Hyperandrogenism News and Research

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PMOS rethink reframes a common hormone disorder as a whole-body disease

A new review reframes PCOS, now proposed as PMOS, as a systemic endocrine and metabolic disorder shaped by genetic, epigenetic, ovarian, metabolic, and neuroendocrine pathways. It highlights why inconsistent diagnosis and symptom-focused care have limited progress, while targeted therapies, biomarkers, machine learning, and organ-on-chip models may support more personalized treatment.

18 Jun 2026

Postbiotics may help treat PCOS by restoring microbiome balance

Emerging studies suggest postbiotics could aid PCOS management by restoring gut microbiome balance and enhancing insulin sensitivity and hormonal regulation.

10 Mar 2026

Can ketogenic diets help PCOS? New analysis points to weight and insulin gains

A systematic review and meta-analysis of 15 studies found that ketogenic diets were associated with short-term reductions in body weight, waist circumference, insulin resistance, and some reproductive hormones in women with polycystic ovary syndrome, primarily among those with overweight or obesity. However, substantial heterogeneity, low certainty of evidence, limited safety reporting, and short follow-up periods mean the clinical effectiveness and long-term sustainability of ketogenic diets in PCOS remain uncertain.

5 Jan 2026

How Traditional Chinese Medicine may reshape the gut microbiome to ease insulin resistance in PCOS

This review synthesizes evidence that gut microbiota dysbiosis contributes to insulin resistance and symptom severity in polycystic ovary syndrome through impaired barrier function, inflammation, and altered microbial metabolites. It evaluates how Traditional Chinese Medicine may modulate these pathways while highlighting major gaps in clinical validation, safety, and standardization.

16 Dec 2025

Study shows how ketogenic eating improves hormonal balance in PCOS

The very low-carbohydrate ketogenic diet leads to meaningful reductions in weight, visceral adiposity, insulin resistance, and androgen excess in women with PCOS based on pooled randomized trials. Benefits appear consistent across studies, though high heterogeneity, short durations, and limited safety data highlight the need for longer-term comparative research.

19 Nov 2025

Myo-inositol fails to lower pregnancy risks in women with PCOS

Myo-inositol supplementation shows no significant benefits in preventing pregnancy complications for women with PCOS, according to a recent large-scale study.

30 Sep 2025

Are you at risk? Waist size, not weight, could affect fertility in women

Researchers found that higher relative fat mass (RFM), a measure of visceral body fat, is significantly associated with increased infertility risk in U.S. women aged 20–44. The study suggests RFM may be a more sensitive screening tool for infertility risk than traditional BMI, especially in women with normal weight but high visceral fat.

3 Jul 2025