Metabolome News and Research

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The obesity-microbiome story is more complicated than ‘good’ and ‘bad’ bacteria

This review finds that obesity is linked to reciprocal interactions between diet, the gut microbiome, microbial metabolites, and host metabolic pathways that influence appetite, insulin sensitivity, inflammation, and energy balance across the lifespan. It highlights diet as a particularly tractable way to influence this system, while emphasizing that microbiome changes associated with GLP-1 therapies remain difficult to separate from weight loss and that functional multi-omics approaches may help enable more personalized interventions.

3 Sep 2026

Sprint exercise sends a very different molecular signal through the body

Sprint-interval exercise triggers a much larger and faster shift in circulating proteins and metabolites than moderate-intensity exercise, revealing distinct patterns of predicted communication between organs. The findings suggest that exercise intensity shapes systemic molecular signaling, with skeletal muscle and adipose tissue emerging as potential source and target tissues linked to cardiometabolic health.

16 Aug 2026

Biognosys showcases next-gen multiomics innovations at ASMS 2026

The Biognosys Group, a leader in mass spectrometry-based multiomics, announces advancements across its integrated multiomics portfolio, highlighting next-generation software, sample preparation, enrichment, and separation technologies for proteomics and metabolomics.

From Biognosys 26 Jun 2026

AI and multiomics reveal how gut bacteria trigger colon cancer

Over the past two decades, high‑throughput sequencing has dramatically expanded our understanding of the gut microbiome's composition.

26 Jun 2026

Scientists map blood chemistry links to hundreds of diseases

A UK Biobank study of nearly 390,000 people mapped 251 NMR-derived plasma metabolic traits against hundreds of health traits, prevalent diseases, and future disease outcomes. The atlas revealed tens of thousands of replicated associations, showed stronger prediction for selected short-term and cardiometabolic outcomes, and identified putative causal links that may guide future precision medicine research.

24 Jun 2026

Microbially modified bile acids influence sleep apnea outcomes

Studies in mice reveal a new target for potentially treating and preventing life-threatening cardiovascular complications in the millions of patients with sleep apnea worldwide.

7 Jun 2026

Gut changes linger years after polyp removal and may signal colorectal cancer risk

Researchers found that women who had undergone colorectal adenoma resection still showed gut microbiome and fecal metabolome alterations an average of about 12 years later. These persistent changes partly resembled colorectal cancer-associated patterns, suggesting that the host-microbiome axis may remain altered along the adenoma-cancer continuum.

28 May 2026

Persistent gut microbiome changes linked to sustained colorectal cancer risk

More than a decade after removal of an adenoma-a precancerous mass-from the colon, alterations to the gut microbiome and metabolites remain and may drive heightened risk of colorectal cancer (CRC), according to a new study led by researchers at Harvard T.H. Chan School of Public Health.

27 May 2026

Retatrutide reshapes metabolism in obesity and type 2 diabetes, study finds

Retatrutide altered circulating metabolites and lipids linked to fatty acid oxidation and insulin resistance in people with obesity, with or without type 2 diabetes. These biomarker changes suggest improved metabolic health, but the post-hoc analysis remains hypothesis-generating and does not prove direct clinical benefit.

26 May 2026

Tomato-soy juice curbs inflammation in obese adults

Drinking tomato-soy juice loaded with compounds shown in animal studies to promote health lowered pro-inflammatory proteins in healthy adults with obesity after four weeks, a new study found.

26 May 2026

Blood metabolite patterns could reveal dementia risk in midlife

Research shows that blood metabolite profiles can indicate dementia risk, offering a potential tool for early detection and prevention of cognitive decline.

18 May 2026

Faster biological aging linked to higher dementia risk

Having a biological age older than chronological age is associated with a greater likelihood of developing dementia, a new study has shown.

13 May 2026

Study identifies new genetic pathways driving cardiometabolic disease risk

A study published today in PLOS Medicine has identified two new genetic pathways that contribute to cardiometabolic disease, which includes heart disease, obesity and diabetes.

23 Apr 2026

Newborns carry antibiotic resistance genes within first hours of life

Antibiotic resistance genes (ARGs) – segments of DNA that help bacteria survive the effects of antibiotics – can be present in newborns within the first hours of life, according to research presented at ESCMID Global 2026.

20 Apr 2026

Higher stress and BMI tied to earlier puberty in girls

New research links stress, BMI, and hormone patterns to pubertal timing, revealing implications for long-term health and early intervention strategies.

16 Apr 2026

Steroid hormones, BMI and stress influence puberty timing in girls

Higher levels of key steroid hormones-combined with elevated stress and body mass index (BMI)-are associated with earlier onset of puberty in girls, according to a new study at Columbia University Mailman School of Public Health.

13 Apr 2026

Sleep and diet emerge as key drivers of immunome variation

Immunome (immune cells and functions) variations are closely related to human health. Various exposures, including the external environment and personal lifestyles, are important factors affecting the immune system.

9 Mar 2026

Why promising microbiome therapies rarely work in patients

Addressing the microbiome's translational gap involves understanding biological complexity and developing function-driven, patient-specific interventions.

8 Jan 2026

The gut is not just digestive and new evidence shows it actively controls brain function

This comprehensive review synthesizes a decade of human and animal research to explain how the gut and brain communicate through hormonal, neural, immune, and microbial pathways. It highlights how disruptions in these pathways contribute to gastrointestinal, metabolic, and neurological disorders, and how modern therapies are beginning to exploit gut–brain signaling for clinical benefit.

6 Jan 2026

Sweat testing could transform drug monitoring and diabetes care

Innovative sweat sampling techniques could revolutionize diagnostics, offering insights into glucose levels and environmental toxins with minimal discomfort.

4 Dec 2025