Cell Biology

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Researchers find potential new target for treating systemic inflammation in obesity

A study led by researchers at the University of Chicago and Indiana University has determined that a protein called elF5A is necessary for driving inflammation in macrophage cells in obesity.

7 Sep 2021

Newly identified mechanism can accelerate the development of STING-activating drugs using imaging

A new study from scientists at the UCLA Jonsson Comprehensive Cancer Center found that emerging drugs that activate the protein STING, a well-established regulator of immune cell activation, substantially alter the activity of metabolic pathways responsible for generating the nucleotide building blocks for DNA.

7 Sep 2021

Optimized strategy for generating male germ-cells from mouse pluripotent stem cells

For species that rely on sexual reproduction, including mice and men, offspring can only happen if sperm from the male fertilize eggs from the female.

7 Sep 2021

Research reveals a previously unknown role for a key transcription regulator linked to cancer

CTCF is a transcription factor that has been a research target due to its role in regulating a critical oncogene called MYC.

7 Sep 2021

Study offers important evidence for the safety of stem cell transplants

Stem cell transplants do not lead to changes in the DNA of the donor cells. That's according to a new study, which provides important evidence for the safety of this procedure.

7 Sep 2021

Research uses rodent models to connect the influence of feronomic signals on memory

The work, published recently in Nature Communications, used a model of rodents and managed to connect for the first time the influence of feronomic signals on memory. This will make it possible to explore the deficits of integration of spatial memories and social studies in transgenic models of Alzheimer's disease in the future.

7 Sep 2021

Novel assay helps identify factors that can convert normal cells into liver cancer cells

Researchers at the University of Helsinki could show for the first time that normal human fibroblast cells can be converted to specific cancer cells using only factors that are commonly detected in actual human patients.

7 Sep 2021

Research project focusing on membraneless organelles receives funding from Volkswagen Foundation

As part of its "Life?" project, the Volkswagen Foundation is funding a research project that is placing membraneless organelles within cells in the spotlight as a way of understanding the fundamental processes that are essential to life.

6 Sep 2021

Researchers uncover underlying metabolic changes that are linked to COVID-19 severity

COVID-19 patients have differing immune responses that lead to disease outcomes ranging from asymptomatic SARS-CoV-2 infection to death.

6 Sep 2021

Cancer treatment with terpyridine platinum compounds induces telomere dysfunction, chromosome instability

Oncotarget published "Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells" which reported that this assay is based on the use of two isogenic HT1080 cell lines, one carrying a linear HAC and the other carrying a circular HAC.

6 Sep 2021

Neuroscientists visualize ultrastructural changes to dendritic spines during structural plasticity

Researchers at the Max Planck Florida Institute for Neuroscience have developed a new imaging technique capable of visualizing the dynamically changing structure of dendritic spines with unprecedented resolution.

6 Sep 2021

Researchers develop the smallest CRISPR to date for genome editing

A compact and efficient CRISPR-Cas system, named CasMINI, could be broadly useful for cell-engineering and gene-therapy applications because it is easier to deliver into cells. The findings appear in a study publishing September 3 in the journal Molecular Cell.

4 Sep 2021

Scientists identify a critical checkpoint in transcription elongation

Northwestern Medicine scientists have identified a critical checkpoint in transcription elongation, the process of synthesizing RNA from a DNA template, according to findings published in Molecular Cell.

4 Sep 2021

Study uncovers new mechanism for memory transfer between individual roundworms

When an organism encounters a threat in its environment, it is to the species' advantage to warn others of the peril.

4 Sep 2021

Temperature variations could have driven the division of protocells

A simple mechanism could underlie the growth and self-replication of protocells - putative ancestors of modern living cells - suggests a study publishing September 3 in Biophysical Journal.

4 Sep 2021

Gut microbiome patterns provide clues to brain damage in extremely premature infants

Extremely premature infants are at a high risk for brain damage. Researchers at the University of Vienna and the Medical University of Vienna have now found possible targets for the early treatment of such damage outside the brain: Bacteria in the gut of premature infants may play a key role.

4 Sep 2021

Stem-like T cells within certain lymph nodes could be natural cancer fighters, study shows

In a new study by Yale Cancer Center, researchers show stem-like T cells within certain lymph nodes could be natural cancer fighters.

3 Sep 2021

CAR T cells expressing a natural RNA can activate the body’s own T cells against solid tumors

Chimeric antigen receptor (CAR) T cell therapy, which uses engineered T cells to treat certain types of cancers, has often been a challenging approach to treating solid tumors. CAR T cells need to recognize a specific target on cancer cells to kill them.

2 Sep 2021

New computational approach may predict how individuals are likely to respond to vaccines

In an advance that sheds light on why certain vaccines may influence people differently, a new computational approach developed at the University of Michigan may predict how individual patients are likely to respond.

2 Sep 2021

Cryogenic storage of biological specimens

Ziath, a leading supplier of equipment, software and consumables to simplify your sample management process, offers a range of CryzoTraq™ tubes designed for high integrity cryogenic storage of biological specimens at temperatures down to -196°C.

From Ziath Ltd 2 Sep 2021

Cell Biology

Researchers find potential new target for treating systemic inflammation in obesity

Newly identified mechanism can accelerate the development of STING-activating drugs using imaging

Optimized strategy for generating male germ-cells from mouse pluripotent stem cells

Research reveals a previously unknown role for a key transcription regulator linked to cancer

Study offers important evidence for the safety of stem cell transplants

Research uses rodent models to connect the influence of feronomic signals on memory

Novel assay helps identify factors that can convert normal cells into liver cancer cells

Research project focusing on membraneless organelles receives funding from Volkswagen Foundation

Researchers uncover underlying metabolic changes that are linked to COVID-19 severity

Cancer treatment with terpyridine platinum compounds induces telomere dysfunction, chromosome instability

Neuroscientists visualize ultrastructural changes to dendritic spines during structural plasticity

Researchers develop the smallest CRISPR to date for genome editing

Scientists identify a critical checkpoint in transcription elongation

Study uncovers new mechanism for memory transfer between individual roundworms

Temperature variations could have driven the division of protocells

Gut microbiome patterns provide clues to brain damage in extremely premature infants

Stem-like T cells within certain lymph nodes could be natural cancer fighters, study shows

CAR T cells expressing a natural RNA can activate the body’s own T cells against solid tumors

New computational approach may predict how individuals are likely to respond to vaccines

Cryogenic storage of biological specimens

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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