Life Science professionals know that the thermodynamic driving forces of macro-molecular interactions are critical parameters for the design of effective biomedical and pharmaceutical treatments. Calorimetry has become the method of choice for characterizing the thermodynamic driving forces of critical molecular interactions and defining molecular stabilities. Calorimetric analyses are based on accurately measuring the rate of heat absorbed or evolved when the biomolecule of interest interacts specifically or nonspecifically with another macromolecule or ligand (binding studies). The TA Instruments Nano ITC Standard Volume or Nano ITC Low Volume instruments are powerful tools to accurately and efficiently perform these important measurements.
The Nano ITC instruments are designed to improve laboratory productivity and efficiency by performing high-sensitivity analyses on nanomolar quantities of biomolecule. This is accomplished through a combination of a high sensitivity calorimeter, accurate and stable temperature control, and efficient titrant delivery
The unique removable syringe assembly contains a mechanical paddle stirrer at the end, the speed of which is easily adjusted to accommodate the physical properties of the sample. The integrated titration assembly of the Nano ITC ensures quick-filling, simple cleaning and accurate titrations. The Nano ITC Standard Volume is available with sample cells made from 99.999 % Gold or Hastelloy C to allow for the widest range of reagent chemistry. The Nano ITC Low Volume is available with sample cell cells made from 99.999 % Gold.
The true isothermal power compensation design and the choice of sample cell volumes of the Nano ITC instruments provides the highest sensitivity and flexibility for an ultrasensitive ITC analyzing biological samples in-solution.