobolome concept, showing that gut microbes may alter estrogen recycling, produce hormone-like metabolites, and shape inflammation and tissue environments in hormone-driven cancers. Human evidence remains mostly associative, so the authors call for causal models, longitudinal multi-omics, multi-kingdom profiling, and sex-stratified studies before microbiome-guided cancer strategies enter routine care.

25 Jun 2026

Estradiol changes may shape how much women move during the menstrual cycle

A 28-day wearable-sensor study of 26 healthy naturally menstruating women found that active energy expenditure varied across the menstrual cycle and was higher in the early follicular phase than the late follicular phase.

21 Jun 2026

Study links menopause and hormone therapy status to modifiable health behaviors

Menopause is associated with a number of adverse health effects, some of which can be mitigated by an array of modifiable health behaviors (MHBs), including diet, exercise, and sleep duration.

18 Jun 2026

PMOS rethink reframes a common hormone disorder as a whole-body disease

A new review reframes PCOS, now proposed as PMOS, as a systemic endocrine and metabolic disorder shaped by genetic, epigenetic, ovarian, metabolic, and neuroendocrine pathways. It highlights why inconsistent diagnosis and symptom-focused care have limited progress, while targeted therapies, biomarkers, machine learning, and organ-on-chip models may support more personalized treatment.

18 Jun 2026

Study links menstrual cycle timing to COVID vaccine side effects

A study of 1,474 Clue app users found that women vaccinated against COVID-19 during the follicular phase had higher odds of self-reported side effects than those vaccinated during the luteal phase.

8 Jun 2026

AI-driven hormone tracking could help detect infertility early and improve conception

Men and women who appear hormonally 'normal' may still have undetected disruptions in the timing and coordination of their reproductive hormones that could impair fertility, according to research presented at the 28th European Congress of Endocrinology in Prague.

8 May 2026

Vitamin E intake linked to a key fertility hormone in women trying to conceive

A cross-sectional study of 97 women with infertility found that higher vitamin E intake was associated with lower prolactin levels and smaller hip circumference. Riboflavin and calcium intake were linked to higher muscle mass percentage, but the findings are association-based and need confirmation in longitudinal studies.

26 Apr 2026

Research suggests randomness behind rare cases of twin ovulation

Each month during a woman's menstrual cycle, an ovary prepares 10-20 antral follicles, fluid filled sacs that hold immature eggs, for maturation.

22 Apr 2026

Having more children associated with lower stroke risk for women

While some say having lots of kids can make you lose your faculties, a new study suggests otherwise.

20 Apr 2026

Researchers map how menstrual cycle phases affect athletic performance

In a repeated-measures study of 18 eumenorrheic female athletes, half-squat strength was highest in the late follicular phase and around ovulation, while handgrip strength peaked in the late luteal phase. Psychological measures also shifted across the cycle, with lower vigor and higher fatigue and depression scores in the late luteal phase, supporting more individualized training monitoring.

12 Apr 2026