Cell Biology

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Intestinal grafts grown using stem cells could lead to personalized transplants for children

Pioneering scientists at the Francis Crick Institute, Great Ormond Street Hospital and UCL Great Ormond Street Institute of Child Health have grown human intestinal grafts using stem cells from patient tissue that could one day lead to personalized transplants for children with intestinal failure, according to a study published in Nature Medicine today (Monday 7th September).

10 Sep 2020

Fungi can develop drug resistance without genetic changes

The management of fungal infections in plants and humans could be transformed by a breakthrough in understanding how fungi develop resistance to drugs.

9 Sep 2020

Allergic immune response against bacteria is not pathological but protective

Allergy is one of the most common diseases in Europe, it is estimated that more than 150 million Europeans suffer from recurring allergies and by 2025 this could have increased to half of the entire European population.

9 Sep 2020

Common diabetes drug controls aspects of inflammation in mice

The diabetes drug metformin--derived from a lilac plant that's been used medicinally for more than a thousand years--has been prescribed to hundreds of millions of people worldwide as the frontline treatment for type 2 diabetes.

9 Sep 2020

Scientists shed new light on gene regulatory pathways activated by stress hormone

Scientists have long known that chronic stress experienced early in life, or even chronic prenatal exposure to maternal stress hormones in the womb, can shorten lifespan and contribute to age-related chronic diseases like arthritis, asthma, cancer, cardiovascular disease, diabetes and even mental illness later in life -- long after the source of stress has been removed.

9 Sep 2020

Computer model can replicate the unique firing-rate dependent behavior of Purkinje neurons

Research conducted by the Computational Neuroscience Unit at the Okinawa Institute of Science and Technology Graduate University has shown for the first time that a computer model can replicate and explain a unique property displayed by a crucial brain cell.

8 Sep 2020

New findings change the understanding of cholesterol’s effects on cellular membranes

For more than a decade, scientists have accepted that cholesterol - a key component of cell membranes - did not uniformly affect membranes of different types.

8 Sep 2020

Acne drug could be a potential treatment for dilated cardiomyopathy

Dilated cardiomyopathy (DCM) is a leading cause of heart failure, affecting 1 in 250 people. The disease is characterised by an increase in size of the left ventricle of the heart.

8 Sep 2020

Lack of oxygen can trigger tumor metastases

Metastases are formed by cancer cells that break away from the primary tumor. A research group at the University of Basel has now identified lack of oxygen as the trigger for this process.

8 Sep 2020

Moving towards a new age of personalized, cell-based interceptive medicine for Europe

Hundreds of innovators, research pioneers, clinicians, industry leaders and policy makers from all around Europe are united by a vision of how to revolutionize healthcare.

7 Sep 2020

Fly brain structure governed by lineage-dependent repulsion mechanism between neurons

The brain's structure has columnar features, which are hypothesized to arise from nerve cells (neurons) stemming from the same parent cell, initially forming radial units. How exactly this process unfolds at the molecular level remains unexplained, however.

5 Sep 2020

Maternal dietary imbalance triggers overeating in mice offspring

Pregnant mice fed a diet high in omega-6 fats and low in omega-3 fats produce offspring that go on to exhibit "hedonic"--pleasurable but excessive--levels of consumption of hyper-caloric diets, according to researchers at Hiroshima University.

5 Sep 2020

Activation of fatty acid receptor causes masculinization of Japanese rice fish

A research collaboration based at Kumamoto University (Japan) has found that activation of PPARα, a fatty acid receptor that detects fatty acids in cells and regulates physiological functions, causes masculinization of Japanese rice fish (medaka).

5 Sep 2020

CRISPR-based system suppresses genes related to AAV antibody production

Gene therapy generally relies on viruses, such as adeno-associated virus (AAV), to deliver genes into a cell. In the case of CRISPR-based gene therapies, molecular scissors can then snip out a defective gene, add in a missing sequence or enact a temporary change in its expression, but the body's immune response to AAV can thwart the whole endeavor.

4 Sep 2020

Research provides a map of coronavirus entry factors across the human body

An infection with the coronavirus SARS-CoV-2 can affect multiple organs. With this in mind, researchers of the German Center for Neurodegenerative Diseases and Cornell University in the US have investigated cellular factors that could be significant for an infection.

3 Sep 2020

Study: Antibiotics have prolonged effects on breast milk microbiota in mothers of preterm infants

A team led by researchers at the University of Toronto and The Hospital for Sick Children has found that mothers of preterm babies have highly individual breast milk microbiomes, and that even short courses of antibiotics have prolonged effects on the diversity and abundance of microbes in their milk.

3 Sep 2020

Cell Biology

Intestinal grafts grown using stem cells could lead to personalized transplants for children

Fungi can develop drug resistance without genetic changes

Allergic immune response against bacteria is not pathological but protective

Common diabetes drug controls aspects of inflammation in mice

Scientists shed new light on gene regulatory pathways activated by stress hormone

Computer model can replicate the unique firing-rate dependent behavior of Purkinje neurons

New findings change the understanding of cholesterol’s effects on cellular membranes

Acne drug could be a potential treatment for dilated cardiomyopathy

Lack of oxygen can trigger tumor metastases

Moving towards a new age of personalized, cell-based interceptive medicine for Europe

Fly brain structure governed by lineage-dependent repulsion mechanism between neurons

Maternal dietary imbalance triggers overeating in mice offspring

Activation of fatty acid receptor causes masculinization of Japanese rice fish

CRISPR-based system suppresses genes related to AAV antibody production

Research provides a map of coronavirus entry factors across the human body

Study: Antibiotics have prolonged effects on breast milk microbiota in mothers of preterm infants

Two MDC scientists win ERC Starting Grants for pioneering research

Study identifies subtypes and developmental process of novel immune T cells

Study identifies important regulator of neuron function and survival

Researchers investigate persistence of reproductive cells despite damage from jumping genes

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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