Liposomes have emerged as a significant biomedical carrier system. Particle size is one of the most important elements impacting the performance of liposomes.
High-pressure homogenization, extrusion, and sonication are all strategies for lowering liposome size. Extrusion is a very simple and rapid process.
The Genizer Jacketed Liposome Extruder uses a nitrogen gas cylinder to push a drug, protein, or gene liposome solution through a track-etched membrane with a preset pore size; typically, five– 10 passes are sufficient to produce a sample with uniform liposome size. The Genizer Jacketed Liposome Extruders are intended to create consistent unilamellar liposomes and lipopolyplexes with a low dead volume.
Liposome with double layer of phospholipid molecules. Image Credit: Genizer LLC
Genizer Jacketed Liposome Extruder for Liposome Size Reduction. Image Credit: Genizer LLC
Features
- Material: 316 L stainless steel, NBR, or Viton
- Spares: O-rings, collection silicone tubing
- Additional features: large pore support screen, laser micro pore disc, high pressure nitrogen tubing G5/8
- Capacity level of the extruder barrel: 10 mL/ 100 mL/ 800 mL/ 3000 mL/ 10000 mL
- Filter diameter: 25 mm for GJE10 mL, 47 mm for GJE100 mL, 90 mm for GJE800 mL, 142 mm for GJE3000 mL, 293 mm for GJE-10L
- Cooling: jacketed thermo barrel