Fentanyl News and Research

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Fentanyl is a powerful synthetic opiate analgesic similar to but more potent than morphine. It is typically used to treat patients with severe pain, or to manage pain after surgery. It is also sometimes used to treat people with chronic pain who are physically tolerant to opiates. It is a schedule II prescription drug.

Light-activated experimental opioid eliminates dangerous side effects

Opioid painkillers are some of the strongest analgesic medicines, but they are also the riskiest owing to a range of side effects, including addiction.

15 Oct 2026

Well-designed electronic alerts improve care for cardiac patients

For busy health care workers, the electronic health record (EHR) can feel like an endless stream of clicks and prompts.

6 Oct 2026

Many youth with opioid use disorder miss out on treatment

One in 100 adolescents and young adults in the United States has an opioid use disorder (OUD) and, with the rise of fentanyl in the drug supply, overdoses in this age group have risen sharply since 2019.

5 Oct 2026

Veterinary sedative in fentanyl supply spikes severe withdrawal cases

A powerful veterinary sedative, medetomidine, is increasingly infiltrating the street supplies of the already deadly opioid fentanyl, with patients suffering from its withdrawal quadrupling in recent years, according to a new analysis by researchers at the Perelman School of Medicine at the University of Pennsylvania.

29 Sep 2026

Understanding opioid risks can help prevent accidental overdoses

According to numbers calculated from the CDC, approximately 80,000 people died last year from a drug overdose, which represents about 21 deaths per 100,000 residents in the U.S. alone. Overdose deaths are preventable, and in most of the cases we see, they are completely accidental.

24 Aug 2026

New UH Health initiative targets Texas healthcare workforce shortage

Addressing Texas' growing healthcare workforce shortage and rising demand for care, the University of Houston has launched UH Health, an academic health enterprise designed to integrate education, research and community engagement across the University.

11 Aug 2026

Researchers uncover brain target to counter fentanyl-induced slow breathing

Fentanyl causes symptoms that can lead to death from overdose. One of these symptoms is slow breathing, which deprives drug users of oxygen.

20 Jul 2026

Prenatal use of certain medications can harm developing fetal brain

A review article by a University of Nebraska Medical Center/Child Health Research Institute research team underscores and describes how altering fundamental brain development processes can be detrimental for the developing baby.

20 Jul 2026

Researchers identify opioids with highest risk of respiratory depression

University of Manchester researchers have identified which opioids are most likely to be associated with respiratory depression, in a major new study.

9 Jul 2026

Injectable opioid treatment sees rapid growth across the United States

There was a substantial increase in recent years in the use of a form of the primary medication to treat opioid use disorder, according to a Rutgers Health study.

7 Jul 2026

Naloxone provides life-saving tool to reverse opioid overdoses

Anyone can save a life during an opioid overdose with naloxone, a front-line defense in the nation's overdose crisis.

16 Jun 2026

Experimental vaccine protects against fentanyl and related opioids

Fentanyl and related variants of the synthetic opioid kill more Americans each year than car accidents and gun violence combined. In too-high doses, the drugs hijack brain chemistry and shut down the signals that control breathing.

11 Jun 2026

Falling fentanyl deaths drive historic drop in American drug overdoses

Researchers from the University of California San Diego have found that U.S. overdose death rates declined dramatically between 2023 and 2024, marking the first recorded drop in all four waves of the nation's overdose crisis.

2 Jun 2026

Vitamin D deficiency linked to higher postoperative breast cancer pain

Vitamin D deficiency is associated with more moderate to severe pain following breast cancer surgery and an increased consumption of opioid drugs, finds research published online in the journal Regional Anesthesia & Pain Medicine.

19 May 2026

ExiVex reports in-human pharmacokinetic data showing EMRX-101 intranasal naloxone approaches IV-like peak plasma concentrations with substantially faster Tmax than currently approved comparator

ExiVex Biopharma (formerly EmerRx Biopharma), a clinical-stage pharmaceutical company developing a proprietary dual-chamber intranasal drug delivery platform, today announced in-human pharmacokinetic (PK) data for its lead candidate EMRX-101, an intranasal naloxone product targeting opioid-induced respiratory depression.

From Hanson Wade Group - 4th Nasal Formulation & Delivery Summit 15 May 2026

Cardiometabolic diseases remain leading cause of excess American mortality

Between 1999 and 2022, the US had substantially higher death rates than other wealthy nations, largely due to cardiovascular disease, metabolic diseases (including diabetes), Alzheimer's disease and related dementias, and drug and alcohol complications.

8 May 2026

Opioid overdose survivors face elevated mortality risk within one year

After an emergency department visit for an opioid overdose, 9 per cent of individuals died and 21 per cent experienced a repeat opioid overdose in the following year, according to a new study from ICES and the Centre for Addiction and Mental Health (CAMH).

7 May 2026

TikTok chatter could help predict where the opioid crisis is heading next

A large-scale analysis of 569,581 TikTok comments found that opioid-related discussions may help track and forecast synthetic opioid overdose mortality in the US. Recovery, harm reduction, drug use, drug sourcing, and loss-related conversations provided near-real-time signals that improved 6-month forecasting accuracy.

28 Apr 2026

Environmental enrichment found to weaken stress-triggered fentanyl relapse

Combating the opioid crisis relies on identifying new prevention strategies for problematic fentanyl use. In a collaboration between Washington State University and Washington University in St. Louis, researchers led by Jose Moron tested whether enriching a rat's environment can reduce fentanyl use and relapse.

13 Apr 2026

Standard naloxone doses may not reverse newer synthetic opioid overdoses

A new study exposes challenges in reversing opioid overdoses with naloxone when potent synthetic drugs like fentanyl and sufentanil are involved, according to a study in the May 2026 issue of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA).

13 Apr 2026