Biochemistry

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Carbohydrate plays important role in regulating blood pressure, research suggests

New research suggests that a particular type of carbohydrate plays an important role in regulating the blood pressure in the human body.

2 Jul 2019

Using popular anticonvulsant drug to thwart inflammation

Serious conditions, including sepsis, stem from inflammation in the body, and there is a lack of effective medication for sepsis.

2 Jul 2019

Study reveals time taken for DNA repair after chemotherapy

In the time it takes for an Amazon Prime delivery to arrive, cells damaged by chemotherapy can almost completely fix their most important DNA. That is the case in the livers of mice at least, according to a new study.

2 Jul 2019

Researchers determine atomic interactions that stabilize phase-changing proteins

Most of the well-studied proteins in our bodies are like metal; some can change shape easily, like aluminum foil, and others are rigid, like steel beams, but they typically have a solid, well-defined structure.

2 Jul 2019

Scientists unravel how cells unfold proteins

A happy cell is a balanced cell, but for every stupendously twisted protein it creates, it must tear the old ones asunder. That means untangling a convoluted pretzel-like mass for recycling. Cdc48 plays a critical role in unraveling the spent proteins.

29 Jun 2019

Artificial DNA can help release active ingredients from drugs in sequence

A drug with three active ingredients that are released in sequence at specific times: Thanks to the work of a team at the Technical University of Munich, what was once a pharmacologist's dream is now much closer to reality.

29 Jun 2019

Study solves mysteries of complex microRNA oncogenes

MicroRNAs are tiny molecules of nucleic acid that control gene expression, acting like a dimmer switch to tone down gene output at key positions in the network of information that governs a cell's function.

28 Jun 2019

Disrupting ChIP Assay Technology with New Advancements

The Chromatrap ChIP technology is a bead-free method of performing ChIP. The potential of the technology emerged from our capabilities in manufacturing porous plastic filters for the filtration and separation of biological materials.

From Chromatrap® - Porvair Sciences Ltd 27 Jun 2019

Compelling New Evidence Further Suggests Parkinson’s Disease Begins in the Gut

A new mouse study has revealed more evidence that Parkinson’s disease originates in the gut before traveling to the brain via the body’s neurons.

27 Jun 2019

A metabolic intermediate in the uronic acid pathway impairs lung cancer metastasis

In a study published online in Nature on June 26, research teams led by Dr. YANG Weiwei at the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences and Dr. LI Guohui from the Dalian Institute of Chemical Physics of CAS reported a new function of uridine diphosphate glucose (UDP-glucose), a metabolic intermediate in the uronic acid pathway: It impairs lung cancer metastasis by accelerating SNAI1 mRNA decay.

27 Jun 2019

Bruker announces novel phenomics solutions at Metabolomics 2019

At Metabolomics 2019, Bruker highlights innovative MS and NMR systems, and novel high-value solutions for molecular phenomics and clinical metabolomics.

From Bruker Life Sciences Mass Spectrometry 26 Jun 2019

Characterizing and Isolating (Bio)macromolecular Structures using MALS

In this interview, Albena Lederer, Head of the Polymer Separation Group at the Leibniz Institute for Polymer Research, talks to News-Medical Life Sciences about the techniques and methods used to understand and analyze polymers.

From Waters | Wyatt Technology 26 Jun 2019

Using Light Scattering to Characterize Protein-Nucleic Acid Interactions

Harnessing the interactions between DNA, RNA, and proteins holds much promise for detecting biomarkers, diagnosing disease, and improving cancer-targeting therapeutics. Quantifying these interactions is essential for understanding and controlling their biomolecular mechanisms.

From Waters | Wyatt Technology 26 Jun 2019

Atomwise and Enamine launch 10 billion compound virtual drug screening initiative

Atomwise, Inc. today announced the launch of a 10 billion compound AI-powered virtual drug screening initiative, the 10-to-the-10 program, in collaboration with Enamine Ltd., the world’s largest chemical supplier.

25 Jun 2019

Engineered cell evolution may provide a path to reduce chemotherapy resistance

A significant problem when treating cancer patients remains drug resistance, which often causes chemotherapy treatments to ultimately fail.

25 Jun 2019

Study sheds light on rhodopsin dynamics in the retina

Photoreceptor cells in our eyes can adjust to both weak and strong light levels, but we still don't know exactly how they do it.

24 Jun 2019

Researchers unlock mystery of immunosuppressive drug's biosynthesis

Mycophenolic acid (MPA), discovered in 1893, was the first natural antibiotic to be isolated and crystallized in human history.

22 Jun 2019

New DNA Microscopy Technique Offers Novel Insight into Genomic Information in Cells

Scientists are now able to see inside cells to a genomic level with a newly invented imaging technique called DNA microscopy. Using DNA “bar codes”, DNA microscopy allows scientists to locate a molecule’s position in a sample without using any kind of optics, meaning genomic information can be collected in large amounts.

21 Jun 2019

McMaster researchers map toxic protein associated with Alzheimer's

A team of researchers from McMaster University has mapped at atomic resolution a toxic protein linked to Alzheimer's disease, allowing them to better understand what is happening deep within the brain during the earliest stages of the disease.

20 Jun 2019

Creating a physical and genetic map of Cannabis sativa

Scientists have developed a physical and genetic map of Cannabis sativa to facilitate further investigation into the genetic and molecular mechanisms exhibited by this plant.

19 Jun 2019