Genizer’s NanoGenizer-30K is an electric benchtop, laboratory-scale, high-pressure homogenizer developed specifically for bacterial and cell lysis (including yeasts and E. coli).
It supports laboratory research and development as well as small-scale production at ultra-high pressure (maximum pressure of 45,000 psi/3000 bar), and does not require hydraulic oil or compressed air. It is offered in both 3D-printing and stainless versions.
NanoGenizer High-Pressure Homogenizer, Plug & Play, for cell disruptions. Image Credit: Genizer LLC
Main Features of the NanoGenizer
- Flow rate (water value): approximately 100 mL/minute at 30,000 psi
- Diamond interaction chamber (electropolishing and passivation available for pharmaceutical applications)
- Weight: approximately 35 kg
- Pressure: 25,000 psi, 30,000 psi, and 45,000 psi
- Precision sampling with accuracy up to 0.1 mL resolution
- Minimum sample volume: five mL
- Applications: nanoemulsions, fat emulsions, liposomes, cell disruption, nanodispersion, deagglomeration, graphene, and carbon nanotubes
The diamond interaction chamber is a key component of the NanoGenizer high-pressure homogenizer. It leverages microfluidic technology, and its interior is equipped with nanoscale microchannels. Within this environment, the formulation is subjected to forces of intense impact and high shear, resulting in nano cell disruption and nanoparticle dispersion.
After being pressurized and accelerated by the intensifier, the sample’s micro-jet can reach speeds of up to 1000 m/second, exceeding the speed of sound (340 m/second). When the high-velocity, projectile-like micro-jet passes through the microchannels of the diamond interaction chamber, it undergoes complex physical phenomena, including high-energy impact, high-frequency shear, cavitation, and pressure reduction. As a result, the material becomes nanosized and homogenized.
Genizer diamond interaction chamber with cooling, F12Y-RT. Image Credit: Genizer LLC
Nano Emulsion, Liposome, NanoCosmetic, Nanomaterial. Image Credit: Genizer LLC
Compared to the conventional homogenizing valve, the Genizer diamond interaction chamber contains no moving components within the chamber. This ensures consistent results across different batches.
It can also be widely applied in the biochemical, pharmaceutical, cosmetics, food, and dairy industries, among others. In addition, it supports experimentation ranging from particle size reduction to cell disruption, nanoemulsions, nanodispersions, liposomes, and more.
Enhanced features
- Glass and 316 L stainless steel feed reservoir are available as options
- One-year warranty against any manufacturing defects
- Cooling system: the heat exchanger and the diamond interaction chamber are designed with cooling ports
- Control system: PLC touchscreen, auto-stop on passes, digital pressure display, and volume
- Equipped with a ceramic plunger
- Tools and spare parts
- Compliant with CE and RoHS