In liposome extrusion processes, flow rate increases with the membrane’s surface area. A pilot-scale liposome extrusion system is the GOE-142MM, which uses large polycarbonate filter membranes, around 142 mm in diameter, which improve extrusion performance and enable a high flow rate.
Genizer GOE-142MM, Online Liposome Extruder. Image Credit: Genizer LLC
Liposome with PEGylated Lipids. Image Credit: Genizer LLC
The Genizer Online Extruder (GOE-142MM) is paired with a microfluidic homogenizer, such as the NanoGenizer or HandGenizer. When the GOE-142MM is used in conjunction with the NanoGenizer homogenizer, researchers can reduce the number of passes needed to achieve a perfect liposome size distribution and desired particle sizes because the NanoGenizer system's diamond interaction chamber helps pre-treat the liposome sample to the nanoscale.
NanoGenizer with GOE-142MM Liposome Extruder. Image Credit: Genizer LLC
Features
- Spares: O-rings, collection silicone tubing
- Other Applications: large pore support screen, laser micro pore disc
- Capacity: 3000 mL
- Filter diameter: 142 mm
- Cooling: Jacketed cooling ports
- Material: 316L stainless steel, NBR, or Viton