Herpes Simplex Virus News and Research

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Severe COVID-19 reactivates dormant viruses and may leave a lasting viral signature

A longitudinal study of 1,154 hospitalized COVID-19 patients found widespread reactivation of chronic Herpesviridae and Anelloviridae, with distinct viral patterns linked to disease severity, inflammation, and clinical outcomes. Anelloviridae also persisted during convalescence and were associated with physical deficits in long COVID, although the study did not establish causation.

7 Aug 2026

Mental health problems common in encephalitis survivors, study finds

A major new study has found that mental health and behavioral changes such as depression, anxiety, and emotional instability are common in people who survive encephalitis - inflammation of the brain that can be caused by infection or autoimmune disease.

18 Jun 2026

Research highlights ongoing TORCH infection risks despite rising vaccination rates

The TORCH complex is a group of pathogens that can cause infections with mild or silent symptoms in an expecting mother, but in a developing fetus can lead to serious complications that include stillbirth, lifelong disability, or birth defects.

8 Jun 2026

Antiviral drugs and shingles vaccines tied to lower dementia risk

New evidence links viral infections to dementia risk, suggesting vaccines and antiviral therapies may offer preventive pathways against cognitive decline.

8 Apr 2026

Scientists identify ANKIB1 as key regulator of innate immune signaling

Innate immune sensors – known as pattern recognition receptors (PRRs) – detect specific molecular components of bacterial or viral intruders.

6 Mar 2026

Scientists discover how herpes simplex virus softens cells to multiply faster

Herpes simplex virus partially liquifies the tightly packed, gel-like interior of human cell nuclei to copy itself faster, a new study shows.

6 Mar 2026

Nuclear speckles may be the unseen architects of viral infection spread

Recent research reveals that nuclear speckles play a key role in modifying viral messenger RNAs and in their transport out of the nucleus; therefore, nuclear speckles are an important subject of study in understanding viral infections.

17 Feb 2026

Herpes virus infection softens cell nuclei through internal mechanical changes

A recent international research project has used advanced microscopy techniques and computational modeling to discover why virus infection changes the nuclear structures and biomechanical forces affecting the nucleus.

3 Feb 2026

Study clarifies role of steroids in treating HSV encephalitis

A major UK clinical trial has shown that adding the corticosteroid dexamethasone to standard antiviral treatment for encephalitis (brain inflammation), caused by herpes simplex virus (HSV) does not improve long-term outcomes overall, although early use may lead to better recovery, and the treatment is safe for patients in whom encephalitis is suspected.

21 Jan 2026

Scientists capture real-time action of antiviral drugs on herpes

Harvard Medical School researchers have uncovered crucial insights into how an emerging class of antiviral drugs works.

30 Dec 2025

Hyperphosphorylated tau may help protect the brain from infection

One of the main proteins that contributes to Alzheimer's disease is called phospho-tau (p-tau). When p-tau gets too many phosphate groups attached to it (a process called hyperphosphorylation), it starts to stick together and form clumps called "tangles" inside of brain nerve cells.

17 Dec 2025

Engineered herpes virus activates potent immune responses against glioblastoma

Researchers at Mass General Brigham have modified a herpes simplex virus (HSV-1) that stimulates the immune system to attack glioblastoma cells.

4 Dec 2025

Nasal vaccine shows promise as a non-invasive treatment for cervical cancer

Cervical cancer, which affects the reproductive tract, is one of the most common cancers in women worldwide.

12 Nov 2025

Pin1 inhibitors could reduce or stop outbreaks of herpes simplex virus 1

A class of antivirals called Pin1 inhibitors could reduce or stop outbreaks of herpes simplex virus 1 (HSV-1), the common infection behind oral herpes, according to new research published in Antiviral Research on July 25.

17 Oct 2025

Nasal spray of gold nanoparticles delivers lithium directly to the brain

In the form of a 'nasal spray', tiny gold particles act as carriers, delivering a treatment directly to the brain: developed by scientists at the Università Cattolica Rome campus/Fondazione Policlinico Universitario A. Gemelli IRCCS, a new nanotechnological device for the treatment and prevention of neuropsychiatric and neurodegenerative diseases.

8 Oct 2025

Discovery reveals hidden differences in herpes virus cultures

Matthew Taylor likened his recently published work alongside doctoral student Gary Dunn to kicking over a rock. Once the discovery was made, it was time to see what lay beneath.

3 Oct 2025

Do tongue piercings harm your oral health? Evidence points to yes

Researchers reviewed 19 studies on tongue piercings and found they carry significant oral health risks, including fractures, gum recession, infections, and rare systemic complications. The evidence base is limited but highlights the need for clinician vigilance and patient awareness.

21 Sep 2025