Oncogenesis News and Research

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New studies reveal hidden control hub for MYC-driven cancers

In a rare pair of papers published back-to-back in the journal Genes & Development, research teams led by senior author Anindya Bagchi, PhD, associate professor in the Cancer Genome and Epigenetics Program at Sanford Burnham Prebys Medical Discovery Institute, establish a unified framework that governs one of cancer's most powerful master regulators.

19 Aug 2026

Study links dietary fructose to aggressive spread of ovarian cancer

A new study from The Wistar Institute has uncovered an unexpected link between fructose - a common dietary sugar - and the spread of an aggressive form of ovarian cancer.

30 Jul 2026

New mechanism behind chemotherapy resistance in ovarian cancer discovered

Scientists at The Wistar Institute have identified a new mechanism behind the chemotherapy resistance that makes ovarian cancer so lethal.

23 Jul 2026

Review explores complex associations between sleep apnea and lung cancer

Obstructive sleep apnea (OSA) is a common sleep disorder characterized by intermittent hypoxia and sleep fragmentation, which may contribute to lung cancer development and progression.

29 May 2026

Naturally occurring peptide can reverse drug resistance in melanoma

Melanoma is one of the deadliest forms of skin cancer, due in large part to its ability to rapidly develop resistance to treatment.

27 May 2026

Targeted therapy treats mixed histiocytosis following multiple skull relapses

Mixed histiocytosis (Langerhans cell histiocytosis [LCH] / Erdheim-Chester disease [ECD]) developing after treatment for initial skull LCH is not well recognized.

13 Apr 2026

Targeting super-enhancer mechanisms offers new strategies for cancer therapy

Super-enhancers (SEs) are large clusters of transcriptional regulatory elements that drive oncogene expression, maintain malignancy, and create "transcriptional addiction" in cancer.

13 Apr 2026

Nanomedicine offers targeted solutions for breast cancer treatment

Breast cancer (BCA) is one of the most common cancers worldwide, with high mortality and morbidity in women.

10 Apr 2026

New PCR method enables full genome amplification of HPV16

Human papillomavirus (HPV) is a double-stranded circular DNA virus with a genome of approximately 7–8 kb. This study aimed to establish an overlapping extension polymerase chain reaction method for the amplification of the entire genome of HPV16.

10 Apr 2026

New blood test spots four cancers and other diseases by stripping away healthy DNA noise

MethylScan is a new low-cost cell-free DNA methylome test that removes much of the healthy blood DNA background, helping rare disease signals stand out more clearly. In more than 1,000 people, it showed strong performance for detecting four cancers, classifying liver diseases, and identifying organ-specific damage.

7 Apr 2026

Tumor-targeted chimeric drug increases efficacy and limits side effects

Wistar scientists have combined a promising cancer therapy with a molecule that targets tumors to treat cancer more effectively.

7 Feb 2026

New CPRIT awards expand cancer prevention and treatment research in South Texas

UT Health San Antonio, the academic health center of The University of Texas at San Antonio (UT San Antonio), received nearly $3 million in new academic and prevention awards as part of the latest funding round announced by the Cancer Prevention Research Institute of Texas (CPRIT).

19 Dec 2025

Lactate and lactylation drive metabolic, epigenetic reprogramming in gynecological cancers

Lactate, once considered a metabolic waste product, is now recognized as a key regulator of cellular homeostasis and disease progression.

31 Oct 2025

Bowhead whale’s secret to long life revealed: precision DNA repair may hold clues for human aging

Researchers discovered that bowhead whales achieve extraordinary longevity and cancer resistance through highly efficient and precise DNA repair mechanisms. A whale-specific protein, CIRBP, enhances genome stability even in human cells, revealing a potential pathway to strengthen DNA repair and slow aging.

30 Oct 2025

Advances in diagnosis and management of systemic light chain amyloidosis

Systemic light chain (AL) amyloidosis is a rare and life-threatening disorder characterized by the deposition of misfolded immunoglobulin light chains as insoluble amyloid fibrils in various tissues and organs, leading to progressive structural and functional impairment.

30 Oct 2025

Therapeutic potential of Scleromitrion diffusum in gastric cancer treatment

Gastric cancer remains a major global health challenge, characterized by high mortality and limited therapeutic efficacy, especially in advanced stages.

30 Oct 2025

Fundamental challenges and cutting-edge strategies in developing new GBM CAR-T therapies

Glioblastoma (GBM), the most aggressive primary brain tumor, continues to portend a poor prognosis with median survival under two years, despite standard care involving surgery, radiation, and temozolomide chemotherapy.

30 Oct 2025

AI indelibly transforms solid tumor drug development

Artificial intelligence (AI) is fundamentally reshaping the landscape of solid tumor (ST) drug development.

29 Oct 2025

First clinical trial in cats tests targeted therapy for deadly head and neck cancer

Researchers have reported results from the first-ever clinical trial of a new class of targeted therapy in pet cats with head and neck squamous cell carcinoma (HNSCC)-a cancer which is notoriously deadly and difficult to treat.

28 Aug 2025

Dementia-like protein clumping found in early pancreatic cancer cells

Cancer Research UK-funded scientists have uncovered dementia-like behaviour in pancreas cells at risk of turning into cancer. The findings provide clues that could help in the treatment and prevention of pancreatic cancer, a difficult-to-treat disease linked to 6,900 deaths in the UK every year.

17 Aug 2025