Cell Biology

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Estrogen uses certain cell type as 'mediator' for beneficial effects on the bone, research shows

The female sex hormone estrogen plays an important role in the structural stability of bones. To date, however, it had been unclear exactly which cells were involved in the hormone's protective function in preventing changes in bone density.

28 Jul 2017

Scientists uncover link between backup pathogen-fighting system and mutations in Crohn's patients

Genes that regulate a cellular recycling system called autophagy are commonly mutated in Crohn's disease patients, though the link between biological housekeeping and inflammatory bowel disease remained a mystery. Now, researchers at UT Southwestern Medical Center have uncovered an intriguing clue.

28 Jul 2017

New approach may improve translation of immunological research findings

Mouse models have advanced our understanding of immune function and disease in many ways but they have failed to account for the natural diversity in human immune responses.

27 Jul 2017

Research shows key role of diffusion dynamics in stem cell differentiation and tissue development

Gradients of molecular signaling factors play an essential role in numerous events in embryonic development, from patterning limb and organ formation to the intricate shaping of the brain and neuroanatomical architecture.

27 Jul 2017

US scientists make advances in modifying human embryos

American Scientists have managed to edit and improve the DNA of human embryos in an effort to correct the gene defects that cause inherited diseases.

27 Jul 2017

Scientists uncover mechanism that keeps cells in the right places

Scientists have uncovered how cells are kept in the right place as the body develops, which may shed light on what causes invasive cancer cells to migrate.

26 Jul 2017

Stem cells in the brain found to regulate aging

Scientists at Albert Einstein College of Medicine have found that stem cells in the brain's hypothalamus govern how fast aging occurs in the body.

26 Jul 2017

Scientists reveal communication system between knee joint and developing bones in mice

Scientists from the Memorial Sloan Kettering Cancer Center, US, have revealed a communication system between the knee joint and developing bones in mice, which controls bone growth during early development and after injury.

25 Jul 2017

Princeton scientists test cell-culture system to aid study of HBV infections

Scientists from Princeton University's Department of Molecular Biology have successfully tested a cell-culture system that will allow researchers to perform laboratory-based studies of long-term hepatitis B virus (HBV) infections

25 Jul 2017

Low vitamin D may affect recovery of injured corneas

Injury or disease in combination with too little vitamin D can be bad for the window to your eyes. The three-layer, transparent cornea at the front of the eyes focuses the light coming in. But its prominent position also puts it at risk for injury from an errant mascara wand or over-prodding finger or a car accident.

24 Jul 2017

LMU neurobiologists present new theory for origin of grid cells

Ludwig-Maximilians-Universitaet in Munich neurobiologists present a new theory for the origin of the grid cells required for spatial orientation in the mammalian brain, which assigns a vital role to the timing of trains of signals they receive from neurons called place cells.

21 Jul 2017

Researchers show how hematopoietic stem cells detect and react to infections

Researchers at the University of Zurich have shown for the first time that hematopoietic stem cells detect infectious agents themselves and begin to divide - that is, without signals from growth factors.

20 Jul 2017

Lunatic fringe gene plays role in regulating fate of neural stem cells

The discovery that the brain can generate new cells - about 700 new neurons each day - has triggered investigations to uncover how this process is regulated.

19 Jul 2017

Scientists discover how CD44s molecule gives brain cancer cells a survival advantage

Understanding the mechanisms that give cancer cells the ability to survive and grow opens the possibility of developing improved treatments to control or cure the disease.

19 Jul 2017

Two cell types partner to protect pancreatic tumors from immune attack

Two cell types work together to protect pancreatic tumors from destruction by the immune system. But, blocking this partnership may restore the system's ability to attack these same tumor cells.

19 Jul 2017

Scientists manage to permeate living cells with small antibodies

Scientists at the Technische Universität Darmstadt, Ludwig Maximilians University Munich and the Leibniz Institute for Molecular Pharmacology have managed to introduce tiny antibodies into living cells. The researchers now report on the synthesis and applications for these nanobodies in "Nature Chemistry".

19 Jul 2017

Study shows how cells feel their way through the surroundings

Cells push out tiny feelers to probe their physical surroundings, but how much can these tiny sensors really discover? A new study led by Princeton University researchers and colleagues finds that the typical cell's environment is highly varied in the stiffness or flexibility of the surrounding tissue, and that to gain a meaningful amount of information about its surroundings, the cell must move around and change shape.

18 Jul 2017

Developing software for cell and gene therapy supply chain tracking

The first thing is, to always remember that we're dealing with a living drug, cells, which are very sensitive to environmental conditions, such as temperature and humidity etc. All of those things can impact on the viability of the drug and its effectiveness.

18 Jul 2017

UW-Madison researchers jump major hurdle on path toward wider use of stem cells

Since highly versatile human stem cells were discovered at the University of Wisconsin-Madison nearly 20 years ago, their path to the market and clinic has been slowed by a range of complications.

14 Jul 2017

Researchers get closer to finding out how cells and their nucleus grow at constant ratio

Over a century since scientists first observed that cells and their nucleus grow at a constant ratio to each other, we are now closer to finding out how.

11 Jul 2017