Large Intestine News and Research

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IBD patients with family cancer history more likely to develop colorectal cancer

People with inflammatory bowel disease (IBD) who have several close relatives with colorectal cancer are significantly more likely to develop the disease themselves.

3 Sep 2026

AI reveals effective combination therapy for advanced rectal cancer

Artificial intelligence developed by researchers at UCL has revealed a promising combination of cancer treatments that could help patients with locally advanced rectal cancer live longer.

27 Jul 2026

Could your birth characteristics influence colorectal cancer risk?

A California study links birth and parental factors to early-onset colorectal cancer risk, highlighting male sex and Hispanic ethnicity as key contributors.

26 Jun 2026

Plant-based quinoa burgers reduce post-meal blood sugar spikes

A study reveals that plant-based burgers with baru pulp and red quinoa trigger lower blood sugar spikes than glucose, highlighting their potential in nutrition.

10 Jun 2026

Gut changes linger years after polyp removal and may signal colorectal cancer risk

Researchers found that women who had undergone colorectal adenoma resection still showed gut microbiome and fecal metabolome alterations an average of about 12 years later. These persistent changes partly resembled colorectal cancer-associated patterns, suggesting that the host-microbiome axis may remain altered along the adenoma-cancer continuum.

28 May 2026

Using AI to improve success rates of fecal microbiota transplants

MOZAIC leverages deep learning to optimize fecal microbiota transplantation, enhancing treatment efficacy through precise donor-recipient microbiome matching.

12 May 2026

Pathogens drive inflammation by reprogramming host cell metabolic processes

An intestinal pathogen reshapes the gut environment to fuel its own colonization and cause diseases, a multi-institutional team including researchers at Vanderbilt Health has discovered.

30 Apr 2026

Study links common herbicide to rising early-onset colorectal cancer risk

Researchers used DNA methylation-based “epigenetic fingerprints” as proxies for lifelong exposome-related patterns and found that early-onset colorectal cancer was associated with lower Mediterranean diet adherence, lower education, smoking-related signatures, and higher picloram-related exposure signals. They then supported the picloram association in nine independent cohorts and with 21 years of US county-level pesticide-use data, while noting that the findings show association rather than proof of causation.

22 Apr 2026

Gut microbiota regulates intestinal epithelial cell function and plasticity

A research team led by scientists from the State University of Campinas (UNICAMP) in São Paulo, Brazil, has made significant progress in understanding the relationship between gut microbiota and intestinal cells.

7 Apr 2026

Study reveals bacterial duo driving chronic constipation

Scientists at Nagoya University in Japan have found two gut bacteria working together that contribute to chronic constipation.

19 Feb 2026

New genetic model reveals role of keratin 8 in colorectal cancer development

Researchers at Åbo Akademi University have identified a new molecular change in patients with colorectal cancer and developed a genetic disease model that forms tumors in the large intestine, resembling those seen in patients.

10 Feb 2026

Obesity study reveals gut fat's unique inflammatory role and immune cell richness

Abdominal fat is not a uniform tissue. A new study from Karolinska Institutet, Steno Diabetes Center Copenhagen, and Helmholtz Munich reveals that fat located close to the large intestine contains an unusually high number of inflammatory fat cells and immune cells.

13 Jan 2026

DNA analysis of colorectal polyps improves diagnosis and treatment

In about 5–10% of colorectal cancer patients, hereditary factors play a role, with higher percentages among younger patients.

12 Jan 2026

Advances in delivering oxygen-sensitive gut bacteria improve microbial therapies

Recent research has identified practical ways to protect and deliver oxygen-sensitive gut bacteria for a path toward safer, standardized microbial therapies that could reduce reliance on donor-based faecal microbiota transplants.

15 Dec 2025

Integrating AI into colon cancer diagnosis improves the speed and accuracy of detection

A recent study reveals that integrating Artificial Intelligence (AI) into colon cancer diagnosis over the past five years has significantly improved the speed and accuracy of the detection of the deadly disease.

8 Dec 2025

Oral microsphere pills can detect markers of gastrointestinal disease

Move over, colonoscopies - researchers report in ACS Sensors that they've developed a sensor made of tiny microspheres packed with blood-sensing bacteria that detect markers of gastrointestinal disease.

19 Nov 2025

Mathematical models explain food movement and churning in the digestive tract

Synchronization abounds in nature: from the flashing lights of fireflies to the movement of fish wriggling through the ocean, biological systems are often in rhythmic movement with each other.

31 Oct 2025

Study: Not all dietary proteins are digested equally in the gut

As protein-rich diets become increasingly popular, a new study suggests that categorizing dietary proteins as either animal- or plant-based fails to effectively capture the source-specific differences in their composition, digestive efficiency and accessibility to the gut microbiota.

4 Sep 2025

Researchers discover why smoking tobacco helps people with ulcerative colitis

Researchers led by Hiroshi Ohno at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have discovered why smoking tobacco helps people suffering from ulcerative colitis, a chronic disease typified by inflammation of the large intestine.

25 Aug 2025

New research reveals why fiber-rich diets fuel you better than refined foods

This study quantifies how much energy the human body harvests from gut microbial fermentation of dietary fiber, integrating bacterial physiology, diet, and metagenomic data. Results reveal that dietary fiber, not microbiome composition, mainly determines the amount of short-chain fatty acids absorbed, impacting daily energy and metabolic health.

31 Jul 2025