Cell Biology

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Researchers identify enzyme essential for intestinal epithelial differentiation

The intestinal epithelium is the inner layer of the intestinal wall, which separates host tissue from the intestinal microbiota.

8 Jun 2020

Study offers a deeper understanding of T cell immunity in the elderly

A study by Monash Biomedicine Discovery Institute (BDI) expands the understanding of the molecular pathways that control T cell function and survival and how it relates to declining T cell immunity in the elderly.

5 Jun 2020

New images of LSD1 enzyme in action shed light on gene regulation

New images of an enzyme in action as it interacts with the chromosome could provide important insight into how cells--including cancer cells--regulate their genes.

5 Jun 2020

Exploring the molecular landscape of the aortic niche and beyond

Researchers from the group of Catherine Robin at the Hubrecht Institute characterized the molecular landscape of the aorta that supports the generation of the first Hematopoietic Stem Cells (HSCs) in the embryo.

4 Jun 2020

Scientists provide clarity into how cells remember their identity

Cancer is often the result of DNA mutations or problems with how cells divide, which can lead to cells "forgetting" what type of cell they are or how to function properly.

4 Jun 2020

Researchers discover novel gene involved in DNA damage repair and male fertility

A research group from the Institute of Molecular Embryology and Genetics at Kumamoto University, Japan has discovered that the gene C19ORF57 plays a critical role in meiosis.

4 Jun 2020

Study reveals biochemical alterations in patients with Lesch-Nyhan disease

An international study by the Institute of Neuroscience of the UAB, Emory University and Hospital Universitario La Paz, published in the PNAS journal, shows that patients suffering from Lesch-Nyhan, a rare neurological disease, present biochemical alterations in skin cells (fibroblasts), urine and cerebrospinal fluid.

4 Jun 2020

Hairy human skin grown from pluripotent stem cells

Building on years of groundbreaking discoveries in stem cell research, scientists from Indiana University School of Medicine and Harvard Medical School have determined how to grow hairy skin using human stem cells--developing one of the most complex skin models in the world.

4 Jun 2020

Researchers decipher deadly bacterial infection in pigs

The Clostridium perfringens bacterium is part of the large Clostridium genus which can cause various fatal illnesses in animals and humans.

4 Jun 2020

Small protein has a large impact on bacterial gene regulation

Meningococci are bacteria that can cause life-threatening meningitis and sepsis. These pathogens use a small protein with a large impact: The RNA-binding protein ProQ is involved in the activation of more than 250 bacterial genes.

4 Jun 2020

Diet and gut microbiome affect outcomes of chemotherapy

What we eat can affect the outcome of chemotherapy – and likely many other medical treatments – because of ripple effects that begin in our gut, new research from the University of Virginia suggests.

4 Jun 2020

Hesperos’ immune system-on-a-chip emulates immune reactions for tissue damage and acute inflammation

Hesperos Inc., pioneers of the Human-on-a-Chip in vitro system, today announced the publication of a new peer-reviewed publication that describes how the company’s technology can be used to investigate immune responses following treatment with biological therapeutics for multi-organ systemic diseases, including cancer, infectious diseases and inflammatory disorders.

4 Jun 2020

Using advanced microscopy techniques to see single molecules of telomerase in living cells

Canadian scientists have achieved a first in the study of telomerase, an essential enzyme implicated in aging and cancer.

3 Jun 2020

Scientists uncover why developing nerve cells take a wrong turn

A group of scientists from CECAD, the Cluster of Excellence 'Cellular Stress Responses in Aging-Associated Diseases,' have found a mechanism by which neurodevelopmental diseases concerning neurons can be explained: The loss of a certain enzyme, UBE2K, impeded the differentiation of stem cells by silencing the expression of genes important for neuronal differentiation and, therefore, the development and generation of neurons.

3 Jun 2020