Prion News and Research

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Study confirms strong barrier preventing chronic wasting disease transmission to humans

A new study of prion diseases, using a human cerebral organoid model, suggests there is a substantial species barrier preventing transmission of chronic wasting disease (CWD) from cervids-;deer, elk and moose-;to people.

17 May 2024

Boosting mitochondrial health can reverse protein clumping in aging and Alzheimer's

It has long been known that a hallmark of Alzheimer's disease, and most other neurodegenerative diseases, is the clumping together of insoluble protein aggregates in the brain.

16 May 2024

Novel gene-delivery vehicle shows promise for treating brain disorders

In an important step toward more effective gene therapies for brain diseases, researchers from the Broad Institute of MIT and Harvard have engineered a gene-delivery vehicle that uses a human protein to efficiently cross the blood-brain barrier and deliver a disease-relevant gene to the brain in mice expressing the human protein.

16 May 2024

Repurposing human-approved drugs for prion disease treatment

Prions are the abnormal, pathogenic agents that are transmissible and are able to induce abnormal folding of specific normal cellular proteins.

16 May 2024

Study identifies a new biomarker for Alzheimer's disease in asymptomatic stages

A recent study led by the Molecular and Cellular Neurobiotechnology group at the Institute for Bioengineering of Catalonia (IBEC) and the University of Barcelona has identified a new biomarker for Alzheimer's disease in asymptomatic stages of the disease.

15 May 2024

Possibility of wildlife-to-human crossover heightens concern about chronic wasting disease

Each fall, millions of hunters across North America make their way into forests and grasslands to kill deer. Over the winter, people chow down on the venison steaks, sausage, and burgers made from the animals.

2 Feb 2024

Cadaveric pituitary-derived growth hormone delivery influences iatrogenic Alzheimer’s Disease

Recipients of cadaver-derived pituitary growth hormone (c-hGH) developed biomarker changes in the realm of Alzheimer’s disease (AD).

31 Jan 2024

New insights into the interplay between prions and TDP-43 in neurodegenerative pathology

Neurodegenerative diseases are characterized by the deposition of clumped proteins in the brain and progressive neuronal cell death.

4 Dec 2023

Ticks could be a new vector for chronic wasting disease

A new study from researchers at the University of Wisconsin–Madison finds that ticks can harbor transmissible amounts of the protein particle that causes Chronic Wasting Disease (CWD), implicating the parasites as possible agents in the disease's spread between deer in Wisconsin. Her findings were published in the journal Nature.

7 Jul 2023

Ticks found to harbor and release prions of chronic wasting disease

Researchers determined whether ticks contain transmission-relevant amounts of chronic wasting disease.

17 May 2023

NQO2 gene as a novel potential target in Parkinson’s disease

A new study under review at the journal Scientific Reports and currently available on the Research Square* preprint server aimed to analyze the toxic effects of 6OHDA along with a related role of NQO2 in murine and human astrocytes.

23 Feb 2023

Researchers provide a framework for unifying and categorizing neurodegenerative diseases based on eight hallmarks

Researchers presented eight hallmarks of neurodegenerative diseases (NDDs), their in vivo biomarkers, and interactions to help categorize NDDs and specify patients within a specific NDD.

21 Feb 2023

Could trained scent-detection dogs be used for chronic wasting disease surveillance?

A recent study published in Prion investigated whether trained scent-detection dogs could be used for chronic wasting disease (CWD) surveillance.

13 Feb 2023

Study reveals sex differences in response to drugs targeting tauopathies

Microglia are cells that are central to both brain health as well as disease progression in many neurological conditions.

24 Jan 2023

Novel prion strain causes chronic wasting disease in a Finland moose

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19 Jan 2023

Research findings may offer a new potential therapeutic target for Alzheimer’s disease

A new study links a gene concentrated in the brain's cleanup cells, known as microglia, to the inflammation that has increasingly emerged as a key mechanism contributing to Alzheimer's disease.

30 Nov 2022

Brain changes can be studied in very early stages of neurodegenerative diseases

Many changes take place in the brain long before symptoms appear. This has been shown in mice in two studies of prion diseases in which the brain gradually deteriorates.

10 Oct 2022

NPDPSC at Case Western Reserve University to receive CDC funding for better understanding of prion diseases

The National Prion Disease Pathology Surveillance Center at Case Western Reserve University will receive up to $20 million in funding as part of a grant renewal from the Centers for Disease Control and Prevention (CDC) to better understand how and why prion diseases––degenerative brain conditions found in both humans and animals-;develop and spread.

20 Sep 2022

Study investigates link between plasma miRNAs and cognitive function among cognitively normal men

A new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by Medline/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 17, entitled, "Extracellular microRNA and cognitive function in a prospective cohort of older men: The Veterans Affairs Normative Aging Study."

15 Sep 2022

Exercise hormone irisin blocks Parkinson's-associated α-synuclein aggregation and related neuronal toxicity

A new paper discusses the hope held out by recent results on a compound called irisin, a short protein secreted by skeletal muscle that produces some exercise-related effects on the brain.

15 Sep 2022

Prion News and Research

Study confirms strong barrier preventing chronic wasting disease transmission to humans

Boosting mitochondrial health can reverse protein clumping in aging and Alzheimer's

Novel gene-delivery vehicle shows promise for treating brain disorders

Repurposing human-approved drugs for prion disease treatment

Study identifies a new biomarker for Alzheimer's disease in asymptomatic stages

Possibility of wildlife-to-human crossover heightens concern about chronic wasting disease

Cadaveric pituitary-derived growth hormone delivery influences iatrogenic Alzheimer’s Disease

New insights into the interplay between prions and TDP-43 in neurodegenerative pathology

Ticks could be a new vector for chronic wasting disease

Ticks found to harbor and release prions of chronic wasting disease

NQO2 gene as a novel potential target in Parkinson’s disease

Researchers provide a framework for unifying and categorizing neurodegenerative diseases based on eight hallmarks

Could trained scent-detection dogs be used for chronic wasting disease surveillance?

Study reveals sex differences in response to drugs targeting tauopathies

Novel prion strain causes chronic wasting disease in a Finland moose

Research findings may offer a new potential therapeutic target for Alzheimer’s disease

Brain changes can be studied in very early stages of neurodegenerative diseases

NPDPSC at Case Western Reserve University to receive CDC funding for better understanding of prion diseases

Study investigates link between plasma miRNAs and cognitive function among cognitively normal men

Exercise hormone irisin blocks Parkinson's-associated α-synuclein aggregation and related neuronal toxicity

Microbiology eBook

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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