Cell Biology

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Lab-created heart valves implanted in young lambs can grow with the animal

A groundbreaking new study led by University of Minnesota Twin Cities researchers from both the College of Science and Engineering and the Medical School shows for the first time that lab-created heart valves implanted in young lambs for a year were capable of growth within the recipient.

17 Mar 2021

New method for growing embryos outside the womb

To observe how a tiny ball of identical cells on its way to becoming a mammalian embryo first attaches to an awaiting uterine wall and then develops into nervous system, heart, stomach and limbs: This has been a highly-sought grail in the field of embryonic development for nearly 100 years.

17 Mar 2021

Researchers find a better way to identify cells and understand the mechanisms of diseases

In researching the causes and potential treatments for degenerative conditions such as Alzheimer's or Parkinson's disease, neuroscientists frequently struggle to accurately identify cells needed to understand brain activity that gives rise to behavior changes such as declining memory or impaired balance and tremors.

17 Mar 2021

Beneficial effects of gene therapy can be seen in SCID-X1 patients decades after treatment

An international collaboration between Great Ormond Street Hospital, the UCL GOS Institute for Child Health and Harvard Medical School has shown that the beneficial effects of gene therapy can be seen decades after the transplanted blood stem cells has been cleared by the body.

17 Mar 2021

Researchers explore potential role of TARM1 protein in pathogenesis of rheumatoid arthritis

TARM1 is a receptor protein whose role in the functioning of the immune system is unknown. In a new study, scientists from Japan have explored the potential role of TARM1 in the pathogenesis of rheumatoid arthritis by analyzing mouse models.

17 Mar 2021

Insights into elusive protein complex can help find novel treatments for chromosomal disorders

The cells in our body are constantly fighting off the threat of cancer by repairing damaged DNA. In a new study, scientists from Tokyo University of Science investigate the structure of an elusive protein complex that plays a key role in the activation of the "Fanconi anemia pathway" involved in DNA repair, and report on the factors governing its stability.

17 Mar 2021

Study investigates how neurons construct synapses of different strengths

Job descriptions for the thousands of types of neurons in the brain typically include a common function: release chemicals called neurotransmitters to communicate across circuit connections called synapses.

17 Mar 2021

Amino acids signaling controls whole-body glucose homeostasis, study shows

Amino acids are a major nutrient type for humans and are used as building blocks and a source of energy for cells.

16 Mar 2021

Heinz Maier-Leibnitz Prizes for 2021 go to four female and six male researchers

Four female and six male researchers are to receive the Heinz Maier-Leibnitz Prize this year, the top award for early career investigators in Germany.

16 Mar 2021

Study identifies how environmental information is transmitted by non-DNA molecules in the sperm

It has long been understood that a parent's DNA is the principal determinant of health and disease in offspring.

16 Mar 2021

Scientists explore the negative effects of prenatal stress on offspring mental health

The link between psychological stress and physical health problems generally relates to a stress-induced immune response gone wild, with inflammation then causing damage to other systems in the body. It's a predictable cascade - except in pregnancy, research suggests.

16 Mar 2021

Allogeneic adipose-derived stem cells can mitigate TBI-induced acute radiation syndrome

Nuclear power offers an efficient, reliable way to provide energy to large populations - as long as all goes well. Accidents involving nuclear reactors such as those that took place in 1986 at Chernobyl and at Fukushima Daiichi after the March 2011 tsunami raise major concerns about what happens if the worst occurs and large numbers of people are simultaneously exposed to high levels of radiation.

16 Mar 2021

Ketogenesis has a protective effect on mitochondria, finds study

Ketone bodies are generally an alternative energy source during starvation, but in newborns, ketogenesis is active regardless of nutritional status. In a recent study from Kumamoto University (Japan), researchers analyzed the effects of ketogenesis in mice and found that it has a protective effect on cells by maintaining the function of mitochondria.

16 Mar 2021

Chromatin-regulating enzyme found to be a key driver of common lung cancer

A chromatin-regulating enzyme has been shown by in-depth interdisciplinary investigations to be a key driver of a common type of lung cancer. Drugs that target the enzyme could improve treatment and survival rates for this particular cancer.

15 Mar 2021

Researchers identify epigenetic mechanism responsible for lifelong stress susceptibility

An epigenetic modification that occurs in a major cell type in the brain's reward circuitry controls how stress early in life increases susceptibility to additional stress in adulthood, researchers at the Icahn School of Medicine at Mount Sinai have learned.

15 Mar 2021

MGH researchers uncover new clues about X chromosome inactivation

Researchers at Massachusetts General Hospital have uncovered new clues that add to the growing understanding of how female mammals, including humans, "silence" one X chromosome.

15 Mar 2021

Novel computer-guided design tool helps increase the efficiency of cell conversions

There is a great need to generate various types of cells for use in new therapies to replace tissues that are lost due to disease or injuries, or for studies outside the human body to improve our understanding of how organs and tissues function in health and disease.

13 Mar 2021

Cell Biology

Lab-created heart valves implanted in young lambs can grow with the animal

New method for growing embryos outside the womb

Researchers find a better way to identify cells and understand the mechanisms of diseases

Beneficial effects of gene therapy can be seen in SCID-X1 patients decades after treatment

Researchers explore potential role of TARM1 protein in pathogenesis of rheumatoid arthritis

Insights into elusive protein complex can help find novel treatments for chromosomal disorders

Study investigates how neurons construct synapses of different strengths

Amino acids signaling controls whole-body glucose homeostasis, study shows

Heinz Maier-Leibnitz Prizes for 2021 go to four female and six male researchers

Study identifies how environmental information is transmitted by non-DNA molecules in the sperm

Scientists explore the negative effects of prenatal stress on offspring mental health

Allogeneic adipose-derived stem cells can mitigate TBI-induced acute radiation syndrome

Ketogenesis has a protective effect on mitochondria, finds study

Chromatin-regulating enzyme found to be a key driver of common lung cancer

Researchers identify epigenetic mechanism responsible for lifelong stress susceptibility

MGH researchers uncover new clues about X chromosome inactivation

Novel computer-guided design tool helps increase the efficiency of cell conversions

Random cellular changes play vital role in longevity beyond genetics and environment

Neutralizing antibodies induced by COVID-19 vaccines less effective against new variants

New book explains concept and knowledge maps about biochemical compounds

Evolving spectrophotometry for modern biopharma workflows

Scaling B-cell cloning workflows for antibody development

Fluidics in Modern Healthcare & Medical Device Innovation

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