Paraplegia News and Research

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Paraplegia is an impairment in motor or sensory function of the lower extremities. It is usually the result of spinal cord injury or a congenital condition such as spina bifida which affects the neural elements of the spinal canal.

Primate-specific DNA change reveals a new link to dementia-related neurodegeneration

Brain diseases, including dementia, have long been studied using experimental animals such as mice. However, differences between the human and animal genomes have raised concerns that some disease mechanisms may not be fully explained by conventional animal models.

29 Aug 2026

Brain organoids reveal how Alu-mediated gene deletion can lead to neurodegeneration

Brain diseases, including dementia, have long been studied using experimental animals such as mice.

27 Aug 2026

Novel interventional approach successfully treats rare hepatic myelopathy

Hepatic myelopathy (HM) is a rare neurological complication of decompensated chronic liver disease that profoundly impairs quality of life.

28 Jul 2026

Walking protein structure explains how cells activate molecular motors

A nerve cell resembles a vast tree with branches that communicate with thousands of other cells. To function, it depends on a motor protein that walks on two legs, hauling urgent cargo from the center of the cell to the faraway tips of every branch.

15 Jul 2026

New antibody therapy promotes nerve regeneration after spinal cord injury

An international research group recently demonstrated that the antibody NG101 promotes the regeneration of damaged spinal cord tissue.

12 May 2026

Researchers identify CD99L2 gene as a cause of spastic ataxia

Despite modern high-throughput sequencing, the genetic cause of most rare movement disorders remains unclear.

17 Mar 2026

Boston Children's Hospital secures $8.1M for spastic paraplegia research

Boston Children's Hospital has received $8.1M in NIH funding to support and expand the Spastic Paraplegia Centers of Excellence Research Network (SP-CERN). Darius Ebrahimi-Fakhari, M.D., Ph.D., Director of the Movement Disorders Program at Boston Children's, and his team will lead this multi-center effort.

24 Oct 2025

Brain cells can burn fat to fuel activity

While glucose, or sugar, is a well-known fuel for the brain, Weill Cornell Medicine researchers have demonstrated that electrical activity in synapses—the junctions between neurons where communication occurs—can lead to the use of lipid or fat droplets as an energy source.

1 Jul 2025

Mouse study confirms early inflammation in hereditary paralysis condition

A joint study conducted by the University of Bonn and the DZNE has confirmed early-stage brain inflammation in mice.

25 Apr 2025

Advances and challenges in brain implant technology

In a paper recently published in the leading journal "The Lancet Digital Health", a scientific team led by Stanisa Raspopovic from MedUni Vienna looks at the progress and challenges in the research and development of brain implants.

24 Jan 2025

Nogo-A inhibition demonstrates potential for spinal cord injury recovery

The latest study results have been published online in the renowned "The Lancet Neurology" journal. A multi-centre clinical trial (NISCI trial: Nogo-A Inhibition in acute Spinal Cord Injury Study) investigated the antibody NG 101 (anti-Nogo-A), which blocks and thus neutralizes the body's own Nogo-A protein.

19 Dec 2024

Gene therapy milestone at SickKids offers hope for children with SPG50 neurodegenerative disorder

When Michael Pirovolakis received an individualized gene therapy in a single-patient clinical trial at The Hospital for Sick Children (SickKids) in March 2022, the course of his condition was dramatically altered.

28 Jun 2024

Genes affecting worm behavior found to be relevant to neurological disease in humans

As an undergraduate student in The University of Texas at Arlington's Honors College, Hannah Selvarathinam knew she wanted to conduct research. Near the end of her first year at UTA, the Keller native reached out to the lab of biology Assistant Professor Piya Ghose.

30 Apr 2024

SPG-15: A Mother's Fight for a Gene Therapy Cure, Maddi's Story

News Medical spoke to the CEO and founder of the Maddi Foundation to gain a patient perspective on how important research in gene therapy is.

3 Jul 2023

Revolution in neuroscience: 2D nanomaterials propel advances in brain repair, treatment, and diagnosis

Review discusses the increasing importance of two-dimensional nanomaterials like graphene in neuroscience, highlighting their potential in nerve repair, creating brain-mimicking synaptic devices, and treating neurological disorders. It also considers the challenges and future prospects of these materials in this complex field.

11 Jun 2023

Paraplegia News and Research

Further Reading

Primate-specific DNA change reveals a new link to dementia-related neurodegeneration

Brain organoids reveal how Alu-mediated gene deletion can lead to neurodegeneration

Novel interventional approach successfully treats rare hepatic myelopathy

Walking protein structure explains how cells activate molecular motors

New antibody therapy promotes nerve regeneration after spinal cord injury

Researchers identify CD99L2 gene as a cause of spastic ataxia

Boston Children's Hospital secures $8.1M for spastic paraplegia research

Brain cells can burn fat to fuel activity

Mouse study confirms early inflammation in hereditary paralysis condition

Advances and challenges in brain implant technology

Nogo-A inhibition demonstrates potential for spinal cord injury recovery

Gene therapy milestone at SickKids offers hope for children with SPG50 neurodegenerative disorder

Genes affecting worm behavior found to be relevant to neurological disease in humans

SPG-15: A Mother's Fight for a Gene Therapy Cure, Maddi's Story

Revolution in neuroscience: 2D nanomaterials propel advances in brain repair, treatment, and diagnosis

Using brain organoids to test gene therapies for a rare disease in children

Researchers discover a new role for one of the genes linked to hereditary spastic paraplegia

Research shows the role of PCYT2-mediated lipid synthesis in vertebrate muscle health

New research model enables scientists to test therapeutics for rare neurodegenerative diseases

Genetic discovery may pave the way to new diagnostic approaches, treatments for motor neurone diseases

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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