Gluconeogenesis News and Research

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Gluconeogenesis (abbreviated GNG) is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as lactate, glycerol, and glucogenic amino acids.

Maternal obesity alters fetal liver metabolism via placental molecular signals

A mother's obesity during pregnancy may send molecular signals across the placenta that permanently alter her son's liver metabolism, according to a new study in mice published in Nature Communications.

26 Aug 2026

New review highlights FOXA2's role in glucose regulation pathways

A newly published review highlights the pivotal role of FOXA2, a key transcription factor, in coordinating pancreatic development, maintaining islet cell identity, and regulating glucose homeostasis.

6 Aug 2026

Bee-derived propolis shows potent antiviral activity against varicella-zoster virus

Announcing a new article publication for Zoonoses journal. Varicella-zoster virus (VZV) is a clinically important human neurotropic herpesvirus that causes varicella (chickenpox) as primary infection, typically in children.

5 Jun 2026

Thyroid hormone profiles provide critical prognostic clues for patients facing liver failure

Early and accurate prognostic assessment is crucial to prevent disease progression in liver failure. Thyroid hormones (THs), particularly triiodothyronine (T3), are key metabolic regulators and play an important role in liver regeneration. Liver failure is frequently complicated by non‑thyroidal illness syndrome (NTIS), characterized by low T3 with normal or slightly elevated TSH and T4.

14 May 2026

Five-target drug beats GLP-1/GIP therapy in obese diabetic mice

A Nature study reports a single-molecule GLP-1–GIP–lanifibranor quintuple agonist that targets incretin receptor-expressing cells while activating PPARα/γ/δ pathways. In obese and insulin-resistant mice, the compound reduced body weight, food intake, and hyperglycaemia more effectively than semaglutide or GLP-1R–GIPR co-agonism, while remaining a preclinical finding.

30 Apr 2026

Prickly pear may pack a surprising punch against metabolic syndrome

This narrative review examines how Opuntia ficus-indica fruit, or prickly pear, may help target multiple features of metabolic syndrome through its fiber, betalains, polyphenols, carotenoids, and other bioactive compounds. The authors conclude that the fruit shows promising mechanistic and preclinical potential, but stronger human trials are still needed before firm clinical claims can be made.

6 Apr 2026

Researchers show red blood cells drive better glucose tolerance at high altitude

Chronic hypoxia improves glucose tolerance in mice through insulin-independent mechanisms, with red blood cells acting as a major systemic glucose sink. Increased erythrocyte production and altered glycolytic flux help reduce circulating glucose while supporting oxygen delivery to tissues.

22 Feb 2026

Sterilized fermented beverage targets obesity and type 2 diabetes pathways in computational study

Researchers profiled a terminally sterilized probiotic-fermented MFH beverage and identified aporphine alkaloids and flavonoids with favorable predicted ADMET properties. Integrated network pharmacology, molecular docking, and 100-ns MD simulations suggest multi-target engagement of metabolic-inflammatory pathways relevant to obesity and type 2 diabetes.

9 Dec 2025

Study explores how elevated growth hormone levels contribute to liver aging

A new research paper was published in Volume 17, Issue 10 of Aging-US on October 3, 2025, titled "Growth hormone excess drives liver aging via increased glycation stress."

18 Nov 2025

Understanding leptin's dual function in MAFLD pathogenesis

Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as a predominant chronic liver condition globally, intricately linked with obesity, type 2 diabetes (T2DM), and metabolic syndrome.

14 Nov 2025

Shared gene signatures reveal metabolic dysfunction in liver cirrhosis and acute-on-chronic liver failure

Chronic liver cirrhosis (LC) and acute-on-chronic liver failure (ACLF) are interconnected hepatic disorders associated with substantial morbidity and mortality.

27 Aug 2025

Immune aging drives the progression of type 2 diabetes

Type 2 diabetes (T2D) is a global metabolic epidemic driven by insulin resistance (IR), chronic inflammation, and β-cell failure.

6 Aug 2025

New research reveals why fiber-rich diets fuel you better than refined foods

This study quantifies how much energy the human body harvests from gut microbial fermentation of dietary fiber, integrating bacterial physiology, diet, and metagenomic data. Results reveal that dietary fiber, not microbiome composition, mainly determines the amount of short-chain fatty acids absorbed, impacting daily energy and metabolic health.

31 Jul 2025

What’s better for your gut: lean beef or chicken? Science weighs in

A crossover trial in healthy young adults found that both lean chicken and beef diets reduced gut microbial richness, but only chicken caused significant diversity loss. The study highlights that lean local beef may have a milder impact on the gut microbiome than chicken.

29 Jul 2025

Hyaluronidase-1 emerges as a key regulator of postmeal blood sugar

A recent study published in Life Metabolism has uncovered a surprising new player in the body's ability to regulate blood sugar after eating.

15 May 2025

Study offers new insights into the harmful effects of sugar-sweetened beverages on human health

Researchers at the Advanced Research Unit on Metabolism, Development & Aging (ARUMDA), in the Tata Institute of Fundamental Research (TIFR, Mumbai and TIFR Hyderabad), have unveiled a comprehensive understanding of the harmful effects of sugar-sweetened beverages (SSBs) on human health, using a preclinical mouse model that closely mimics human consumption patterns.

21 Mar 2025